Protein adhesins as vaccine antigens for Group A Streptococcus

Variation, Indispensability, and Masking in the M protein

(2018) Partho Ghosh   TRENDS IN MICROBIOLOGY

Development of a high-throughput opsonophagocytic assay for the determination of functional antibody activity against Streptococcus pyogenes using bioluminescence

(2017) Natalie Lorenz et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Global, Regional, and National Burden of Rheumatic Heart Disease, 1990–2015

(2017) David A. Watkins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure-based design of broadly protective group a streptococcal M protein-based vaccines

(2017) James B. Dale et al.   VACCINE

Mucosal vaccination with pili from Group A Streptococcus expressed on Lactococcus lactis generates protective immune responses

(2017) Jacelyn M. S. Loh et al.   Scientific Reports

Comparative M-protein analysis of Streptococcus pyogenes from pharyngitis and skin infections in New Zealand: Implications for vaccine development

(2016) Deborah A Williamson et al.   BMC INFECTIOUS DISEASES

Combinatorial Synthetic Peptide Vaccine Strategy Protects against Hypervirulent CovR/S Mutant Streptococci

(2016) Manisha Pandey et al.   JOURNAL OF IMMUNOLOGY

Development of a multicomponent vaccine for Streptococcus pyogenes based on the antigenic targets of IVIG

(2016) Mark Reglinski et al.   JOURNAL OF INFECTION

Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation

(2016) Mark Reglinski et al.   JOURNAL OF MICROBIOLOGICAL METHODS

The Group A Streptococcus serotype M2 pilus plays a role in host cell adhesion and immune evasion

(2016) Jia-Yun C. Tsai et al.   MOLECULAR MICROBIOLOGY

Coiled-coil destabilizing residues in the group AStreptococcusM1 protein are required for functional interaction

(2016) Chelsea M. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Status of research and development of vaccines for Streptococcus pyogenes

(2016) Andrew C. Steer et al.   VACCINE

Serological Evidence of Immune Priming by Group A Streptococci in Patients with Acute Rheumatic Fever

(2016) Jeremy M. Raynes et al.   Frontiers in Microbiology

Acute rheumatic fever and rheumatic heart disease

(2016) Jonathan R. Carapetis et al.   Nature Reviews Disease Primers

Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein

(2016) Cosmo Z. Buffalo et al.   Nature Microbiology

Predicted Coverage and Immuno-Safety of a Recombinant C-Repeat Region Based Streptococcus pyogenes Vaccine Candidate

(2016) Celia McNeilly et al.   PLoS One

Strategic development of the conserved region of the M protein and other candidates as vaccines to prevent infection with group A streptococci

(2015) Michael F Good et al.   Expert Review of Vaccines

Development of Group A streptococcal vaccines: an unmet global health need

(2015) Meru Sheel et al.   Expert Review of Vaccines

M-Protein Analysis of Streptococcus pyogenes Isolates Associated with Acute Rheumatic Fever in New Zealand

(2015) Deborah A. Williamson et al.   JOURNAL OF CLINICAL MICROBIOLOGY

An internal thioester in a pathogen surface protein mediates covalent host binding

(2015) Miriam Walden et al.   eLife

Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus

(2015) Shu Ki Tsoi et al.   Journal of Immunology Research

Sequence variability is correlated with weak immunogenicity inStreptococcus pyogenesM protein

(2015) Jonas Lannergård et al.   MicrobiologyOpen

Structural Conservation, Variability, and Immunogenicity of the T6 Backbone Pilin of Serotype M6 Streptococcus pyogenes

(2014) Paul G. Young et al.   INFECTION AND IMMUNITY

A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development

(2014) Martina Sanderson-Smith et al.   JOURNAL OF INFECTIOUS DISEASES

Survey of the bp/tee genes from clinical group A streptococcus isolates in New Zealand - implications for vaccine development

(2014) J. D. Steemson et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Working towards a Group A Streptococcal vaccine: Report of a collaborative Trans-Tasman workshop

(2014) Nicole J. Moreland et al.   VACCINE

Toxic Shock Syndrome

(2013) Donald E. Low   CRITICAL CARE CLINICS

Structural Model for Covalent Adhesion of theStreptococcus pyogenesPilus through a Thioester Bond

(2013) Christian Linke-Winnebeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential coverage of a multivalent M protein-based group A streptococcal vaccine

(2013) James B. Dale et al.   VACCINE

Factor H Binds to the Hypervariable Region of Many Streptococcus pyogenes M Proteins but Does Not Promote Phagocytosis Resistance or Acute Virulence

(2013) Mattias C. U. Gustafsson et al.   PLoS Pathogens

Pleiotropic virulence factor -Streptococcus pyogenesfibronectin-binding proteins

(2012) Masaya Yamaguchi et al.   CELLULAR MICROBIOLOGY

Anti-adhesion methods as novel therapeutics for bacterial infections

(2012) Daniel Cozens et al.   Expert Review of Anti-Infective Therapy

Incidence of acute rheumatic fever in New Zealand children and youth

(2012) Richard J Milne et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Multi High-Throughput Approach for Highly Selective Identification of Vaccine Candidates: the Group A Streptococcus Case

(2012) Giuliano Bensi et al.   MOLECULAR & CELLULAR PROTEOMICS

The ancillary protein 1 of Streptococcus pyogenes FCT-1 pili mediates cell adhesion and biofilm formation through heterophilic as well as homophilic interactions

(2012) Marco Becherelli et al.   MOLECULAR MICROBIOLOGY

The streptococcal hemoprotein receptor

(2012) Zehava Eichenbaum   Virulence

The Hypervariable Region of Streptococcus pyogenes M Protein Escapes Antibody Attack by Antigenic Variation and Weak Immunogenicity

(2011) Jonas Lannergård et al.   Cell Host & Microbe

A Novel Monoclonal Antibody against FbaA Can Inhibit the Binding of the Complement Regulatory Protein Factor H to Group A Streptococcus

(2011) Cuiqing Ma et al.   Clinical and Vaccine Immunology

Involvement of T6 Pili in Biofilm Formation by Serotype M6 Streptococcus pyogenes

(2011) K. R. Kimura et al.   JOURNAL OF BACTERIOLOGY

Structural and Functional Analysis of the Tandem β-Zipper Interaction of a Streptococcal Protein with Human Fibronectin

(2011) Nicole C. Norris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly Mechanism of FCT Region Type 1 Pili in Serotype M6Streptococcus pyogenes

(2011) Masanobu Nakata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defense From the Group A Streptococcus by Active and Passive Vaccination With the Streptococcal Hemoprotein Receptor

(2011) Ya-Shu Huang et al.   JOURNAL OF INFECTIOUS DISEASES

Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections

(2011) A. Nuccitelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New 30-valent M protein-based vaccine evokes cross-opsonic antibodies against non-vaccine serotypes of group A streptococci

(2011) James B. Dale et al.   VACCINE

Surface Export of GAPDH/SDH, a Glycolytic Enzyme, Is Essential for Streptococcus pyogenes Virulence

(2011) H. Jin et al.   mBio

Roles of Minor Pilin Subunits Spy0125 and Spy0130 in the Serotype M1 Streptococcus pyogenes Strain SF370

(2010) W. D. Smith et al.   JOURNAL OF BACTERIOLOGY

Isopeptide Bonds Block the Mechanical Extension of Pili in PathogenicStreptococcus pyogenes

(2010) Jorge Alegre-Cebollada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Highly Unusual Thioester Bond in a Pilus Adhesin Is Required for Efficient Host Cell Interaction

(2010) Jonathan A. Pointon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Minor Pilin FctB Reveals Determinants of Group A Streptococcal Pilus Anchoring

(2010) Christian Linke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rheumatic fever in Indigenous Australian children

(2010) Matthew G Parnaby et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

The streptococcal M protein: a highly versatile molecule

(2010) Pierre R. Smeesters et al.   TRENDS IN MICROBIOLOGY

Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes

(2010) Thomas A. Penfound et al.   VACCINE

Group A streptococcal vaccines: facts versus fantasy

(2009) Andrew C Steer et al.   CURRENT OPINION IN INFECTIOUS DISEASES

emm and C-Repeat Region Molecular Typing of Beta-Hemolytic Streptococci in a Tropical Country: Implications for Vaccine Development

(2009) A. C. Steer et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A vaccine against S. pyogenes: Design and experimental immune response

(2009) L. Guilherme et al.   METHODS

Crucial Role of the CB3-Region of Collagen IV in PARF-Induced Acute Rheumatic Fever

(2009) Katrin Dinkla et al.   PLoS One

Pili in Gram-negative and Gram-positive bacteria — structure, assembly and their role in disease

(2008) T. Proft et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epidemiology of Severe Streptococcus pyogenes Disease in Europe

(2008) T. L. Lamagni et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Sequence Variation in Group AStreptococcusPili and Association of Pilus Backbone Types with Lancefield T Serotypes

(2008) Fabiana Falugi et al.   JOURNAL OF INFECTIOUS DISEASES

Coiled-Coil Irregularities and Instabilities in Group A Streptococcus M1 Are Required for Virulence

(2008) C. McNamara et al.   SCIENCE

Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator

(2003) Yutaka Terao et al.   MOLECULAR MICROBIOLOGY