VEGFA and tumour angiogenesis

Vascular Hyperpermeability, Angiogenesis, and Stroma Generation

(2013) J. A. Nagy et al.   Cold Spring Harbor Perspectives in Medicine

Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency

(2012) Gustaf Christoffersson et al.   ANGIOGENESIS

c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1

(2012) Francesca Anselmi et al.   ANGIOGENESIS

Axl is essential for VEGF-A-dependent activation of PI3K/Akt

(2012) Guo-Xiang Ruan et al.   EMBO JOURNAL

VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd

(2012) Zuyue Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heterogeneity among RIP-Tag2 insulinomas allows vascular endothelial growth factor-A independent tumor expansion as revealed by studies in Shb mutant mice: Implications for tumor angiogenesis

(2012) Björn Åkerblom et al.   Molecular Oncology

Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species

(2011) Youxue Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells

(2011) Jin Oshikawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Focal Adhesion Kinase Regulates Smooth Muscle Cell Recruitment to the Developing Vasculature

(2011) Zhaokang Cheng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin  v 3

(2011) S. Lakshmikanthan et al.   BLOOD

Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output

(2011) K. Ballmer-Hofer et al.   BLOOD

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

(2011) Michael C. Schmid et al.   CANCER CELL

1'-Acetoxychavicol acetate suppresses angiogenesis-mediated human prostate tumor growth by targeting VEGF-mediated Src-FAK-Rho GTPase-signaling pathway

(2011) X. Pang et al.   CARCINOGENESIS

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

VEGF increases the proliferative capacity and eNOS/NO levels of endothelial progenitor cells through the calcineurin/NFAT signalling pathway

(2011) Long Yang et al.   CELL BIOLOGY INTERNATIONAL

Focal adhesion kinase and tumour angiogenesis

(2011) Tanguy Lechertier et al.   JOURNAL OF PATHOLOGY

Growing tumor vessels: More than one way to skin a cat – Implications for angiogenesis targeted cancer therapies

(2011) Rodrigo Leite de Oliveira et al.   MOLECULAR ASPECTS OF MEDICINE

Antiangiogenic therapy, hypoxia and metastasis: risky liaisons, or not?

(2011) Katrien De Bock et al.   Nature Reviews Clinical Oncology

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

(2011) Sarah Garrido-Urbani et al.   PLoS One

Placenta Growth Factor-1 Exerts Time-Dependent Stabilization of Adherens Junctions Following VEGF-Induced Vascular Permeability

(2011) Jun Cai et al.   PLoS One

Direct Sensing of Endothelial Oxidants by Vascular Endothelial Growth Factor Receptor-2 and c-Src

(2011) Monica Lee et al.   PLoS One

Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway

(2011) Y. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage Polarization in Health and Disease

(2011) Luca Cassetta et al.   TheScientificWorldJOURNAL

Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development

(2010) Fei Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

VEGF164 differentially regulates neutrophil and T cell adhesion through ItgaL- and ItgaM-dependent mechanisms

(2010) John H. Chidlow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1

(2010) M. V. Hoang et al.   BLOOD

Conditional Deletion of the Focal Adhesion Kinase FAK Alters Remodeling of the Blood-Brain Barrier in Glioma

(2010) J. Lee et al.   CANCER RESEARCH

VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis

(2010) Anthony A. Lanahan et al.   DEVELOPMENTAL CELL

Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle: Establishment of a Vascular System Similar to That in Native Islets

(2010) G. Christoffersson et al.   DIABETES

EDF-1 contributes to the regulation of nitric oxide release in VEGF-treated human endothelial cells

(2010) Marzia Leidi et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Activation of AMP-activated Protein Kinase by Vascular Endothelial Growth Factor Mediates Endothelial Angiogenesis Independently of Nitric-oxide Synthase

(2010) Nadine Stahmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial-Rac1 Is Not Required for Tumor Angiogenesis unless αvβ3-Integrin Is Absent

(2010) Gabriela D'Amico et al.   PLoS One

The Src Homology 2 Domain-Containing Adapter Protein B (SHB) Regulates Mouse Oocyte Maturation

(2010) Gabriela Calounova et al.   PLoS One

VEGF Stimulates RCAN1.4 Expression in Endothelial Cells via a Pathway Requiring Ca2+/Calcineurin and Protein Kinase C-δ

