Neutralizing Antibodies Against Allosteric Proteins: Insights From a Bacterial Adhesin

Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neutralization and Detection

(2021) Tomasz Slezak et al.   JOURNAL OF MOLECULAR BIOLOGY

Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core

(2021) Dagmara I. Kisiela et al.   PLoS Pathogens

In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies

(2021) Dapeng Li et al.   CELL

How Antibodies Recognize Pathogenic Viruses: Structural Correlates of Antibody Neutralization of HIV-1, SARS-CoV-2, and Zika

(2021) Morgan E. Abernathy et al.   Viruses-Basel

Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

(2021) Nikolas Friedrich et al.   Nature Communications

Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state

(2021) Jing Li et al.   eLife

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

The structural basis of herpesvirus entry

(2020) Sarah A. Connolly et al.   NATURE REVIEWS MICROBIOLOGY

Immunoglobulin-fold containing bacterial adhesins: Molecular and structural perspectives in host tissue colonization and infection

(2020) Shruti Chatterjee et al.   FEMS MICROBIOLOGY LETTERS

Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines

(2018) Felix A. Rey et al.   CELL

Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets

(2018) Olga Yakovenko et al.   INFECTION AND IMMUNITY

Protein adhesins as vaccine antigens for Group A Streptococcus

(2018) J M Raynes et al.   Pathogens and Disease

Regulatory element in fibrin triggers tension-activated transition from catch to slip bonds

(2018) Rustem I. Litvinov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn’s disease

(2017) Laurel K. Mydock-McGrane et al.   Expert Opinion on Drug Discovery

Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system

(2017) Said Rabbani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike

(2017) Gabriel Ozorowski et al.   NATURE

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions

(2017) Vasilios Kalas et al.   Science Advances

Mechanism of allosteric propagation across a β-sheet structure investigated by molecular dynamics simulations

(2016) Gianluca Interlandi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Catch-bond mechanism of the bacterial adhesin FimH

(2016) Maximilian M. Sauer et al.   Nature Communications

The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography

(2015) Brigitte Fiege et al.   CHEMBIOCHEM

FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile

(2015) Simon Kleeb et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inactive conformation enhances binding function in physiological conditions

(2015) Olga Yakovenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli

(2015) Dagmara I. Kisiela et al.   PLoS Pathogens

Study of the Structural and Dynamic Effects in the FimH Adhesin upon α-d-Heptyl Mannose Binding

(2014) Sophie Vanwetswinkel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Correction: Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH–Oligomannose-3 Complex

(2014) Adinda Wellens et al.   PLoS One

A Unified View of “How Allostery Works”

(2014) Chung-Jung Tsai et al.   PLoS Computational Biology

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn’s Disease Patients

(2013) Sami Brument et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural and energetic basis of folded-protein transport by the FimD usher

(2013) Sebastian Geibel et al.   NATURE

Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus

(2013) Timothy J. Foster et al.   NATURE REVIEWS MICROBIOLOGY

Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin

(2013) D. I. Kisiela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Validation of Reactivity Descriptors to Assess the Aromatic Stacking within the Tyrosine Gate of FimH

(2013) Goedele Roos et al.   ACS Medicinal Chemistry Letters

The Tyrosine Gate as a Potential Entropic Lever in the Receptor-Binding Site of the Bacterial Adhesin FimH

(2012) Adinda Wellens et al.   BIOCHEMISTRY

Preventing urinary tract infection: progress toward an effectiveEscherichia colivaccine

(2012) Ariel R Brumbaugh et al.   Expert Review of Vaccines

An analysis of B-cell epitope discontinuity

(2012) Ganesh N. Sivalingam et al.   MOLECULAR IMMUNOLOGY

Ideal, catch, and slip bonds in cadherin adhesion

(2012) S. Rakshit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 1 Fimbrial Adhesin FimH Elicits an Immune Response That Enhances Cell Adhesion of Escherichia coli

(2011) Veronika Tchesnokova et al.   INFECTION AND IMMUNITY

Allosteric Catch Bond Properties of the FimH Adhesin fromSalmonella entericaSerovar Typhimurium

(2011) Dagmara I. Kisiela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of agonist-induced activation in constitutively active rhodopsin

(2011) Jörg Standfuss et al.   NATURE

Accessing a Hidden Conformation of the Maltose Binding Protein Using Accelerated Molecular Dynamics

(2011) Denis Bucher et al.   PLoS Computational Biology

Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting

(2010) Isolde Le Trong et al.   CELL

Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists

(2010) Zhenfu Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

Donor strand exchange and conformational changes during E. coli fimbrial formation

(2010) Isolde Le Trong et al.   JOURNAL OF STRUCTURAL BIOLOGY

Shear-enhanced binding of intestinal colonization factor antigen I of enterotoxigenicEscherichia coli

(2010) Veronika Tchesnokova et al.   MOLECULAR MICROBIOLOGY

Shear-Enhanced Oral Microbial Adhesion

(2009) A. M. Ding et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Comparative Structure-Function Analysis of Mannose-Specific FimH Adhesins from Klebsiella pneumoniae and Escherichia coli

(2009) S. G. Stahlhut et al.   JOURNAL OF BACTERIOLOGY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

FimH Forms Catch Bonds That Are Enhanced by Mechanical Force Due to Allosteric Regulation

(2008) Olga Yakovenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin-like Allosteric Properties of the Catch Bond-forming FimH Adhesin ofEscherichia coli

(2008) Veronika Tchesnokova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY