Advances in Fibrin-Based Materials in Wound Repair: A Review

Plasminogen-Loaded Fibrin Scaffold as Drug Delivery System for Wound Healing Applications

(2022) Tamer Al Kayal et al.   Pharmaceutics

Fabrication and evaluation of Cs/PVP sponge containing platelet-rich fibrin as a wound healing accelerator: An in vitro and in vivo study

(2022) Mohamadreza Tavakoli et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

(2022) Ilker S. Bayer   Advanced Materials Interfaces

Anomalous mechanics of Zn2+-modified fibrin networks

(2021) Jing Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel fibrin functionalized multilayered electrospun nanofiber membrane for burn wound treatment

(2021) Md Eman Talukder et al.   Journal of Materials Science

Cellulose Nanocrystal–Fibrin Nanocomposite Hydrogels Promoting Myotube Formation

(2021) Kun Wang et al.   BIOMACROMOLECULES

Platelet heterogeneity enhances blood clot volumetric contraction: An example of asynchrono-mechanical amplification

(2021) Yueyi Sun et al.   BIOMATERIALS

Antiseptic povidone-iodine encapsulating edible phospholipid gels

(2021) Gözde Bayer et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Fibrin(ogen) as a Therapeutic Target: Opportunities and Challenges

(2021) Thembaninkosi G. Gaule et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Fibrin(ogen) in Wound Healing and Infection Control

(2021) Katherine J. Kearney et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Platelet-rich fibrin: An effective chronic wound healing accelerator

(2021) Fatma Bilgen et al.   Journal of Tissue Viability

Effects of Therapy with Fibrin Glue combined with Mesenchymal Stem Cells (MSCs) on Bone Regeneration: A Systematic Review

(2021) Adriana de Cássia Ortiz et al.   Cells

Physical and Mechanical Characterization of Fibrin-Based Bioprinted Constructs Containing Drug-Releasing Microspheres for Neural Tissue Engineering Applications

(2021) Ruchi Sharma et al.   Processes

Development of Vancomycin Delivery Systems Based on Autologous 3D Platelet-Rich Fibrin Matrices for Bone Tissue Engineering

(2021) Arita Dubnika et al.   Biomedicines

Strength, deformability and toughness of uncrosslinked fibrin fibers from theoretical reconstruction of stress-strain curves

(2021) Farkhad Maksudov et al.   Acta Biomaterialia

Leukocyte- and Platelet-Rich Fibrin: A New Method for Scalp Defect Reconstruction

(2021) Tim Van Cleemput et al.   DERMATOLOGIC SURGERY

Multiscale Characterization of the Mechanical Properties of Fibrin and Polyethylene Glycol (PEG) Hydrogels for Tissue Engineering Applications

(2021) Christian Jose Garcia Abrego et al.   MACROMOLECULAR CHEMISTRY AND PHYSICS

White matter regeneration induced by aligned fibrin nanofiber hydrogel contributes to motor functional recovery in canine T12 spinal cord injury

(2021) Zheng Cao et al.   Regenerative Biomaterials

A Review of Sustained Drug Release Studies from Nanofiber Hydrogels

(2021) Ilker S. Bayer   Biomedicines

3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres

(2020) Ruchi Sharma et al.   Frontiers in Bioengineering and Biotechnology

Evaluation of the optical and biomechanical properties of bioengineered human skin generated with fibrin-agarose biomaterials

(2020) Ana Maria Ionescu et al.   JOURNAL OF BIOMEDICAL OPTICS

Directional axonal regrowth induced by an aligned fibrin nanofiber hydrogel contributes to improved motor function recovery in canine L2 spinal cord injury

(2020) Zheng Cao et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Multiscale Network Modeling of Fibrin Fibers and Fibrin Clots with Protofibril Binding Mechanics

(2020) Sumith Yesudasan et al.   Polymers

Hyaluronic Acid and Controlled Release: A Review

(2020) Ilker S. Bayer   MOLECULES

Application of fibrin-based hydrogels for nerve protection and regeneration after spinal cord injury

(2020) Ziyuan Yu et al.   Journal of Biological Engineering

A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?

(2020) Agata Przekora   Cells

Targeting Tunable Physical Properties of Materials for Chronic Wound Care

(2020) Yuzhen Wang et al.   Frontiers in Bioengineering and Biotechnology

Fibrin hydrogel incorporated with graphene oxide functionalized nanocomposite scaffolds for bone repair — In vitro and in vivo study

(2020) Srinivetha Pathmanapan et al.   Nanomedicine-Nanotechnology Biology and Medicine

Novel fibrin-fibronectin matrix accelerates mice skin wound healing

(2020) Carlos Poblete Jara et al.   Bioactive Materials

Fibrin glue as a local drug-delivery system for bacteriophage PA5

(2019) Evgenii Rubalskii et al.   Scientific Reports

Poly(lactic-co-glycolic acid) microparticles in fibrin glue for local, sustained delivery of bupivacaine

(2019) Se-Na Kim et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

The Effect of Platelet-Rich Fibrin on Nasal Skin Thickness in Rhinoplasty

(2019) Sercan Gode et al.   FACIAL PLASTIC SURGERY

A two-layer skin construct consisting of a collagen hydrogel reinforced by a fibrin-coated polylactide nanofibrous membrane

(2019) Marketa Bacakova et al.   International Journal of Nanomedicine

Fibrin Gels Entrapment of a Poly-Cyclodextrin Nanocarrier as a Doxorubicin Delivery System in an Orthotopic Model of Neuroblastoma: Evaluation of In Vitro Activity and In Vivo Toxicity

(2019) Maurizio Viale et al.   PHARMACEUTICAL RESEARCH

Fibrin Matrices as (Injectable) Biomaterials: Formation, Clinical Use, and Molecular Engineering

(2019) Iwan Vaughan Roberts et al.   MACROMOLECULAR BIOSCIENCE

Evaluation of Drug Delivery and Efficacy of Ciprofloxacin-Loaded Povidone Foils and Nanofiber Mats in a Wound-Infection Model Based on Ex Vivo Human Skin

(2019) Rancan et al.   Pharmaceutics

Fibrin as a Multipurpose Physiological Platform for Bone Tissue Engineering and Targeted Delivery of Bioactive Compounds

(2019) Bruno Bujoli et al.   Pharmaceutics

In Situ Formed Fibrin Scaffold with Cyclophosphamide to Synergize with Immune Checkpoint Blockade for Inhibition of Cancer Recurrence after Surgery

(2019) Lin Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Recent advances in computational modeling of fibrin clot formation: A review

(2019) Sumith Yesudasan et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Fibrin-based delivery strategies for acute and chronic wound healing

(2018) P. Heher et al.   ADVANCED DRUG DELIVERY REVIEWS

Full-thickness human skin-on-chip with enhanced epidermal morphogenesis and barrier function

(2018) Gopu Sriram et al.   Materials Today

Characterization of drug release from fibrin gels loaded with different pharmaceutical and experimental doxorubicin formulations

(2018) Maurizio Viale et al.   Pharmacological Reports

Platelets in wound healing and regenerative medicine

(2018) Julia Etulain   PLATELETS

Injectable chitosan-fibrin/nanocurcumin composite hydrogel for the enhancement of angiogenesis

(2018) Annapoorna Mohandas et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Bioadhesive, Hemostatic, and Antibacterial in Situ Chitin–Fibrin Nanocomposite Gel for Controlling Bleeding and Preventing Infections at Mediastinum

(2018) M. Nivedhitha Sundaram et al.   ACS Sustainable Chemistry & Engineering

Fibrin-Modified Cellulose as a Promising Dressing for Accelerated Wound Healing

(2018) Marketa Bacakova et al.   Materials

Autologous fibrin scaffolds: When platelet- and plasma-derived biomolecules meet fibrin

(2018) Eduardo Anitua et al.   BIOMATERIALS

Quercetin impregnated chitosan–fibrin composite scaffolds as potential wound dressing materials — Fabrication, characterization and in vivo analysis

(2017) Weslen S. Vedakumari et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A review of fibrin and fibrin composites for bone tissue engineering

(2017) Alireza Noori et al.   International Journal of Nanomedicine

Fibrin mechanical properties and their structural origins

(2017) Rustem I. Litvinov et al.   MATRIX BIOLOGY

Nanofat-derived stem cells with platelet-rich fibrin improve facial contour remodeling and skin rejuvenation after autologous structural fat transplantation

(2017) Hua Wei et al.   Oncotarget

Controlled release of fibrin matrix-conjugated platelet derived growth factor improves ischemic tissue regeneration by functional angiogenesis

(2016) Rainer Mittermayr et al.   Acta Biomaterialia

Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering

(2016) Janahan Arulmoli et al.   Acta Biomaterialia

FIBRIN GEL AS A SCAFFOLD FOR SKIN SUBSTITUTE – PRODUCTION AND CLINICAL EXPERIENCE

(2016) Antun Kljenak   Acta Clinica Croatica

Fibrin Fiber Stiffness Is Strongly Affected by Fiber Diameter, but Not by Fibrinogen Glycation

(2016) Wei Li et al.   BIOPHYSICAL JOURNAL

Biomimetic interconnected porous keratin–fibrin–gelatin 3D sponge for tissue engineering application

(2016) Sivakumar Singaravelu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The potential applications of fibrin-coated electrospun polylactide nanofibers in skin tissue engineering

(2016) Marketa Bacakova et al.   International Journal of Nanomedicine

A comparative study of skin cell activities in collagen and fibrin constructs

(2016) Jia Xian Law et al.   MEDICAL ENGINEERING & PHYSICS

Evaluation of fibrin-based dermal-epidermal organotypic cultures for in vitro skin corrosion and irritation testing of chemicals according to OECD TG 431 and 439

(2016) Mariana Morales et al.   TOXICOLOGY IN VITRO

Role of Leukocyte–Platelet-Rich Fibrin in Endoscopic Endonasal Skull Base Surgery Defect Reconstruction

(2016) Liuba Soldatova et al.   Journal of Neurological Surgery Part B-Skull Base

Fibrin matrices: The versatile therapeutic delivery systems

(2015) Ejaj Ahmad et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fibrin gels loaded with cisplatin and cisplatin-hyaluronate complexes tested in a subcutaneous human melanoma model

(2015) Maurizio Viale et al.   INVESTIGATIONAL NEW DRUGS

Chitosan-Fibrin Nanocomposites as Drug Delivering and Wound Healing Materials

(2015) Weslen S. Vedakumari et al.   Journal of Biomedical Nanotechnology

Sustained dual drug delivery of anti-inhibitory molecules for treatment of spinal cord injury

(2015) Thomas S. Wilems et al.   JOURNAL OF CONTROLLED RELEASE

Modelling of platelet–fibrin clot formation in flow with a DPD–PDE method

(2015) A. Tosenberger et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Fibrin-based microsphere reservoirs for delivery of neurotrophic factors to the brain

(2015) Juhi Samal et al.   Nanomedicine

A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis

(2015) Leslie W. Chan et al.   Science Translational Medicine

The Use of Adipose Mesenchymal Stem Cells and Human Umbilical Vascular Endothelial Cells on a Fibrin Matrix for Endothelialized Skin Substitute

(2015) Isabel Sánchez-Muñoz et al.   TISSUE ENGINEERING PART A

Zwitterionic Nanofibers of Super-Glue for Transparent and Biocompatible Multi-Purpose Coatings

(2015) Elisa Mele et al.   Scientific Reports

Generation of a Fibrin Based Three-Layered Skin Substitute

(2015) Johanna Kober et al.   Biomed Research International

Use of the bovine pericardial patch and fibrin sealant in meningomyelocele closure

