Deciphering the Differential Effective and Toxic Responses of Bupleuri Radix following the Induction of Chronic Unpredictable Mild Stress and in Healthy Rats Based on Serum Metabolic Profiles

An astroglial basis of major depressive disorder? An overview

(2017) Qian Wang et al.   GLIA

Ceramides and depression: A systematic review

(2017) Adam Dinoff et al.   JOURNAL OF AFFECTIVE DISORDERS

Validated UPLC-MS/MS method for simultaneous quantification of eight saikosaponins in rat plasma: Application to a comparative pharmacokinetic study in depression rats after oral administration of extracts of raw and vinegar-baked Bupleuri Radix

(2017) Tianli Lei et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study

(2017) Marie Hennebelle et al.   PSYCHIATRY RESEARCH

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation

(2017) Jingzhuo Tian et al.   Scientific Reports

Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology

(2017) Fude Yang et al.   Biomed Research International

Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder

(2017) Hidehiro Umehara et al.   Scientific Reports

3-Ketosphinganine provokes the accumulation of dihydroshingolipids and induces autophagy in cancer cells

(2016) Yadira F. Ordóñez et al.   Molecular BioSystems

Metabolism of glycerophospholipid, bile acid and retinol is correlated with the early outcomes of autoimmune hepatitis

(2016) Chao Zhou et al.   Molecular BioSystems

A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications

(2016) Bochuan Yuan et al.   PHARMACEUTICAL BIOLOGY

Intermediates of Metabolism: From Bystanders to Signalling Molecules

(2016) Robert Haas et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chronic unpredictive mild stress leads to altered hepatic metabolic profile and gene expression

(2016) Hong-mei Jia et al.   Scientific Reports

Brain membrane lipids in major depression and anxiety disorders

(2015) Christian P. Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Plasma-metabolite-biomarkers for the therapeutic response in depressed patients by the traditional Chinese medicine formula Xiaoyaosan: A 1H NMR-based metabolomics approach

(2015) Cai-Chun Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

A qualitative, and quantitative determination and pharmacokinetic study of four polyacetylenes from Radix Bupleuri by UPLC-PDA–MS

(2015) Jiali Liu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography–Mass Spectrometry

(2015) Xinyu Liu et al.   JOURNAL OF PROTEOME RESEARCH

Sphingolipids in Major Depression

(2015) Peter L. Jernigan et al.   NEUROSIGNALS

Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants

(2015) Alan Pehrson et al.   Drug Design Development and Therapy

Effects of oxidative stress on fatty acid- and one-carbon-metabolism in psychiatric and cardiovascular disease comorbidity

(2014) J. Assies et al.   ACTA PSYCHIATRICA SCANDINAVICA

UPLC–MSE application in disease biomarker discovery: The discoveries in proteomics to metabolomics

(2014) Ying-Yong Zhao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Metabolomics and the Diagnosis of Human Diseases -A Guide to the Markers and Pathophysiological Pathways Affected

(2014) S. Medina et al.   CURRENT MEDICINAL CHEMISTRY

Mitochondrial protein acetylation regulates metabolism

(2014) Kristin A. Anderson et al.   Essays in Biochemistry

Elevated Plasma Ceramides in Depression

(2014) Patricia Gracia-Garcia et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Alterations of Amino Acid Level in Depressed Rat Brain

(2014) Pei Yang et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Liquid chromatography–mass spectrometry in metabolomics research: Mass analyzers in ultra high pressure liquid chromatography coupling

(2013) Sara Forcisi et al.   JOURNAL OF CHROMATOGRAPHY A

Global and Targeted Metabolomics Reveal That Bupleurotoxin, a Toxic Type of Polyacetylene, Induces Cerebral Lesion by Inhibiting GABA Receptor in Mice

(2013) Zhongxiao Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Hippocampus and serum metabolomic studies to explore the regulation of Chaihu-Shu-Gan-San on metabolic network disturbances of rats exposed to chronic variable stress

(2013) Zhi-heng Su et al.   Molecular BioSystems

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

1H-NMR-Based Metabonomic Studies on the Anti-Depressant Effect of Genipin in the Chronic Unpredictable Mild Stress Rat Model

(2013) Jun-Sheng Tian et al.   PLoS One

Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

(2013) April D. Lake et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats

(2013) Makoto Yamazaki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bridging the traditional chinese medicine pattern classification and biomedical disease diagnosis with systems biology

(2012) Ai-ping Lu et al.   Chinese Journal of Integrative Medicine

Beneficial Effect of the Polysaccharides from Bupleurum smithii var. parvifolium on “Two-Hit” Acute Lung Injury in Rats

(2012) Xiao-Qin Cheng et al.   INFLAMMATION

Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway

(2012) Chun-Ni Lu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Deciphering the Differential Toxic Responses of Radix aconiti lateralis praeparata in Healthy and Hydrocortisone-Pretreated Rats Based on Serum Metabolic Profiles

(2012) Yong Tan et al.   JOURNAL OF PROTEOME RESEARCH

Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T1H-MRS

(2012) Jimin Ren et al.   MAGNETIC RESONANCE IN MEDICINE

Liquid chromatography–mass spectrometry based global metabolite profiling: A review

(2011) Georgios A. Theodoridis et al.   ANALYTICA CHIMICA ACTA

The hydrophobic dipeptide Leu–Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF

(2011) Yoko Furukawa-Hibi et al.   BEHAVIOURAL BRAIN RESEARCH

Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-αin High-Fat-Diet-Induced Obese Rats

(2011) Thing-Fong Tzeng et al.   Evidence-based Complementary and Alternative Medicine

Antidepressant-like effects of the fractions of Xiaoyaosan on rat model of chronic unpredictable mild stress

(2011) Yuzhi Zhou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Depression and Hypothalamic-Pituitary-Adrenal Activation: A Quantitative Summary of Four Decades of Research

(2011) Cinnamon Stetler et al.   PSYCHOSOMATIC MEDICINE

Acetyl-l-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy

(2011) Mariano Malaguarnera et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications

(2010) Johannes Kornhuber et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Plasma and Erythrocyte Fatty Acid Patterns in Patients with Recurrent Depression: A Matched Case-Control Study

(2010) Johanna Assies et al.   PLoS One

Multiple aberrations in shared inflammatory and oxidative & nitrosative stress (IO&NS) pathways explain the co-association of depression and cardiovascular disorder (CVD), and the increased risk for CVD and due mortality in depressed patients

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Lysophosphatidylcholine Enhances Oxidative Stress Via the 5-Lipoxygenase Pathway in Rat Aorta During Aging

(2009) Yani Zou et al.   REJUVENATION RESEARCH

Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress

(2008) Yan Ni et al.   FEBS LETTERS

Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model

(2007) Johannes Kornhuber et al.   JOURNAL OF MEDICINAL CHEMISTRY