(2010) Katherine Holmes et al.   PLoS One

Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activation

(2010) Bertha C. Elias et al.   Cell Adhesion & Migration

Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells

(2009) Eric Sulpice et al.   BIOLOGY OF THE CELL

Dysfunctional Microvasculature as a Consequence of Shb Gene Inactivation Causes Impaired Tumor Growth

(2009) N. S. Funa et al.   CANCER RESEARCH

Direct Evidence that Bevacizumab, an Anti-VEGF Antibody, Up-regulates SDF1 , CXCR4, CXCL6, and Neuropilin 1 in Tumors from Patients with Rectal Cancer

(2009) L. Xu et al.   CANCER RESEARCH

Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells

(2009) Christine Caron et al.   CELLULAR SIGNALLING

The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications

(2009) Elisabetta Dejana et al.   DEVELOPMENTAL CELL

Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis

(2009) Sofie Mellberg et al.   FASEB JOURNAL

The Regulation of Vascular Endothelial Growth Factor-induced Microvascular Permeability Requires Rac and Reactive Oxygen Species

(2009) Elizabeth Monaghan-Benson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase D-mediated Activation of IQGAP1 through Rac1 Regulates Hyperoxia-induced p47phoxTranslocation and Reactive Oxygen Species Generation in Lung Endothelial Cells

(2009) Peter V. Usatyuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VE-PTP controls blood vessel development by balancing Tie-2 activity

(2009) Mark Winderlich et al.   JOURNAL OF CELL BIOLOGY

Suppression of RhoG activity is mediated by a syndecan 4–synectin–RhoGDI1 complex and is reversed by PKCα in a Rac1 activation pathway

(2009) Arye Elfenbein et al.   JOURNAL OF CELL BIOLOGY

Impaired glucose homeostasis in Shb−/− mice

(2009) Björn Åkerblom et al.   JOURNAL OF ENDOCRINOLOGY

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

(2009) Kwan-Hyuck Baek et al.   NATURE

Cancer Stem Cells, Hypoxia and Metastasis

(2009) Richard P. Hill et al.   SEMINARS IN RADIATION ONCOLOGY

Vascular permeability, vascular hyperpermeability and angiogenesis

(2008) Janice A. Nagy et al.   ANGIOGENESIS

NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology

(2008) Randall S. Frey et al.   ANTIOXIDANTS & REDOX SIGNALING

Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system

(2008) Y TAKUWA   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization

(2008) H. Kawamura et al.   BLOOD

Phosphorylation of p130Cas initiates Rac activation and membrane ruffling

(2008) Alok Sharma et al.   BMC CELL BIOLOGY

Targeted Deletion of the Calcineurin Inhibitor DSCR1 Suppresses Tumor Growth

(2008) Sandra Ryeom et al.   CANCER CELL

Regulation of Endothelial Nitric Oxide Synthase and Postnatal Angiogenesis by Rac1

(2008) Naoki Sawada et al.   CIRCULATION RESEARCH

H-Ras Regulates Angiogenesis and Vascular Permeability by Activation of Distinct Downstream Effectors

(2008) Doinita Serban et al.   CIRCULATION RESEARCH

Adherens junctions

(2008) Noemi Rudini et al.   CURRENT BIOLOGY

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

(2008) Julie Gavard et al.   DEVELOPMENTAL CELL

An essential role for Rac1 in endothelial cell function and vascular development

(2008) Wenfu Tan et al.   FASEB JOURNAL

The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance

(2008) Paola Allavena et al.   IMMUNOLOGICAL REVIEWS

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

(2008) Astrid F. Nottebaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Global Impact of Oncogenic Src on a Phosphotyrosine Proteome

(2008) Weifeng Luo et al.   JOURNAL OF PROTEOME RESEARCH

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

(2008) Mariona Graupera et al.   NATURE

IQGAP1-Dependent Signaling Pathway Regulates Endothelial Cell Proliferation and Angiogenesis

(2008) Rosana D. Meyer et al.   PLoS One

Class 1A PI3K regulates vessel integrity during development and tumorigenesis

(2008) T. L. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead

(2007) V. W.M. van Hinsbergh et al.   CARDIOVASCULAR RESEARCH