Lipid-peptide nanocomplexes for mRNA delivery in vitro and in vivo

Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy

(2022) Jin-Qing Liu et al.   JOURNAL OF CONTROLLED RELEASE

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

(2021) Julian D. Gillmore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene editor injected into the body treats disease

(2021) Jocelyn Kaiser   SCIENCE

Efficient Colorectal Cancer Gene Therapy with IL-15 mRNA Nano-formulation

(2020) Sibei Lei et al.   MOLECULAR PHARMACEUTICS

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation

(2018) Kalina Paunovska et al.   NANO LETTERS

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts

(2018) Martin P. Stewart et al.   CHEMICAL REVIEWS

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA

(2017) Jayesh A. Kulkarni et al.   Nanomedicine-Nanotechnology Biology and Medicine

The Formation of Nanoparticles between Small Interfering RNA and Amphipathic Cell-Penetrating Peptides

(2017) Ly Pärnaste et al.   Molecular Therapy-Nucleic Acids

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery

(2016) Owen S. Fenton et al.   ADVANCED MATERIALS

PEGylation of lipoplexes: The right balance between cytotoxicity and siRNA effectiveness

(2016) Anna Lechanteur et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Stacking up CRISPR against RNAi for therapeutic gene inhibition

(2016) Dirk Haussecker   FEBS Journal

Materials for non-viral intracellular delivery of messenger RNA therapeutics

(2016) Kevin J. Kauffman et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

(2016) Matthias A. Oberli et al.   NANO LETTERS

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

(2015) Ulrich Lächelt et al.   CHEMICAL REVIEWS

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Role of liposome and peptide in the synergistic enhancement of transfection with a lipopolyplex vector

(2015) Mustafa M. Munye et al.   Scientific Reports

Lipid-based mRNA vaccine delivery systems

(2014) Patrick Midoux et al.   Expert Review of Vaccines

Intracellular delivery of nanomaterials: How to catch endosomal escape in the act

(2014) Thomas F. Martens et al.   Nano Today

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

(2014) Y. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

The Role of the Helper Lipid on the DNA Transfection Efficiency of Lipopolyplex Formulations

(2014) Zixiu Du et al.   Scientific Reports

Engineered nanoparticles interacting with cells: size matters

(2014) Li Shang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Attacking the genome: emerging siRNA nanocarriers from concept to clinic

(2012) Christopher Alabi et al.   CURRENT OPINION IN PHARMACOLOGY

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Receptor-targeted liposome-peptide nanocomplexes for siRNA delivery

(2011) Aristides D. Tagalakis et al.   BIOMATERIALS

A Simulation Study on Nanoscale Holes Generated by Gold Nanoparticles on Negative Lipid Bilayers

(2011) Jia-Qi Lin et al.   LANGMUIR

Integrin-targeted nanocomplexes for tumour specific delivery and therapy by systemic administration

(2010) Aristides D. Tagalakis et al.   BIOMATERIALS

Tumor-specific gene transfer with receptor-mediated nanocomplexes modified by polyethylene glycol shielding and endosomally cleavable lipid and peptide linkers

(2010) Stephanie M. Grosse et al.   FASEB JOURNAL

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Cholesterol and Structurally Related Molecules in Enhancing Transfection of Cationic Liposome−DNA Complexes

(2009) Alexandra Zidovska et al.   JOURNAL OF PHYSICAL CHEMISTRY B