Indole-chalcone linked 1,2,3-triazole hybrids: Facile synthesis, antimicrobial evaluation and docking studies as potential antimicrobial agents

Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells

(2021) Soha H. Emam et al.   BIOORGANIC CHEMISTRY

Design, synthesis, anticancer activity and In‐silico studies of novel imidazo[1,2‐ a ]pyridine based 1 H ‐1,2,3‐triazole derivatives

(2021) Srinivas Endoori et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis, antimalarial and antioxidant activity of coumarin appended 1,4-disubstituted 1,2,3-triazoles

(2021) C. P. Kaushik et al.   MONATSHEFTE FUR CHEMIE

Pyrazoline tethered 1,2,3-triazoles: Synthesis, antimicrobial evaluation and in silico studies

(2021) Lokesh Kumar et al.   JOURNAL OF MOLECULAR STRUCTURE

Chalcone hybrids and their antimalarial activity

(2020) Peng Cheng et al.   ARCHIV DER PHARMAZIE

The Molecular Docking, Synthesis and anti-HIV-1 protease Activity of Novel Chalcones

(2020) Nemanja Turkovic et al.   CURRENT PHARMACEUTICAL DESIGN

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities

(2020) Lin Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A multicomponent reaction to design antimalarial pyridyl-indole derivatives: Synthesis, biological activities and molecular docking

(2020) Heba A.H. Elshemy et al.   BIOORGANIC CHEMISTRY

Indole chalcones: Design, synthesis, in vitro and in silico evaluation against Mycobacterium tuberculosis

(2020) Deepthi Ramesh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, biological activity, molecular docking and computational studies on novel 1,4-disubstituted-1,2,3-Triazole-Thiosemicarbazone hybrid molecules

(2020) Naveen et al.   JOURNAL OF MOLECULAR STRUCTURE

1,2,3‐Triazole hybrids with anti‐HIV‐1 activity

(2020) Lian‐Shun Feng et al.   ARCHIV DER PHARMAZIE

Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase

(2020) Gregory S. Basarab et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization, α-glucosidase inhibition and molecular modeling studies of some pyrazoline-1H-1,2,3-triazole hybrids

(2020) Lokesh Kumar et al.   JOURNAL OF MOLECULAR STRUCTURE

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Design, synthesis, DNA binding, modeling, anticancer studies and DFT calculations of Schiff bases tethering benzothiazole-1,2,3-triazole conjugates

(2020) Meshal A. Almehmadi et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, click conventional and microwave syntheses, DNA binding, docking and anticancer studies of benzotriazole-1,2,3-triazole molecular hybrids with different pharmacophores

(2020) Shaya Yahya Alraqa et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis and evaluation of novel substituted 1,2,3-triazolyldihydroquinolines as promising antitubercular agents

(2019) Sandeep Kumar Marvadi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Piperazine-azole-fluoroquinolone hybrids: Conventional and microwave irradiated synthesis, biological activity screening and molecular docking studies

(2019) Arif Mermer et al.   BIOORGANIC CHEMISTRY

The significance of N-methylpicolinamides in the development of anticancer therapeutics: Synthesis and structure-activity relationship (SAR) studies

(2019) Balakrishna Moku et al.   BIOORGANIC CHEMISTRY

Concurrent pathway and unexpected products in the CuAAC reaction of ethyl prop-2-ynyl methylphosphonate with aromatic azides

(2019) Nazariy T. Pokhodylo et al.   Chemistry of Heterocyclic Compounds

Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents

(2019) Mona Monir Kamel et al.   Medicinal Chemistry

Synthesis and evaluation of a novel quinoline-triazole analogs for antitubercular properties via molecular hybridization approach

(2019) Jurupula Ramprasad et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Study of prototropic reactions of indole chalcone derivatives in ground and excited states using absorption and fluorescence spectroscopy

(2019) Manju K. Saroj et al.   JOURNAL OF MOLECULAR LIQUIDS

Computational investigations and molecular dynamics simulations envisioned for potent antioxidant and anticancer drugs using indole-chalcone-triazole hybrids

(2019) Sanjai Kumar Yadav et al.   DNA REPAIR

In vitro anti-malarial efficacy of chalcones: cytotoxicity profile, mechanism of action and their effect on erythrocytes

(2019) Shweta Sinha et al.   MALARIA JOURNAL

Design, synthesis, characterization, antimicrobial evaluation and molecular modeling studies of some dehydroacetic acid-chalcone-1,2,3-triazole hybrids

(2018) Kashmiri Lal et al.   BIOORGANIC CHEMISTRY

Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study

(2018) Ghandoura Moussa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Amino Acid-Derived 1,2,3-Triazoles: Development of a Nontrivial Fluorescent Sensor in Solution for the Enantioselective Sensing of a Carbohydrate and Bovine Serum Albumin Interaction

(2018) Natalí P. Debia et al.   JOURNAL OF ORGANIC CHEMISTRY

Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease

(2018) Ireen Denya et al.   MedChemComm

DNA-binding, enzyme inhibition, and photochemical properties of chalcone-containing metallophthalocyanine compounds

(2018) Furkan Özen et al.   BIOORGANIC CHEMISTRY

Oxazolone-1,2,3-triazole hybrids: Design, synthesis and antimicrobial evaluation

(2018) Kashmiri Lal et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

(2018) Chuang Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New Chalcone Derivative: Synthesis, Characterization, Computational Studies and Antioxidant Activity

(2018) Reşat Ustabaşa et al.   LETTERS IN ORGANIC CHEMISTRY

Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas

(2018) Giuseppina Sanna et al.   MOLECULES

Isatin derivatives and their anti-bacterial activities

(2018) Hua Guo   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity

(2017) Marcelo N. Gomes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiviral properties of novel indole-based thiosemicarbazides and 4-thiazolidinones

(2016) Gökçe Cihan-Üstündağ et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole–coumarin hybrids

(2016) Tatjana Gazivoda Kraljević et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An overview of molecular hybrids in drug discovery

(2016) Gervais Bérubé   Expert Opinion on Drug Discovery

An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo[3,4-b][1,4]diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents

(2015) Braulio Insuasty et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-cancer chalcones: Structural and molecular target perspectives

(2015) Debarshi Kar Mahapatra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of amino acid-linked 1,2,3-bistriazole conjugates as potential antimicrobial agents

(2013) C. P. Kaushik et al.   MEDICINAL CHEMISTRY RESEARCH

Biomedical Importance of Indoles

(2013) Nagendra Kaushik et al.   MOLECULES

New acyclic 1,2,4-triazole-based Schiff base hydrazone: Synthesis, characterization, spectrophotometric and computational studies

(2012) Hamid Khanmohammadi et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors

(2011) Horrick Sharma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Estrogenic Activity of Chemical Constituents fromTephrosia candida

(2011) Mohamed-Elamir F. Hegazy et al.   JOURNAL OF NATURAL PRODUCTS

Glycosidase inhibitory phenolic compounds from the seed of Psoralea corylifolia

(2010) Kyeong Yeol Oh et al.   FOOD CHEMISTRY

Photogeneration of reactive oxygen species and photoinduced plasmid DNA cleavage by novel synthetic chalcones

(2010) Y. Yesuthangam et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Antifungal activity of chalcones: A mechanistic study using various yeast strains

(2008) K.L. Lahtchev et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sulfonate chalcone as new class voltage-dependent K+ channel blocker

(2007) Oleg V. Yarishkin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS