Complexin Membrane Interactions: Implications for Synapse Evolution and Function

The complexin C-terminal amphipathic helix stabilizes the fusion pore open state by sculpting membranes

(2022) Kevin C. Courtney et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release

(2022) Kirill Grushin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms Underlying Neurotransmitter Release

(2022) Josep Rizo   Annual Review of Biophysics

Molecular determinants of complexin clamping and activation function

(2022) Manindra Bera et al.   eLife

A crown-group cnidarian from the Ediacaran of Charnwood Forest, UK

(2022) F. S. Dunn et al.   Nature Ecology & Evolution

Choanoflagellates and the ancestry of neurosecretory vesicles

(2021) Ronja Göhde et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Assembly of the presynaptic active zone

(2020) Javier Emperador-Melero et al.   CURRENT OPINION IN NEUROBIOLOGY

Complexin Suppresses Spontaneous Exocytosis by Capturing the Membrane-Proximal Regions of VAMP2 and SNAP25

(2020) Jörg Malsam et al.   Cell Reports

The control of release probability at nerve terminals

(2019) Jeremy S. Dittman et al.   NATURE REVIEWS NEUROSCIENCE

Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release

(2019) Francisco José López-Murcia et al.   Cell Reports

Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix

(2019) Nicole Scholz et al.   JOURNAL OF CELL BIOLOGY

Nanoscale Organization of Vesicle Release at Central Synapses

(2019) Michael W. Gramlich et al.   TRENDS IN NEUROSCIENCES

Unc13: a multifunctional synaptic marvel

(2019) Jeremy S Dittman   CURRENT OPINION IN NEUROBIOLOGY

Molecular Mechanisms of Fast Neurotransmitter Release

(2018) Axel T. Brunger et al.   Annual Review of Biophysics

Mechanism of neurotransmitter release coming into focus

(2018) Josep Rizo   PROTEIN SCIENCE

A Ca 2+ Sensor for Exocytosis

(2018) Edwin R. Chapman   TRENDS IN NEUROSCIENCES

Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties

(2018) Huan Bao et al.   NATURE

A mechanism for exocytotic arrest by the Complexin C-terminus

(2018) Mazen Makke et al.   eLife

Evidence for a conserved inhibitory binding mode between the membrane fusion assembly factors Munc18 and syntaxin in animals

(2017) Czuee Morey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes

(2017) Eric A Prinslow et al.   eLife

Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function

(2017) David Snead et al.   Frontiers in Molecular Neuroscience

Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins

(2017) Rachel T. Wragg et al.   Frontiers in Molecular Neuroscience

Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion

(2016) Alexander Vasin et al.   BIOPHYSICAL JOURNAL

Functional Roles of Complexin 3 and Complexin 4 at Mouse Photoreceptor Ribbon Synapses

(2016) Norbert Babai et al.   JOURNAL OF NEUROSCIENCE

Should I stop or should I go? The role of complexin in neurotransmitter release

(2016) Thorsten Trimbuch et al.   NATURE REVIEWS NEUROSCIENCE

Mapping membrane activity in undiscovered peptide sequence space using machine learning

(2016) Ernest Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-terminal domain of mammalian complexin-1 localizes to highly curved membranes

(2016) Jihong Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal domain of complexin independently activates calcium-triggered fusion

(2016) Ying Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses

(2016) Lena S. Mortensen et al.   Cell Reports

The proteins of exocytosis: lessons from the sperm model

(2015) Claudia Nora Tomes   BIOCHEMICAL JOURNAL

Synaptic Activity Regulates the Abundance and Binding of Complexin

(2015) Rachel T. Wragg et al.   BIOPHYSICAL JOURNAL

Evolutionary conservation of complexins: from choanoflagellates to mice

(2015) X. Yang et al.   EMBO REPORTS

Complexin Stabilizes Newly Primed Synaptic Vesicles and Prevents Their Premature Fusion at the Mouse Calyx of Held Synapse

(2015) S. Chang et al.   JOURNAL OF NEUROSCIENCE

Functional Roles of Complexin in Neurotransmitter Release at Ribbon Synapses of Mouse Retinal Bipolar Neurons

(2015) T. Vaithianathan et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity

(2015) Richard W. Cho et al.   NEURON

Re-visiting the trans insertion model for complexin clamping

(2015) Shyam S Krishnakumar et al.   eLife

Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics

(2014) Madhurima Dhara et al.   JOURNAL OF CELL BIOLOGY

Origin and early diversification of the phylum Cnidaria Verrill: major developments in the analysis of the taxon's Proterozoic-Cambrian history

(2014) Heyo Van Iten et al.   PALAEONTOLOGY

Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo

(2014) R. W. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane curvature sensing by the C-terminal domain of complexin

(2014) David Snead et al.   Nature Communications

The accessory helix of complexin functions by stabilizing central helix secondary structure

(2014) Daniel T Radoff et al.   eLife

Re-examining how complexin inhibits neurotransmitter release

(2014) Thorsten Trimbuch et al.   eLife

Amphipathic Lipid Packing Sensor Motifs: Probing Bilayer Defects with Hydrophobic Residues

(2013) Stefano Vanni et al.   BIOPHYSICAL JOURNAL

Essential N-Terminal Insertion Motif Anchors the ESCRT-III Filament during MVB Vesicle Formation

(2013) Nicholas J. Buchkovich et al.   DEVELOPMENTAL CELL

Stabilization of Spontaneous Neurotransmitter Release at Ribbon Synapses by Ribbon-Specific Subtypes of Complexin

(2013) T. Vaithianathan et al.   JOURNAL OF NEUROSCIENCE

Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutant

(2013) Janani Iyer et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Synaptic Vesicles Position Complexin to Block Spontaneous Fusion

(2013) Rachel T. Wragg et al.   NEURON

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

C-Terminal Complexin Sequence Is Selectively Required for Clamping and Priming But Not for Ca2+ Triggering of Synaptic Exocytosis

(2012) Y. J. Kaeser-Woo et al.   JOURNAL OF NEUROSCIENCE

Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin

(2012) Lauren K. Buhl et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Involvement of Complexin 2 in Docking, Locking and Unlocking of Different SNARE Complexes during Sperm Capacitation and Induced Acrosomal Exocytosis

(2012) Pei-Shiue J. Tsai et al.   PLoS One

Mechanisms of Membrane Curvature Sensing

(2011) Bruno Antonny   Annual Review of Biochemistry

Complexin Maintains Vesicles in the Primed State in C. elegans

(2011) Robert J. Hobson et al.   CURRENT BIOLOGY

Complexin Has Opposite Effects on Two Modes of Synaptic Vesicle Fusion

(2011) Jesse A. Martin et al.   CURRENT BIOLOGY

Complexin cross-links prefusion SNAREs into a zigzag array

(2011) Daniel Kümmel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis

(2011) P. Burkhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complexin 2 Modulates Vesicle-associated Membrane Protein (VAMP) 2-regulated Zymogen Granule Exocytosis in Pancreatic Acini

(2010) Michelle A. Falkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of a membrane curvature–sensing motif switches function of the HOPS subunit Vps41 in membrane tethering

(2010) Margarita Cabrera et al.   JOURNAL OF CELL BIOLOGY

Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release

(2010) Richard W. Cho et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development

(2010) George Zanazzi et al.   Neural Development

A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase

(2010) Eleftherios Karanasios et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concurrent Binding of Complexin and Synaptotagmin to Liposome-Embedded SNARE Complexes†

(2009) Michael C. Chicka et al.   BIOCHEMISTRY

A role of complexin-lipid interactions in membrane fusion

(2009) Florian Seiler et al.   FEBS LETTERS

Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4

(2009) K. Reim et al.   JOURNAL OF CELL SCIENCE

Tilting the Balance between Facilitatory and Inhibitory Functions of Mammalian and Drosophila Complexins Orchestrates Synaptic Vesicle Exocytosis

(2009) Mingshan Xue et al.   NEURON

The carboxy-terminal domain of complexin I stimulates liposome fusion

(2009) Jörg Malsam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HELIQUEST: a web server to screen sequences with specific  -helical properties

(2008) R. Gautier et al.   BIOINFORMATICS

Distinct Domains of Complexins Bind SNARE Complexes and Clamp Fusionin Vitro

(2008) Claudio G. Giraudo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

For Better or for Worse: Complexins Regulate SNARE Function and Vesicle Fusion

(2008) Nils Brose   TRAFFIC