(2014) Bora Gürer et al.   ACTA NEUROCHIRURGICA

Physiologically clotted fibrin – Preparation and characterization for tissue engineering and drug delivery applications

(2014) Weslen S. Vedakumari et al.   BIOLOGICALS

Tissue-engineered dermo-epidermal skin grafts prevascularized with adipose-derived cells

(2014) Agnieszka S. Klar et al.   BIOMATERIALS

Tracheal reconstruction using chondrocytes seeded on a poly(l-lactic-co-glycolic acid)-fibrin/hyaluronan

(2014) Hyun Jun Hong et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Cell and biomolecule delivery for tissue repair and regeneration in the central nervous system

(2014) Irja Elliott Donaghue et al.   JOURNAL OF CONTROLLED RELEASE

Fibrin as a delivery system in wound healing tissue engineering applications

(2014) D. Whelan et al.   JOURNAL OF CONTROLLED RELEASE

Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164

(2014) V. Sacchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flexible, micro-porous chitosan–gelatin hydrogel/nanofibrin composite bandages for treating burn wounds

(2014) P. T. Sudheesh Kumar et al.   RSC Advances

Fibrin-based scaffold incorporating VEGF- and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice

(2013) Paola Losi et al.   Acta Biomaterialia

Fibrin-based biomaterials: Modulation of macroscopic properties through rational design at the molecular level

(2013) Ashley C. Brown et al.   Acta Biomaterialia

Fibrin nanoparticles as Possible vehicles for drug delivery

(2013) Weslen S. Vedakumari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mechanisms of fibrin polymerization and clinical implications

(2013) J. W. Weisel et al.   BLOOD

Human adipose stromal vascular cell delivery in a fibrin spray

(2013) Ludovic Zimmerlin et al.   CYTOTHERAPY

A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs

(2013) Eva Filová et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bilayer Hydrogel With Autologous Stem Cells Derived From Debrided Human Burn Skin for Improved Skin Regeneration

(2013) Shanmugasundaram Natesan et al.   Journal of Burn Care & Research

Antimicrobial Drugs Encapsulated in Fibrin Nanoparticles for Treating Microbial Infested Wounds

(2013) B. Maria Alphonsa et al.   PHARMACEUTICAL RESEARCH

Strain history dependence of the nonlinear stress response of fibrin and collagen networks

(2013) S. Munster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Safe and Efficient Method to Retrieve Mesenchymal Stem Cells from Three-Dimensional Fibrin Gels

(2013) Bita Carrion et al.   TISSUE ENGINEERING PART C-METHODS

Approaches to synthetic platelet analogs

(2012) Christa L. Modery-Pawlowski et al.   BIOMATERIALS

α−α Cross-Links Increase Fibrin Fiber Elasticity and Stiffness

(2012) Christine C. Helms et al.   BIOPHYSICAL JOURNAL

Fibrin nanoconstructs: a novel processing method and their use as controlled delivery agents

(2012) G Praveen et al.   NANOTECHNOLOGY

Fibrin Clots Are Equilibrium Polymers That Can Be Remodeled Without Proteolytic Digestion

(2012) Irina N. Chernysh et al.   Scientific Reports

A PEGylated fibrin-based wound dressing with antimicrobial and angiogenic activity

(2011) Shanmuganathan Seetharaman et al.   Acta Biomaterialia

Fibrin Clot Structure and Function

(2011) Anetta Undas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autologous fibrin scaffolds cultured dermal fibroblasts and enriched with encapsulated bFGF for tissue engineering

(2011) Pilar de la Puente et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A fibrin gel loaded with chitosan nanoparticles for local delivery of rhEGF: preparation and in vitro release studies

(2011) Wenjun Zhou et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Mechanical properties of blood clots - a new test method. Mechanische Eigenschaften von Thromben - Neue Untersuchungsmethoden

(2011) N. Krasokha et al.   MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK

Correlation between fibrin network structure and mechanical properties: an experimental and computational analysis

(2011) Eunjung Kim et al.   Soft Matter

Tissue response to poly(ether)urethane-polydimethylsiloxane-fibrin composite scaffolds for controlled delivery of pro-angiogenic growth factors

(2010) Paola Losi et al.   BIOMATERIALS

The molecular origins of the mechanical properties of fibrin

(2010) Michael R. Falvo et al.   BIOPHYSICAL CHEMISTRY

The interplay between tissue plasminogen activator domains and fibrin structures in the regulation of fibrinolysis: kinetic and microscopic studies

(2010) C. Longstaff et al.   BLOOD

Controlled Release of Neurotrophin-3 and Platelet-Derived Growth Factor from Fibrin Scaffolds Containing Neural Progenitor Cells Enhances Survival and Differentiation into Neurons in a Subacute Model of SCI

(2010) Philip J. Johnson et al.   CELL TRANSPLANTATION

Rheological properties of peptide-based hydrogels for biomedical and other applications

(2010) Congqi Yan et al.   CHEMICAL SOCIETY REVIEWS

Bio-printing of collagen and VEGF-releasing fibrin gel scaffolds for neural stem cell culture

(2010) Yeong-Bae Lee et al.   EXPERIMENTAL NEUROLOGY

The mechanical properties of single fibrin fibers

(2010) W. Liu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Tissue-engineered fibrin scaffolds containing neural progenitors enhance functional recovery in a subacute model of SCI

(2010) Philip J. Johnson et al.   Soft Matter

Nanostructuring of PEG–fibrinogen polymeric scaffolds

(2009) Ilya Frisman et al.   Acta Biomaterialia

Cell-controlled and spatially arrayed gene delivery from fibrin hydrogels

(2009) Pedro Lei et al.   BIOMATERIALS

Controlled release of substances bound to fibrin-anchors or of DNA

(2009) T. J. Morton et al.   DRUG DELIVERY

A review of tissue-engineered skin bioconstructs available for skin reconstruction

(2009) R. V. Shevchenko et al.   Journal of the Royal Society Interface

Tissue-engineered allograft tracheal cartilage using fibrin/hyaluronan composite gel and its in vivo implantation

(2009) Dong Young Kim et al.   LARYNGOSCOPE

Fibrin network structure and clot mechanical properties are altered by incorporation of erythrocytes

(2009) Kathryn Gersh et al.   THROMBOSIS AND HAEMOSTASIS

In Vivo Remodeling and Structural Characterization of Fibrin-Based Tissue-Engineered Heart Valves in the Adult Sheep Model

(2009) Thomas C. Flanagan et al.   TISSUE ENGINEERING PART A

Heparin-Conjugated Fibrin as an Injectable System for Sustained Delivery of Bone Morphogenetic Protein-2

(2009) Hee Seok Yang et al.   TISSUE ENGINEERING PART A

Fibrin as a Delivery System for Therapeutic Drugs and Biomolecules

(2009) Ailish Breen et al.   TISSUE ENGINEERING PART B-REVIEWS

Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering

(2008) Thanaphum Osathanon et al.   BIOMATERIALS

Liposomes/Chitosan Scaffold/Human Fibrin Gel Composite Systems for Delivering Hydrophilic Drugs—Release Behaviors of TirofibanIn Vitro

(2008) Shoi-Shen Wang et al.   DRUG DELIVERY

Fibrin gels and their clinical and bioengineering applications

(2008) P. A Janmey et al.   Journal of the Royal Society Interface

Enhancing Efficacy of Stem Cell Transplantation to the Heart with a PEGylated Fibrin Biomatrix

(2008) Ge Zhang et al.   TISSUE ENGINEERING PART A

Fibrin: A Versatile Scaffold for Tissue Engineering Applications

(2008) Tamer A.E. Ahmed et al.   TISSUE ENGINEERING PART B-REVIEWS