CYP450 Epoxygenase Metabolites, Epoxyeicosatrienoic Acids, as Novel Anti-Inflammatory Mediators

Soluble Epoxide Hydrolase Inhibition Protected against Diabetic Cardiomyopathy through Inducing Autophagy and Reducing Apoptosis Relying on Nrf2 Upregulation and Transcription Activation

(2022) Qin Fang et al.   Oxidative Medicine and Cellular Longevity

Endothelial Nox4 dysfunction aggravates atherosclerosis by inducing endoplasmic reticulum stress and soluble epoxide hydrolase

(2021) Weimin Yu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats

(2021) Md. Abdul Hye Khan et al.   BRITISH JOURNAL OF PHARMACOLOGY

EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model

(2021) Tongtong Liu et al.   Journal of Neuroinflammation

Epigenetic Regulation of Vascular Smooth Muscle Cell Phenotype Switching in Atherosclerotic Artery Remodeling: A Mini-Review

(2021) Michelle Zurek et al.   Frontiers in Genetics

Targeting Soluble Epoxide Hydrolase and Cyclooxygenases Enhance Joint Pain Control, Stimulate Collagen Synthesis, and Protect Chondrocytes From Cytokine-Induced Apoptosis

(2021) Laura Tucker et al.   Frontiers in Veterinary Science

Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis

(2021) Fangyu Du et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Clinical and preclinical evidence for roles of soluble epoxide hydrolase in osteoarthritis knee pain

(2021) Peter R. W. Gowler et al.   Arthritis & Rheumatology

COX-2/sEH Dual Inhibitor PTUPB Alleviates CCl4-Induced Liver Fibrosis and Portal Hypertension

(2021) Zhifeng Zhao et al.   Frontiers in Medicine

PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice

(2020) Chen-Chen Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model

(2020) Carlos A. Trindade‐da‐Silva et al.   FASEB JOURNAL

CYP2J2-produced epoxyeicosatrienoic acids attenuate ischemia/reperfusion-induced acute kidney injury by activating the SIRT1-FoxO3a pathway

(2020) Ye Zhu et al.   LIFE SCIENCES

Inhibition of soluble epoxide hydrolase attenuates renal tubular mitochondrial dysfunction and ER stress by restoring autophagic flux in diabetic nephropathy

(2020) Xu-shun Jiang et al.   Cell Death & Disease

A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress

(2020) Yan-Feng Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats

(2020) Juliana Maia Teixeira et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Soluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy

(2020) Luyun Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Epoxyeicosatrienoic acids improve glucose homeostasis by preventing NF-κB-mediated transcription of SGLT2 in renal tubular epithelial cells

(2020) Menglu Fu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study

(2019) Sheng Li et al.   Science China-Life Sciences

A synthetic epoxyeicosatrienoic acid analog prevents the initiation of ischemic acute kidney injury

(2019) Uwe Hoff et al.   Acta Physiologica

Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation

(2019) Sean D. Kodani et al.   BIOCHIMIE

Diabetic Cardiomyopathy

(2019) Wolfgang H. Dillmann   CIRCULATION RESEARCH

Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis

(2019) Francisco J Rios et al.   CARDIOVASCULAR RESEARCH

Epoxyeicosatrienoic intervention improves NAFLD in leptin receptor deficient mice by an increase in HO-1-PGC1α mitochondrial signaling

(2019) Marco Raffaele et al.   EXPERIMENTAL CELL RESEARCH

sEH Inhibitor TPPU Ameliorates Cecal Ligation and Puncture-Induced Sepsis by Regulating Macrophage Functions

(2019) Zhihui Chen et al.   SHOCK

Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis

(2019) Cindy B. McReynolds et al.   Frontiers in Pharmacology

New Lipid Mediators in Retinal Angiogenesis and Retinopathy

(2019) Ingrid Fleming   Frontiers in Pharmacology

Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation

(2019) Mythili Dileepan et al.   Frontiers in Pharmacology

Epoxyeicosatrienoic acids protect pancreatic beta cells against pro-inflammatory cytokine toxicity

(2019) Daniel Grimes et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of soluble epoxide hydrolase attenuates airway remodeling in a chronic asthma model

(2019) Jun-xia Jiang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Adenosine 2A Receptor Activation Contributes to Ang II–Induced Aortic Remodeling by Promoting Macrophage Retention

(2019) Zuowen He et al.   HYPERTENSION

CYP2J2-derived EETs attenuated ethanol-induced myocardial dysfunction through inducing autophagy and reducing apoptosis

(2018) Chi Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Downregulated Serum 14, 15-Epoxyeicosatrienoic Acid Is Associated With Abdominal Aortic Calcification in Patients With Primary AldosteronismNovelty and Significance

(2018) Pinming Liu et al.   HYPERTENSION

Effect of Soluble Epoxide Hydrolase in Hyperoxic Acute Lung Injury in Mice

(2018) Ping-Song Li et al.   INFLAMMATION

Effects of Farnesoid X Receptor Activation on Arachidonic Acid Metabolism, NF-kB Signaling, and Hepatic Inflammation

(2018) Zhibo Gai et al.   MOLECULAR PHARMACOLOGY

Soluble epoxide hydrolase inhibition with t-TUCB alleviates liver fibrosis and portal pressure in carbon tetrachloride-induced cirrhosis in rats

(2018) Chi-Hao Zhang et al.   Clinics and Research in Hepatology and Gastroenterology

Deletion of soluble epoxide hydrolase attenuates mice Hyperoxic acute lung injury

(2018) Li-Ping Liu et al.   BMC Anesthesiology

Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling

(2018) Qinshuo Zhao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases

(2018) Thomas Sonnweber et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury

(2017) Ahmed Bettaieb et al.   FEBS Journal

Montelukast Induces Apoptosis-Inducing Factor-Mediated Cell Death of Lung Cancer Cells

(2017) Ming-Ju Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα 12/13

(2017) Zuowen He et al.   JOURNAL OF LIPID RESEARCH

Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases

(2017) Karen M. Wagner et al.   PHARMACOLOGY & THERAPEUTICS

Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling

(2017) Bing-Qing Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis

(2017) Wensheng Deng et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice

(2017) Yong Zhou et al.   SHOCK

Soluble Epoxide Hydrolase Plays a Vital role In Angiotensin II-Induced Lung Injury in Mice

(2017) Wei Tao et al.   SHOCK

Soluble epoxide hydrolase inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways

(2017) Xin-wei Dong et al.   TOXICOLOGY

CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue

(2017) Meiyan Dai et al.   Scientific Reports

Soluble Epoxide Hydrolase Inhibition Protected against Angiotensin II-induced Adventitial Remodeling

(2017) Chi Zhou et al.   Scientific Reports

CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPKα2 and enhancing nuclear translocation of Akt1

(2016) Bei Wang et al.   AGING CELL

14,15-Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy

(2016) Yunxiao Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette Smoke-Induced Pulmonary Inflammation and Autophagy Are Attenuated in Ephx2-Deficient Mice

(2016) Yunxiao Li et al.   INFLAMMATION

Soluble Epoxide Hydrolase Inhibitor Suppresses the Expression of Triggering Receptor Expressed on Myeloid Cells-1 by Inhibiting NF-kB Activation in Murine Macrophage

(2016) Liang Dong et al.   INFLAMMATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CYP2J2 Overexpression Increases EETs and Protects Against HFD-Induced Atherosclerosis in ApoE−/− Mice

(2016) Wanjun Liu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr−/− mice

(2016) Dan Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Epoxyeicosatrienoic Acids Regulate Adipocyte Differentiation of Mouse 3T3 Cells, Via PGC-1α Activation, Which Is Required for HO-1 Expression and Increased Mitochondrial Function

(2016) Maayan Waldman et al.   STEM CELLS AND DEVELOPMENT

CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPARγ

(2015) Rui Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice

(2015) Clothilde Roche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Soluble Epoxide Hydrolase Inhibitor Attenuates Inflammation and Airway Hyperresponsiveness in Mice

(2015) Jun Yang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Down-regulation of EPHX2 gene transcription by Sp1 under high-glucose conditions

(2015) A. Oguro et al.   BIOCHEMICAL JOURNAL

Cardiomyocyte-specific expression of CYP2J2 prevents development of cardiac remodelling induced by angiotensin II

(2015) Zuowen He et al.   CARDIOVASCULAR RESEARCH

Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice

(2015) Yong Zhou et al.   CELL AND TISSUE RESEARCH

Epoxyeicosatrienoic Acids Regulate Macrophage Polarization and Prevent LPS-Induced Cardiac Dysfunction

(2015) Meiyan Dai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epoxyeicosanoid Signaling Provides Multi-target Protective Effects on Neurovascular Unit in Rats After Focal Ischemia

(2015) Yang Liu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury

(2015) Xiaojing Chen et al.   MOLECULAR NEUROBIOLOGY

Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway

(2015) Jian Cao et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells

(2015) Wen-jiang Ma et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice

(2015) Todd R. Harris et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume

(2014) Chi Young Shim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CYP2J2 and EETs Protect against Oxidative Stress and Apoptosisin Vivoandin VitroFollowing Lung Ischemia/Reperfusion

(2014) Wenshu Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Type 1 Diabetes Mellitus and Cardiovascular Disease: A Scientific Statement From the American Heart Association and American Diabetes Association

(2014) Sarah D. de Ferranti et al.   DIABETES CARE

Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity

(2014) Weibin Zha et al.   JOURNAL OF LIPID RESEARCH

Human cytochrome P450 epoxygenases: Variability in expression and role in inflammation-related disorders

(2014) Payman Shahabi et al.   PHARMACOLOGY & THERAPEUTICS

Opposite Effects of Gene Deficiency and Pharmacological Inhibition of Soluble Epoxide Hydrolase on Cardiac Fibrosis

(2014) Lijuan Li et al.   PLoS One

Vascular Complications of Diabetes: Mechanisms of Injury and Protective Factors

(2013) Christian Rask-Madsen et al.   Cell Metabolism

Influence of inflammation on cardiovascular protective effects of cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids

(2013) Payman Shahabi et al.   DRUG METABOLISM REVIEWS

Cardiac-Specific Overexpression of CYP2J2 Attenuates Diabetic Cardiomyopathy in Male Streptozotocin-Induced Diabetic Mice

(2013) Ben Ma et al.   ENDOCRINOLOGY

CYP2J3 Gene Delivery Up-Regulated Adiponectin Expression via Reduced Endoplasmic Reticulum Stress in Adipocytes

(2013) Xizhen Xu et al.   ENDOCRINOLOGY

Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue

(2013) Ahmed Bettaieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CYP2J2 overexpression increases EETs and protects against angiotensin II-induced abdominal aortic aneurysm in mice

(2013) Zhejun Cai et al.   JOURNAL OF LIPID RESEARCH

CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy

(2013) Christina Westphal et al.   PLoS One

Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health

(2012) Christophe Morisseau et al.   Annual Review of Pharmacology and Toxicology

Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease

(2012) Katherine N. Theken et al.   ATHEROSCLEROSIS

Efficacy and safety of 15(R/S)-methyl-lipoxin A4in topical treatment of infantile eczema

(2012) S.-H. Wu et al.   BRITISH JOURNAL OF DERMATOLOGY

Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy

(2012) Hassan N Althurwi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Diagnosis and Classification of Diabetes Mellitus

(2012)   DIABETES CARE

Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury

(2012) Gang Zhao et al.   JOURNAL OF LIPID RESEARCH

Inhibition of Soluble Epoxide Hydrolase Attenuates High-Fat-Diet–Induced Hepatic Steatosis by Reduced Systemic Inflammatory Status in Mice

(2012) Yan Liu et al.   PLoS One

Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1

(2012) J. E. Kanter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice

(2012) Rui Li et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases

(2011) Xizhen Xu et al.   ADVANCED DRUG DELIVERY REVIEWS

Use of a Soluble Epoxide Hydrolase Inhibitor in Smoke-Induced Chronic Obstructive Pulmonary Disease

(2011) Lei Wang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: Photoaffinity Labeling of a 14,15-Epoxyeicosatrienoic Acid Receptor

(2011) Yuenmu Chen et al.   BIOCHEMISTRY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance

(2011) A. Luria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice

(2011) Guangzhi Chen et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syndrome complications

(2011) Angela Burgess et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Soluble Epoxide Hydrolase in Atherosclerosis

(2010) Yi-Xin Jim Wang et al.   Current Atherosclerosis Reports

Increased CYP2J3 Expression Reduces Insulin Resistance in Fructose-Treated Rats and db/db Mice

(2010) X. Xu et al.   DIABETES

Epoxyeicosatrienoic Acid Agonist Regulates Human Mesenchymal Stem Cell–Derived Adipocytes Through Activation of HO-1-pAKT Signaling and a Decrease in PPARγ

(2010) Dong Hyun Kim et al.   STEM CELLS AND DEVELOPMENT

Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity

(2009) Yunfang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of Soluble Epoxide Hydrolase Attenuated Atherosclerosis, Abdominal Aortic Aneurysm Formation, and Dyslipidemia

(2009) Le-Ning Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of Soluble Epoxide Hydrolase (sEH) in Mice with Diabetes: High Glucose Suppresses sEH Expression

(2009) Ami Oguro et al.   Drug Metabolism and Pharmacokinetics

Thematic Review Series: Proteomics.An integrated omics analysis of eicosanoid biology,

(2009) Matthew W. Buczynski et al.   JOURNAL OF LIPID RESEARCH

Epoxyeicosatrienoic Acid Agonist Rescues the Metabolic Syndrome Phenotype of HO-2-Null Mice

(2009) K. Sodhi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

(2009) John D. Imig et al.   NATURE REVIEWS DRUG DISCOVERY

Expression and Regulation of Soluble Epoxide Hydrolase in Adipose Tissue

(2009) Bart M. De Taeye et al.   Obesity

Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy

(2009) D. Ai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eicosanoid signalling pathways in the heart

(2008) C. M. Jenkins et al.   CARDIOVASCULAR RESEARCH

Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase

(2008) Alan R. Parrish et al.   CELL BIOLOGY AND TOXICOLOGY

Soluble Epoxide Hydrolase Inhibitors Reduce the Development of Atherosclerosis in Apolipoprotein E-Knockout Mouse Model

(2008) Arzu Ulu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-κβ in hyperhomocysteinemia

(2008) Karni S. Moshal et al.   JOURNAL OF CELLULAR PHYSIOLOGY