Involvement of PI3K/Akt Signaling Pathway and Its Downstream Intracellular Targets in the Antidepressant-Like Effect of Creatine

The modulation of NMDA receptors and l-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test

(2015) Mauricio P. Cunha et al.   AMINO ACIDS

Both Creatine and Its Product Phosphocreatine Reduce Oxidative Stress and Afford Neuroprotection in an In Vitro Parkinson’s Model

(2014) Mauricio Peña Cunha et al.   ASN Neuro

Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons

(2014) Sung Woo Park et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

MAPK signaling correlates with the antidepressant effects of ketamine

(2014) Gislaine Z. Réus et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Involvement of PKA, PKC, CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice

(2014) Mauricio P. Cunha et al.   Pharmacological Reports

Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice

(2013) Mauricio P. Cunha et al.   BRAIN RESEARCH BULLETIN

Akt2 Deficiency is Associated with Anxiety and Depressive Behavior in Mice

(2013) Christina Leibrock et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Antidepressant-like effect of ascorbic acid is associated with the modulation of mammalian target of rapamycin pathway

(2013) Morgana Moretti et al.   JOURNAL OF PSYCHIATRIC RESEARCH

GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine

(2013) Rong-Jian Liu et al.   NEUROPSYCHOPHARMACOLOGY

Protective effect of creatine against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells: Involvement of intracellular signaling pathways

(2013) M.P. Cunha et al.   NEUROSCIENCE

The activation of α1-adrenoceptors is implicated in the antidepressant-like effect of creatine in the tail suspension test

(2013) Mauricio P. Cunha et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Nrf2 participates in depressive disorders through an anti-inflammatory mechanism

(2013) María Dolores Martín-de-Saavedra et al.   PSYCHONEUROENDOCRINOLOGY

A Randomized, Double-Blind Placebo-Controlled Trial of Oral Creatine Monohydrate Augmentation for Enhanced Response to a Selective Serotonin Reuptake Inhibitor in Women With Major Depressive Disorder

(2012) In Kyoon Lyoo et al.   AMERICAN JOURNAL OF PSYCHIATRY

Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide–cGMP and PI3K/mTOR pathways

(2012) Luis E.B. Bettio et al.   BEHAVIOURAL BRAIN RESEARCH

Fluoxetine Upregulates Phosphorylated-AKT and Phosphorylated-ERK1/2 Proteins in Neural Stem Cells: Evidence for a Crosstalk between AKT and ERK1/2 Pathways

(2012) Wen Huang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Antidepressant-like effect of creatine in mice involves dopaminergic activation

(2012) Mauricio P Cunha et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Creatine supplementation with specific view to exercise/sports performance: an update

(2012) Robert Cooper et al.   Journal of the International Society of Sports Nutrition

Activation of protein kinase B/Akt by alpha1-adrenoceptors in the human prostate

(2012) Frank Strittmatter et al.   LIFE SCIENCES

Phosphocreatine Interacts with Phospholipids, Affects Membrane Properties and Exerts Membrane-Protective Effects

(2012) Malgorzata Tokarska-Schlattner et al.   PLoS One

Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: A 31-phosphorus magnetic resonance spectroscopy study

(2011) Douglas G. Kondo et al.   JOURNAL OF AFFECTIVE DISORDERS

Involvement of PI3K, GSK-3β and PPARγ in the antidepressant-like effect of folic acid in the forced swimming test in mice

(2011) Josiane Budni et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Signaling pathways underlying the rapid antidepressant actions of ketamine

(2011) Ronald S. Duman et al.   NEUROPHARMACOLOGY

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats

(2009) Yueh-Hua Tai et al.   ANESTHESIOLOGY

Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

(2009) Tae Kyeong Shin et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Fluvoxamine and sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate induces the Ser473-phosphorylation of Akt-1 in PC12 cells

(2009) Miho Nakano et al.   LIFE SCIENCES

Chronic Creatine Supplementation Alters Depression-like Behavior in Rodents in a Sex-Dependent Manner

(2009) Patricia J Allen et al.   NEUROPSYCHOPHARMACOLOGY

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Akt/GSK3 Signaling in the Action of Psychotropic Drugs

(2008) Jean-Martin Beaulieu et al.   Annual Review of Pharmacology and Toxicology

AKT Signaling within the Ventral Tegmental Area Regulates Cellular and Behavioral Responses to Stressful Stimuli

(2008) Vaishnav Krishnan et al.   BIOLOGICAL PSYCHIATRY

Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice

(2008) Angelo O. Rosa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY