Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation

Design, Molecular Docking, Synthesis, Anticancer and Anti-Hyperglycemic Assessments of Thiazolidine-2,4-diones Bearing Sulfonylthiourea Moieties as Potent VEGFR-2 Inhibitors and PPARγ Agonists

(2022) Mohamed A. Abdelgawad et al.   Pharmaceuticals

Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management

(2022) Amany Belal et al.   MOLECULES

Multi-Phase In Silico Discovery of Potential SARS-CoV-2 RNA-Dependent RNA Polymerase Inhibitors among 3009 Clinical and FDA-Approved Related Drugs

(2022) Eslam B. Elkaeed et al.   Processes

Multi-Step In Silico Discovery of Natural Drugs against COVID-19 Targeting Main Protease

(2022) Eslam B. Elkaeed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis

(2021) Nawaf A. Alsaif et al.   BIOORGANIC CHEMISTRY

Discovery of thieno[2,3-d]pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents

(2021) Souad A. El-Metwally et al.   BIOORGANIC CHEMISTRY

New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies

(2021) Hazem Elkady et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of new quinoxaline-based derivatives as anticancer agents and potent VEGFR-2 inhibitors: Design, synthesis, and in silico study

(2021) Mohammed M. Alanazi et al.   JOURNAL OF MOLECULAR STRUCTURE

Discovery of new quinazolin-4(3H)-ones as VEGFR-2 inhibitors: Design, synthesis, and anti-proliferative evaluation

(2020) Ibrahim.H. Eissa et al.   BIOORGANIC CHEMISTRY

Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors

(2020) Abdel-Ghany A. El-Helby et al.   BIOORGANIC CHEMISTRY

Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF‐7 human breast cancer cell line

(2020) Nora M. Aborehab et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents

(2019) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, synthesis, in silico ADMET profile and GABA‐A docking of novel phthalazines as potent anticonvulsants

(2019) Abdel‐Ghany A. El‐Helby et al.   ARCHIV DER PHARMAZIE

A global view of hepatocellular carcinoma: trends, risk, prevention and management

(2019) Ju Dong Yang et al.   Nature Reviews Gastroenterology & Hepatology

Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4(3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers

(2019) Hazem A. Mahdy et al.   BIOORGANIC CHEMISTRY

Functional characterization of α7 nicotinic acetylcholine and NMDA receptor signaling in SH-SY5Y neuroblastoma cells in an ERK phosphorylation assay

(2018) Mohamed R. Elnagar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies

(2018) Ahmed Sabt et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation

(2018) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches

(2018) De Kang et al.   RSC Advances

Phthalazine-1,4-dione derivatives as non-competitive AMPA receptor antagonists: design, synthesis, anticonvulsant evaluation, ADMET profile and molecular docking

(2018) Abdel-Ghany A. El-Helby et al.   MOLECULAR DIVERSITY

Vitamin E inhibits cyclosporin A-induced CTGF and TIMP-1 expression by repressing ROS-mediated activation of TGF-β/Smad signaling pathway in rat liver

(2018) Amany Balah et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

VEGFR-2 inhibitors and apoptosis inducers: synthesis and molecular design of new benzo[g]quinazolin bearing benzenesulfonamide moiety

(2017) Mostafa M. Ghorab et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors

(2015) Vera A. Machado et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors

(2014) J.- C. Soria et al.   ANNALS OF ONCOLOGY

Review of therapeutic drug monitoring of anticancer drugs part 1 – Cytotoxics

(2014) Angelo Paci et al.   EUROPEAN JOURNAL OF CANCER

iLOGP: A Simple, Robust, and Efficient Description of n-Octanol/Water Partition Coefficient for Drug Design Using the GB/SA Approach

(2014) Antoine Daina et al.   Journal of Chemical Information and Modeling

VEGFA and tumour angiogenesis

(2013) L. Claesson-Welsh et al.   JOURNAL OF INTERNAL MEDICINE

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

(2012) Christopher A. Lipinski et al.   ADVANCED DRUG DELIVERY REVIEWS

Impact of aryloxy-linked quinazolines: A novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors

(2011) Antonio Garofalo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacophore modeling and virtual screening studies for new VEGFR-2 kinase inhibitors

(2010) Kyungik Lee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Luminescent Biological Probes Derived from Ruthenium(II) Estradiol Polypyridine Complexes

(2007) Kenneth Kam-Wing Lo et al.   INORGANIC CHEMISTRY