Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death
出版年份 2022 全文链接
标题
Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death
作者
关键词
-
出版物
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 144, Issue 32, Pages 14706-14721
出版商
American Chemical Society (ACS)
发表日期
2022-08-04
DOI
10.1021/jacs.2c05252
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Ferroptosis: mechanisms, biology and role in disease
- (2021) Xuejun Jiang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived Peroxyl Radicals and Hydroperoxyl Radicals
- (2020) Jia-Fei Poon et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
- (2020) Mariluz Soula et al. Nature Chemical Biology
- Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture
- (2020) Michelle Riegman et al. NATURE CELL BIOLOGY
- Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease
- (2020) Jun Liu et al. ACS Medicinal Chemistry Letters
- Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model
- (2020) Wei Yang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- FSP1 is a glutathione-independent ferroptosis suppressor
- (2019) Sebastian Doll et al. NATURE
- The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
- (2019) Kirill Bersuker et al. NATURE
- The chemical basis of ferroptosis
- (2019) Marcus Conrad et al. Nature Chemical Biology
- GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
- (2019) Vanessa A. N. Kraft et al. ACS Central Science
- Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis
- (2018) Ron Shah et al. ACS Central Science
- Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration
- (2018) Shashank Masaldan et al. FREE RADICAL BIOLOGY AND MEDICINE
- Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy
- (2018) Lars Devisscher et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lipid Peroxidation: Kinetics, Mechanisms, and Products
- (2017) Zosia A. M. Zielinski et al. JOURNAL OF ORGANIC CHEMISTRY
- Phenoxazine: A Privileged Scaffold for Radical-Trapping Antioxidants
- (2017) Luke A. Farmer et al. JOURNAL OF ORGANIC CHEMISTRY
- On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death
- (2017) Omkar Zilka et al. ACS Central Science
- Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties
- (2016) Sam Hofmans et al. JOURNAL OF MEDICINAL CHEMISTRY
- Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection
- (2016) Maike J. Ohlow et al. PHARMACEUTICAL RESEARCH
- A Continuous Visible Light Spectrophotometric Approach To Accurately Determine the Reactivity of Radical-Trapping Antioxidants
- (2015) Evan A. Haidasz et al. JOURNAL OF ORGANIC CHEMISTRY
- The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in mice
- (2015) Phuriphong Songarj et al. NEUROSCIENCE LETTERS
- Advances in Radical-Trapping Antioxidant Chemistry in the 21st Century: A Kinetics and Mechanisms Perspective
- (2014) Keith U. Ingold et al. CHEMICAL REVIEWS
- Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
- (2014) Jose Pedro Friedmann Angeli et al. NATURE CELL BIOLOGY
- Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein
- (2014) Xiang Zhang et al. Applied Sciences-Basel
- Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence
- (2013) Etsuo Niki FREE RADICAL BIOLOGY AND MEDICINE
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease
- (2011) Jesper Z. Haeggström et al. CHEMICAL REVIEWS
- Free Radical Lipid Peroxidation: Mechanisms and Analysis
- (2011) Huiyong Yin et al. CHEMICAL REVIEWS
- Rate Constants for Peroxidation of Polyunsaturated Fatty Acids and Sterols in Solution and in Liposomes
- (2009) Libin Xu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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