The RHIM of the Immune Adaptor Protein TRIF Forms Hybrid Amyloids with Other Necroptosis-Associated Proteins

Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death

(2022) Xin Chen et al.   NATURE CELL BIOLOGY

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

(2021) Hayley I. Muendlein et al.   Nature Communications

The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3

(2021) Xialian Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment

(2021) Humayun Sharif et al.   IMMUNITY

Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance

(2021) Laura Ramos Garcia et al.   Nature Communications

Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis

(2021) Zikou Liu et al.   EMBO JOURNAL

Viral manipulation of host cell necroptosis and pyroptosis

(2021) Simon Verdonck et al.   TRENDS IN MICROBIOLOGY

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

(2021) Yanxiang Meng et al.   Nature Communications

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila

(2020) Ruben Hervas et al.   SCIENCE

RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif

(2020) Hong Hu et al.   CELL DEATH AND DIFFERENTIATION

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

(2020) Andre L. Samson et al.   Nature Communications

Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death

(2020) Megan Steain et al.   PLoS Pathogens

Herpes simplex virus encoded ICP6 protein forms functional amyloid assemblies with necroptosis-associated host proteins

(2020) Nirukshan Shanmugam et al.   BIOPHYSICAL CHEMISTRY

Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation

(2019) Michael J. Holliday et al.   Nature Communications

Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

(2019) Junghyun Lim et al.   eLife

The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL)

(2019) James M. Murphy   Cold Spring Harbor Perspectives in Biology

Single-molecule detection on a portable 3D-printed microscope

(2019) James W. P. Brown et al.   Nature Communications

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

(2018) Miguel Mompeán et al.   CELL

RHIM-based protein:protein interactions in microbial defence against programmed cell death by necroptosis

(2018) Max O.D.G. Baker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1

(2018) Hongyan Guo et al.   Cell Death & Disease

Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies

(2018) Chi LL Pham et al.   EMBO REPORTS

TIR-domain-containing adapter-inducing interferon-β (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy

(2017) Ian E. Gentle et al.   FEBS Journal

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules

(2016) Hao Wu et al.   CELL

Evaluation of protease resistance and toxicity of amyloid-like food fibrils from whey, soy, kidney bean, and egg white

(2016) Moritz Lassé et al.   FOOD CHEMISTRY

TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

(2016) M. Obayed Ullah et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Herpes Simplex Virus Suppresses Necroptosis in Human Cells

(2015) Hongyan Guo et al.   Cell Host & Microbe

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

(2015) Michio Onizawa et al.   NATURE IMMUNOLOGY

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

(2015) Lorenzo Sborgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

RIPK1- and RIPK3-induced cell death mode is determined by target availability

(2014) W D Cook et al.   CELL DEATH AND DIFFERENTIATION

Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I

(2014) Bin Wu et al.   MOLECULAR CELL

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

(2014) Yann Gambin et al.   eLife

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species

(2014) Céline Vaure et al.   Frontiers in Immunology

Higher-Order Assemblies in a New Paradigm of Signal Transduction

(2013) Hao Wu   CELL

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

(2010) Liwei Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

E2 interaction and dimerization in the crystal structure of TRAF6

(2009) Qian Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sensing of Viral Infection and Activation of Innate Immunity by Toll-Like Receptor 3

(2008) E. Vercammen et al.   CLINICAL MICROBIOLOGY REVIEWS

Cytomegalovirus M45 Cell Death Suppression Requires Receptor-interacting Protein (RIP) Homotypic Interaction Motif (RHIM)-dependent Interaction with RIP1

(2008) Jason W. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY