Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination

Protease‐activated prodrugs: strategies, challenges, and future directions

(2020) Marcin Poreba   FEBS Journal

Bioanalytical method development and validation of a liquid chromatography-tandem mass spectrometry method for determination of β-lapachone in human plasma

(2020) William C. Putnam et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation

(2019) Hans‐Georg Lerchen et al.   CHEMISTRY-A EUROPEAN JOURNAL

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

(2019) Xiaoguang Li et al.   Nature Communications

The Neonatal Fc Receptor (FcRn): A Misnomer?

(2019) Michal Pyzik et al.   Frontiers in Immunology

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones

(2019) Eufrânio N. da Silva Júnior et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ethoxy mansonone G as an anticancer agent in estrogen receptor‐positive and endocrine‐resistant breast cancer

(2019) Piriya Chonsut et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody–Drug Conjugates with Phenol-Containing Payloads

(2018) Donglu Zhang et al.   BIOCONJUGATE CHEMISTRY

Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side

(2018) Rodrigo Prieto-Bermejo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IMGN779, a Novel CD33-Targeting Antibody–Drug Conjugate with DNA-Alkylating Activity, Exhibits Potent Antitumor Activity in Models of AML

(2018) Yelena Kovtun et al.   MOLECULAR CANCER THERAPEUTICS

Antibody drug conjugates (ADCs) charged with HDAC inhibitor for targeted epigenetic modulation

(2018) Elena Cini et al.   Chemical Science

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

(2018) Tiago Rodrigues et al.   Chemical Science

Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis

(2018) David E. Gerber et al.   BRITISH JOURNAL OF CANCER

Modulating ROS to overcome multidrug resistance in cancer

(2018) Qingbin Cui et al.   DRUG RESISTANCE UPDATES

Anticancer Activity of Natural Compounds from Plant and Marine Environment

(2018) Anna Lichota et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deamidation and isomerization liability analysis of 131 clinical-stage antibodies

(2018) Xiaojun Lu et al.   mAbs

Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents

(2018) Barbara Bernardim et al.   Nature Protocols

A Brief Introduction to Antibody–Drug Conjugates for Toxicologic Pathologists

(2018) Lars Mecklenburg   TOXICOLOGIC PATHOLOGY

Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents

(2017) Serdar Burmaoğlu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Intracellular trafficking of new anticancer therapeutics: antibody–drug conjugates

(2017) Muhammad Kalim et al.   Drug Design Development and Therapy

Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification

(2017) Trevor M. Penning   Toxicology Research

Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity

(2017) Anwar Rayan et al.   PLoS One

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors

(2016) Xiumei Huang et al.   CANCER CELL

Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects

(2016) Judy L. Bolton et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Considerations and challenges for patients with refractory and relapsed acute myeloid leukaemia

(2016) Jonathan Kell   LEUKEMIA RESEARCH

Counting on natural products for drug design

(2016) Tiago Rodrigues et al.   Nature Chemistry

Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2

(2016) Pushparathinam Gopinath et al.   Chemical Science

Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

(2016) Barbara Bernardim et al.   Nature Communications

Lysosome-oriented, dual-stage pH-responsive polymeric micelles for β-lapachone delivery

(2016) Yinjian Zhou et al.   Journal of Materials Chemistry B

Acute Myeloid Leukemia: A Concise Review

(2016) Jennifer Saultz et al.   Journal of Clinical Medicine

An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica

(2015) Erdenebileg Saruul et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1)

(2015) Jinlei Bian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Emerging therapeutic drugs for AML

(2015) E. M. Stein et al.   BLOOD

Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy

(2015) Xinpeng Ma et al.   JOURNAL OF CONTROLLED RELEASE

Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents

(2015) Gordon M. Cragg et al.   MEDICAL PRINCIPLES AND PRACTICE

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

(2015) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

5-Lipoxygenase Is a Candidate Target for Therapeutic Management of Stem Cell-like Cells in Acute Myeloid Leukemia

(2014) J. Roos et al.   CANCER RESEARCH

Investigational cancer drugs targeting cell metabolism in clinical development

(2014) Douglas W Sborov et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

New Horizons for Old Drugs and Drug Leads

(2014) Gordon M. Cragg et al.   JOURNAL OF NATURAL PRODUCTS

Cathepsin B: Multiple roles in cancer

(2014) Neha Aggarwal et al.   Proteomics Clinical Applications

A high-yielding CHO transient system: Coexpression of genes encoding EBNA-1 and GS enhances transient protein expression

(2013) Olalekan Daramola et al.   BIOTECHNOLOGY PROGRESS

Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates

(2013) Michael Ritchie et al.   mAbs

Lysosome Dysfunction Enhances Oxidative Stress-Induced Apoptosis through Ubiquitinated Protein Accumulation in Hela Cells

(2012) Chunyan Yu et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

(2012) Peter D Senter et al.   NATURE BIOTECHNOLOGY

Use of Solution-Phase Vibrational Frequencies in Continuum Models for the Free Energy of Solvation

(2011) Raphael F. Ribeiro et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Synthesis and antitumor activity of novel salvicine analogues

(2010) Fei Deng et al.   CHINESE CHEMICAL LETTERS

Products and mechanisms of photochemical transformations of o-quinones

(2010) M. P. Shurygina et al.   HIGH ENERGY CHEMISTRY

Continuous surface charge polarizable continuum models of solvation. I. General formalism

(2010) Giovanni Scalmani et al.   JOURNAL OF CHEMICAL PHYSICS

Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution

(2010) Jeremy R. Greenwood et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Self-immolative linkers in polymeric delivery systems

(2010) Christopher A. Blencowe et al.   Polymer Chemistry

Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions

(2009) Aleksandr V. Marenich et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

(2009) Yaoyu Chen et al.   NATURE GENETICS

Development of a 384-Well Colorimetric Assay to Quantify Hydrogen Peroxide Generated by the Redox Cycling of Compounds in the Presence of Reducing Agents

(2008) Paul A. Johnston et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Latent Fluorophores Based on a Self-Immolative Linker Strategy and Suitable for Protease Sensing†

(2008) Jean-Alexandre Richard et al.   BIOCONJUGATE CHEMISTRY

Red Lapacho (Tabebuia impetiginosa)—A global ethnopharmacological commodity?

(2008) J. Rubén Gómez Castellanos et al.   JOURNAL OF ETHNOPHARMACOLOGY

Long-range corrected hybrid density functionals with damped atom–atom dispersion corrections

(2008) Jeng-Da Chai et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Products of photoreduction of 9,10-phenanthrenequinone in the presence of N,N-dimethylanilines and polymethylbenzenes

(2007) M.P. Shurygina et al.   TETRAHEDRON