Mapping membrane activity in undiscovered peptide sequence space using machine learning

Machine learning methods in chemoinformatics

(2014) John B. O. Mitchell   Wiley Interdisciplinary Reviews-Computational Molecular Science

propy: a tool to generate various modes of Chou’s PseAAC

(2013) Dong-Sheng Cao et al.   BIOINFORMATICS

Antimicrobial peptides and induced membrane curvature: Geometry, coordination chemistry, and molecular engineering

(2013) Nathan W. Schmidt et al.   CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE

pH-dependent disruption ofEscherichia coliATCC 25922 and model membranes by the human antimicrobial peptides hepcidin 20 and 25

(2013) Giuseppantonio Maisetta et al.   FEBS Journal

Influenza Virus A M2 Protein Generates Negative Gaussian Membrane Curvature Necessary for Budding and Scission

(2013) Nathan W. Schmidt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biophysical Investigation of the Membrane-Disrupting Mechanism of the Antimicrobial and Amyloid-Like Peptide Dermaseptin S9

(2013) Lucie Caillon et al.   PLoS One

Antimicrobial Peptides Design by Evolutionary Multiobjective Optimization

(2013) Giuseppe Maccari et al.   PLoS Computational Biology

Molecular Basis for Nanoscopic Membrane Curvature Generation from Quantum Mechanical Models and Synthetic Transporter Sequences

(2012) Nathan W. Schmidt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CS-AMPPred: An Updated SVM Model for Antimicrobial Activity Prediction in Cysteine-Stabilized Peptides

(2012) William F. Porto et al.   PLoS One

Evolutionary Trade-Offs, Pareto Optimality, and the Geometry of Phenotype Space

(2012) O. Shoval et al.   SCIENCE

Critical assessment of high-throughput standalone methods for secondary structure prediction

(2011) H. Zhang et al.   BRIEFINGS IN BIOINFORMATICS

Designing antimicrobial peptides: form follows function

(2011) Christopher D. Fjell et al.   NATURE REVIEWS DRUG DISCOVERY

Connecting Peptide Physicochemical and Antimicrobial Properties by a Rational Prediction Model

(2011) Marc Torrent et al.   PLoS One

Identification of Novel Antibacterial Peptides by Chemoinformatics and Machine Learning†

(2009) Christopher D. Fjell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Use of Artificial Intelligence in the Design of Small Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs

(2008) Artem Cherkasov et al.   ACS Chemical Biology

Antimicrobial peptides and self-DNA in autoimmune skin inflammation

(2008) Michel Gilliet et al.   CURRENT OPINION IN IMMUNOLOGY

Amyloid Aggregation on Lipid Bilayers and Its Impact on Membrane Permeability

(2008) Ran Friedman et al.   JOURNAL OF MOLECULAR BIOLOGY

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

(2008) Ikhlas A. El Karim et al.   JOURNAL OF NEUROIMMUNOLOGY

Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids

(2008) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel host defense peptides and the absence of α-defensins in the bovine genome

(2008) Christopher D. Fjell et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS