Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2

Syncytins expressed in human placental trophoblast

(2021) R. Michael Roberts et al.   PLACENTA

Strategies for delivering therapeutics across the blood–brain barrier

(2021) Georg C. Terstappen et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis of omega-3 fatty acid transport across the blood–brain barrier

(2021) Rosemary J. Cater et al.   NATURE

Structure and mechanism of blood–brain-barrier lipid transporter MFSD2A

(2021) Chase A. P. Wood et al.   NATURE

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis

(2020) Bing Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

(2020) Yasunori Watanabe et al.   Nature Communications

Biallelic MFSD2A variants associated with congenital microcephaly, developmental delay, and recognizable neuroimaging features

(2020) Marcello Scala et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Physiological blood–brain transport is impaired with age by a shift in transcytosis

(2020) Andrew C. Yang et al.   NATURE

Binding mechanisms of therapeutic antibodies to human CD20

(2020) Anand Kumar et al.   SCIENCE

Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

(2020) Ali Punjani et al.   NATURE METHODS

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Valery L Feigin et al.   LANCET NEUROLOGY

Suppression of transcytosis regulates zebrafish blood-brain barrier function

(2019) Natasha M O'Brown et al.   eLife

DALI and the persistence of protein shape

(2019) Liisa Holm   PROTEIN SCIENCE

X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications

(2019) Katinka Ruigrok et al.   JOURNAL OF MOLECULAR BIOLOGY

Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines

(2018) Felix A. Rey et al.   CELL

CASTp 3.0: computed atlas of surface topography of proteins

(2018) Wei Tian et al.   NUCLEIC ACIDS RESEARCH

MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells

(2018) Naoki Kobayashi et al.   Scientific Reports

Automated map sharpening by maximization of detail and connectivity

(2018) Thomas C. Terwilliger et al.   Acta Crystallographica Section D-Structural Biology

Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination

(2018) Tamar Harel et al.   NEUROGENETICS

Structural basis of coreceptor recognition by HIV-1 envelope spike

(2018) Md Munan Shaik et al.   NATURE

Consensus designs and thermal stability determinants of a human glutamate transporter

(2018) Erica Cirri et al.   eLife

Structure and allosteric inhibition of excitatory amino acid transporter 1

(2017) Juan C. Canul-Tec et al.   NATURE

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

(2017) Thiet M. Vu et al.   NATURE

Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike

(2017) Gabriel Ozorowski et al.   NATURE

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation

(2017) Brian Wai Chow et al.   NEURON

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development

(2016) Bernice H. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into the Transport Mechanism of the Human Sodium-dependent Lysophosphatidylcholine Transporter MFSD2A

(2016) Debra Q. Y. Quek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

(2016) Esben M. Quistgaard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mfsd2a-based pharmacological strategies for drug delivery across the blood–brain barrier

(2016) Jing-Zhang Wang et al.   PHARMACOLOGICAL RESEARCH

Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2

(2016) Lina Cui et al.   Cell Adhesion & Migration

Structural Biology of the Major Facilitator Superfamily Transporters

(2015) Nieng Yan   Annual Review of Biophysics

A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome

(2015) Vafa Alakbarzade et al.   NATURE GENETICS

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

(2015) Alicia Guemez-Gamboa et al.   NATURE GENETICS

JPred4: a protein secondary structure prediction server

(2015) Alexey Drozdetskiy et al.   NUCLEIC ACIDS RESEARCH

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation

(2013) C. Lavialle et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pathogens and the placental fortress

(2011) Jennifer R Robbins et al.   CURRENT OPINION IN MICROBIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

One-step split GFP staining for sensitive protein detection and localization in mammalian cells

(2010) Lara Kaddoum et al.   BIOTECHNIQUES

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Functional Characterization of the Human Placental Fusogenic Membrane Protein Syncytin 21

(2008) Chie-Pein Chen et al.   BIOLOGY OF REPRODUCTION

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2

(2008) C. Esnault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA