Review
Biochemistry & Molecular Biology
Ramon Farre, Isaac Almendros, Miguel-Angel Martinez-Garcia, David Gozal
Summary: This review focuses on the experimental models used to study the consequences of sleep apnea (SA), including cell culture systems, animal models, and human SA models. The advantages, limitations, and relevant findings of these models are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Eun Bok Baek, Yu Jin Kim, Jin-Hyung Rho, Eun-Ju Hong, Mee-Young Lee, Hyo-Jung Kwun
Summary: The study found that Gyeji-tang significantly suppressed lung inflammation and airway remodeling induced by cigarette smoke and lipopolysaccharide exposure, suggesting its potential therapeutic effect on chronic obstructive pulmonary disease.
PHARMACEUTICAL BIOLOGY
(2022)
Review
Virology
Salma Younes, Nadin Younes, Farah Shurrab, Gheyath K. Nasrallah
Summary: This systematic review compiled and discussed studies on SARS-CoV-2 infection in animals, identifying fruit bats, pangolins, felines, mink, ferrets, and rabbits as susceptible to the virus. Models such as mice, mink, hamsters, and ferrets may resemble subclinical human infection, making them useful for studying vaccines and antiviral agents. The findings provide valuable insights for future research on vaccine development and therapeutic agents for managing diseases caused by SARS-CoV-2.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Article
Nutrition & Dietetics
Yang Cai, Myrthe S. Gilbert, Walter J. J. Gerrits, Gert Folkerts, Saskia Braber
Summary: Fructo-oligosaccharides (FOS) demonstrated anti-inflammatory properties in preventing calf lung infections, increasing macrophage numbers, reducing certain cytokine concentrations, and alleviating lung lesions, though without affecting clinical scores.
Review
Respiratory System
Thomas Glaab, Armin Braun
Summary: Using noninvasive head-out body plethysmography for measuring lung function in mice allows accurate assessment of airway responsiveness without anesthesia and with easy repeatability. EF50 as a marker of airflow limitation shows good agreement with invasive measurements, suitable for simple screening in large-scale studies and investigating the impact of respiratory infections on lung physiology in laboratory mice.
Article
Plant Sciences
Ami Lee, You Chul Chung, Kwang Hoon Song, Jin Ah Ryuk, Hyunil Ha, Youth Hwan Hwang
Summary: The seeds of Psoralea corylifolia L. have been used in traditional oriental medicine to treat various diseases. This study found that the hydroethanolic extract of Psoralea corylifolia L. has therapeutic effects against inflammatory bowel disease in mice, and identified the bioactive components responsible for its anti-inflammatory effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Abayomi M. Ajayi, Adekunle I. Coker, Oyetola T. Oyebanjo, Iyanuoluwa Mary Adebanjo, Olusegun G. Ademowo
Summary: Pineapple peel extract demonstrated mild antimalarial activity but significant antinociceptive and anti-inflammatory properties, possibly through inhibition of pro-inflammatory mediators.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Yun Mao, Sonika Patial, Yogesh Saini
Summary: This study investigated the role of airway epithelium-specific HMGB1 in the pathogenesis of muco-obstructive lung disease in Tg+ mice. The deficiency of HMGB1 in airway epithelial cells in Tg+ mice resulted in increased inflammation and impaired bacterial clearance.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Wojcik-Pszczola, Agnieszka Jankowska, Marietta Slusarczyk, Bogdan Jakiela, Hanna Plutecka, Krzysztof Pociecha, Artur Swierczek, Justyna Popiol, Paulina Koczurkiewicz-Adamczyk, Elzbieta Wyska, Elzbieta Pekala, Reinoud Gosens, Grazyna Chlon-Rzepa
Summary: Phosphodiesterase inhibitors have shown promise in treating inflammatory and fibrotic diseases, including asthma. The novel compounds described in the study exhibited antioxidant and anti-inflammatory activity, reducing the expression of inflammatory and fibrotic mediators in bronchial epithelial cells. These dual-acting pan-PDE inhibitors have potential as lead structures for future anti-asthmatic agent discovery.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Feng Lei, Zhou Yan
Summary: Pain is becoming a major global health issue, affecting one in every five adults worldwide each year. In this study, the antinociceptive and anti-inflammatory effects of corynoline, a phytochemical compound isolated from Corydalis bungeana Turcz., were evaluated in experimental mice. The results showed that corynoline significantly reduced pain and inflammation in a dose-dependent manner.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Ibrahim Taher, Eman El-Masry, Mohamed Abouelkheir, Ahmed E. Taha
Summary: Cytokine storm is a major cause of death in COVID-19 patients, and metformin has been shown to inhibit proinflammatory cytokines. This study examined the anti-inflammatory effect of oral and intraperitoneal metformin in a mouse model of LPS-induced cytokine storm. Both routes of metformin administration significantly reduced IL-1, IL-6, and TNF-alpha levels, with intraperitoneal metformin being more effective in reducing IL-6 levels. Metformin shows potential in ameliorating diseases caused by elevated cytokine levels.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Clinical Neurology
Maria Gabriella Buzzi
Summary: Animal models have been widely used to understand the mechanisms and develop therapeutic agents for migraine. They can be categorized into two types: vascular and neurovascular. Vascular models measure the protein leakage from vessels and evaluate the efficacy of therapeutic agents. Neurovascular models activate the trigemino-vascular system and evaluate Fos expression in the central nociceptive pathway.
NEUROLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Adrienn Markovics, Ken S. Rosenthal, Katalin Mikecz, Roy E. Carambula, Jason C. Ciemielewski, Daniel H. Zimmerman
Summary: This review discusses the current immunotherapies for rheumatoid arthritis, including disease-modifying anti-rheumatic drugs, Janus kinase inhibitors, and therapeutic vaccines using the LEAPS vaccine approach, and how these methods modulate the immune system.
Article
Engineering, Biomedical
Mariana de Souza Costa, Tarcisio Vieira de Brito, Saul Barbosa de Oliveira, Isabela de Souza Brauna, Jose Carlos Rapozo Mazulo Neto, Ramon Handerson Gomes Teles, Yago Medeiros Dutra, Diva de Aguiar Magalhaes, Stefany Guimaraes Sousa, Janyere Alexandrino de Sousa, Carlos Eduardo Rodrigues Castelo Branco, Fuad Ahmad Hazime, Andre Luiz dos Reis Barbosa, Daniel Fernando Pereira Vasconcelos, Jand Venes Rolim Medeiros, Marcelo de Carvalho Filgueiras
Summary: Photobiomodulation therapy (PBMT) is a non-thermal therapeutic procedure used in clinical practice for treating various inflammatory conditions with fewer adverse effects compared to conventional therapy. This study investigated the effects of two different doses of PBMT on experimental models of inflammation, showing that 1 J/cm(2) of PBMT improved paw edema and reduced histological scores induced by phlogistic agents. PBMT at 1 J/cm(2) also demonstrated beneficial effects on carrageenan-induced edema and inhibited neutrophil migration.
LASERS IN MEDICAL SCIENCE
(2022)
Review
Oncology
Jing Li, Xin Wang, Mudan Ren, Shuixiang He, Yan Zhao
Summary: Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. Animal models play a crucial role in studying the pathogenesis and drug development for HCC. This review provides a comprehensive summary of the classification, characteristics, and advances in experimental animal models of HCC, serving as a reference for researchers in model selection.
Article
Chemistry, Analytical
Kai Wang, Natalia Vasylieva, Debin Wan, David A. Eads, Jun Yang, Tyler Tretten, Bogdan Barnych, Ji Li, Qing X. Li, Shirley J. Gee, Bruce D. Hammock, Ting Xu
ANALYTICAL CHEMISTRY
(2019)
Article
Environmental Sciences
Wuqun Tao, Jijing Tian, Tuan Xu, Li Xu, Heidi Qunhui Xie, Zhiguang Zhou, Zhiling Guo, Hualing Fu, Xuejiao Yin, Yangsheng Chen, Haiming Xu, Songyan Zhang, Wanglong Zhang, Chao Ma, Feng Ji, Jun Yang, Bin Zhao
ENVIRONMENTAL POLLUTION
(2019)
Article
Chemistry, Medicinal
Bruce D. Hammock, Cindy B. McReynolds, Karen Wagner, Alan Buckpitt, Irene Cortes-Puch, Glenn Croston, Kin Sing Stephen Lee, Jun Yang, William K. Schmidt, Sung Hee Hwang
Summary: This report describes the development of an orally active analgesic that can address inflammation and neuropathic pain without causing addiction. The medication stabilizes EpFA to reduce pain and inflammation, with human trials showing no drug-related adverse events. Additionally, the fundamental research leading to the discovery of this medication and its mechanism of action is outlined.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Debin Wan, Christophe Morisseau, Bruce D. Hammock, Jun Yang
Summary: Vicinal diols, important signaling metabolites in inflammatory diseases, can be profiled using the LC-PCD-DPIS-MS method. This method offers improved selectivity and sensitivity compared to traditional derivatization techniques and full scan MS methods. It retains the separation capacity of liquid chromatography and allows for easy identification of vicinal-diol metabolites.
Article
Multidisciplinary Sciences
Jianjun Deng, Haixia Yang, Victoria M. Haak, Jun Yang, Franciele C. Kipper, Chantal Barksdale, Sung Hee Hwang, Allison Gartung, Diane R. Bielenberg, Selvakumar Subbian, Koc-Kan Ho, Xiang Ye, Daidi Fan, Yongkui Sun, Bruce D. Hammock, Dipak Panigrahy
Summary: Chemotherapy-generated tumor cell debris stimulates metastasis by upregulating sEH and EP4, triggering an inflammatory response. Inhibiting both sEH and EP4 eicosanoid pathways can prevent metastasis and tumor growth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Jingyi Xu, Xing Qiu, Gary Yu, Maria Ly, Jun Yang, Rona M. Silva, Xun Zhang, Mang Yu, Yinong Wang, Bruce Hammock, Kent E. Pinkerton, Dewei Zhao
Summary: Exposure to tobacco smoke has been linked to osteonecrosis of the femoral head, with soluble epoxide hydrolase inhibitors potentially offering protective effects, particularly in hypertensive rats.
Article
Biochemistry & Molecular Biology
Mayra Montecillo-Aguado, Belen Tirado-Rodriguez, Gabriela Antonio-Andres, Mario Morales-Martinez, Zhen Tong, Jun Yang, Bruce D. Hammock, Rogelio Hernandez-Pando, Sara Huerta-Yepez
Summary: Lung cancer is the leading cause of cancer death worldwide, and the intake of omega-6 polyunsaturated fatty acids (PUFAs) in the diet is associated with increased cancer risk and progression. This study found that a diet rich in omega-6 PUFAs enhances the malignancy of tumor cells, promoting cell proliferation, angiogenesis, and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nhien Nguyen, Christophe Morisseau, Dongyang Li, Jun Yang, Eileen Lam, D. Blake Woodside, Bruce D. Hammock, Pei-an Betty Shih
Summary: This study investigated the expression and activity of soluble epoxide hydrolase (sEH) in healthy women and women with anorexia nervosa. The results showed a correlation between sEH and body mass index, as well as a complex relationship with age and anxiety.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Weicang Wang, Yuxin Wang, Jun Yang, Karen M. Wagner, Sung Hee Hwang, Jeff Cheng, Nalin Singh, Patricia Edwards, Christophe Morisseau, Guodong Zhang, Dipak Panigrahy, Bruce D. Hammock
Summary: Aflatoxin B1 (AFB1) contamination in food and feed causes serious health problems worldwide. This study found that AFB1 disrupts intestinal immune function by suppressing macrophages, especially M2 macrophages, and antimicrobial peptide-secreting Paneth cells. The study also identified that AFB1 immunotoxicity is associated with decreased epoxy fatty acids and increased soluble epoxide hydrolase (sEH) levels in the intestine. Furthermore, sEH deficiency or inhibition rescued the compromised intestinal immunity caused by AFB1 exposure. Overall, this study demonstrates the potential application of inhibiting the sEH enzyme to alleviate AFB1-induced intestinal immunotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Weicang Wang, Karen M. M. Wagner, Yuxin Wang, Nalin Singh, Jun Yang, Qiyi He, Christophe Morisseau, Bruce D. D. Hammock
Summary: Aging colon leads to systemic inflammation and disorders in multiple organs, but the detailed mechanisms and regulators of colon aging are largely unknown. This study found that the expression and activity of sEH enzyme are increased in aged mice colon. Knockout of sEH attenuated age-related upregulation of senescent markers and ER stress, highlighting sEH as a potential therapeutic target for age-related colon diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Huiyi Yang, Meng Qi, Qiyi He, Sung Hee Hwang, Jun Yang, Mark Mccoy, Christophe Morisseau, Suqing Zhao, Bruce D. Hammock
Summary: This study developed a nanobody-based enzyme-linked immunosorbent assay (ELISA) for accurate quantification of drug compounds. The assay showed excellent correlation with liquid chromatography mass spectrometry (LC-MS) analysis and can be easily implemented for monitoring small molecule medicines during clinical development and therapy.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Qing Shen, Jun Yang, Daisy Zamora, Mark Horowitz, Keturah R. Faurot, Beth A. MacIntosh, J. Douglas Mann, Bruce D. Hammock, Christopher E. Ramsden, Ameer Y. Taha
Summary: A previous study showed that reducing dietary omega-6 linoleic acid (LA) while increasing omega-3 polyunsaturated fatty acid (PUFA) intake reduced headache frequency and improved quality of life in chronic headache patients. This secondary analysis investigated if these clinical benefits were related to changes in plasma unesterified PUFA-derived lipid mediators associated with pain. The study found that reducing LA intake did not alter these lipid mediators, but elevated levels of DHA-epoxides were associated with reduced headache frequency and improved quality of life.
Article
Biochemistry & Molecular Biology
Young Taek Oh, Jun Yang, Christophe Morisseau, Qiyi He, Bruce Hammock, Jang H. Youn
Summary: Oxylipins, which are oxidation products of unsaturated free fatty acids (FFAs), play important roles in cellular signaling systems. FFA epoxides, a type of oxylipin, have beneficial effects on metabolic and cardiovascular health. This study examined the effects of increased FFAs on various oxylipins, particularly epoxides, diols, and their ratios. The results showed that while raising plasma FFAs increased hepatic and plasma epoxide and diol levels, it did not significantly affect the epoxide-diol ratios. These findings suggest that epoxide-diol ratios, commonly used as indicators of sEH activity, are not influenced by substrate availability or altered plasma FFA levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kin Sing Stephen Lee, Jen C. Ng, Jun Yang, Sung-Hee Hwang, Christophe Morisseau, Karen Wagner, Bruce D. Hammock
BIOORGANIC & MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Quan Gao, Hao Jiang, Feng Tang, Hai-qun Cao, Xiang-wei Wu, Fei-fei Qi, Jia Sun, Jun Yang