Structural basis of omega-3 fatty acid transport across the blood–brain barrier

Biallelic MFSD2A variants associated with congenital microcephaly, developmental delay, and recognizable neuroimaging features

(2020) Marcello Scala et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Scalable molecular dynamics on CPU and GPU architectures with NAMD

(2020) James C. Phillips et al.   JOURNAL OF CHEMICAL PHYSICS

Cryo-electron microscopy analysis of small membrane proteins

(2020) Rie Nygaard et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Multidrug Transporter MdfA Deviates from the Canonical Model of Alternating Access of MFS Transporters

(2020) Eliane H. Yardeni et al.   JOURNAL OF MOLECULAR BIOLOGY

Novel neuroclinical findings of autosomal recessive primary microcephaly 15 in a consanguineous Iranian family

(2020) Ehsan Razmara et al.   European Journal of Medical Genetics

A 10-year meta-analysis of membrane protein structural biology: Detergents, membrane mimetics, and structure determination techniques

(2020) Brendon C. Choy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Namdinator – automatic molecular dynamics flexible fitting of structural models into cryo-EM and crystallography experimental maps

(2019) Rune Thomas Kidmose et al.   IUCrJ

Imidazole Derivatives Improve Charge Reduction and Stabilization for Native Mass Spectrometry

(2019) Julia A. Townsend et al.   ANALYTICAL CHEMISTRY

Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction

(2019) Ekaterina S. Lobanova et al.   JOURNAL OF NEUROSCIENCE

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

(2019) Jonathan Kim et al.   NATURE

Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs

(2019) Tristan Bepler et al.   NATURE METHODS

Current Developments in Coot for Macromolecular Model Building of Electron Cryo‐microscopy and Crystallographic Data

(2019) Ana Casañal et al.   PROTEIN SCIENCE

How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties

(2018) Asghar M. Razavi et al.   BMC BIOLOGY

Routine determination of ice thickness for cryo-EM grids

(2018) William J. Rice et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cryo-EM in drug discovery: achievements, limitations and prospects

(2018) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin

(2018) Giulia Morra et al.   STRUCTURE

MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells

(2018) Naoki Kobayashi et al.   Scientific Reports

CCP4i2: the new graphical user interface to the CCP4 program suite

(2018) Liz Potterton et al.   Acta Crystallographica Section D-Structural Biology

High resolution single particle cryo-electron microscopy using beam-image shift

(2018) Anchi Cheng et al.   JOURNAL OF STRUCTURAL BIOLOGY

Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination

(2018) Tamar Harel et al.   NEUROGENETICS

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

(2018) Byoung-Cheol Lee et al.   Nature Communications

The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain

(2018) Jia Pei Chan et al.   PLOS BIOLOGY

A dual substrate-accessing mechanism of a major facilitator superfamily protein facilitates lysophospholipid flipping across the cell membrane

(2018) Yibin Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

(2017) Thiet M. Vu et al.   NATURE

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

OpenMM 7: Rapid development of high performance algorithms for molecular dynamics

(2017) Peter Eastman et al.   PLoS Computational Biology

A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter

(2017) Asghar M. Razavi et al.   Scientific Reports

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development

(2016) Bernice H. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into the Transport Mechanism of the Human Sodium-dependent Lysophosphatidylcholine Transporter MFSD2A

(2016) Debra Q. Y. Quek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

(2016) Esben M. Quistgaard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs

(2016) Pawel K. Dominik et al.   STRUCTURE

Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles

(2015) Michael T. Marty et al.   ANALYTICAL CHEMISTRY

Structural Biology of the Major Facilitator Superfamily Transporters

(2015) Nieng Yan   Annual Review of Biophysics

Structure and mechanism of an active lipid-linked oligosaccharide flippase

(2015) Camilo Perez et al.   NATURE

A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome

(2015) Vafa Alakbarzade et al.   NATURE GENETICS

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

(2015) Alicia Guemez-Gamboa et al.   NATURE GENETICS

Structural Analysis of Bacterial ABC Transporter Inhibition by an Antibody Fragment

(2015) Shivani Ahuja et al.   STRUCTURE

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Structure-based mechanism for Na+/melibiose symport by MelB

(2014) Abdul S. Ethayathulla et al.   Nature Communications

Identification of slow molecular order parameters for Markov model construction

(2013) Guillermo Pérez-Hernández et al.   JOURNAL OF CHEMICAL PHYSICS

Simulations of Anionic Lipid Membranes: Development of Interaction-Specific Ion Parameters and Validation Using NMR Data

(2013) Richard M. Venable et al.   JOURNAL OF PHYSICAL CHEMISTRY B

T Cell Receptor-Like Recognition of Tumor In Vivo by Synthetic Antibody Fragment

(2012) Keith R. Miller et al.   PLoS One

MSMBuilder2: Modeling Conformational Dynamics on the Picosecond to Millisecond Scale

(2011) Kyle A. Beauchamp et al.   Journal of Chemical Theory and Computation

Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins

(2011) Shahir S Rizk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

3V: cavity, channel and cleft volume calculator and extractor

(2010) N. R. Voss et al.   NUCLEIC ACIDS RESEARCH

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

CHARMM-GUI Membrane Builder for Mixed Bilayers and Its Application to Yeast Membranes

(2009) Sunhwan Jo et al.   BIOPHYSICAL JOURNAL

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Macromolecular Modeling with Rosetta

(2008) Rhiju Das et al.   Annual Review of Biochemistry

CHAINSAW: a program for mutating pdb files used as templates in molecular replacement

(2008) Norman Stein   JOURNAL OF APPLIED CRYSTALLOGRAPHY

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE