Enzymatic Dispersion of Biofilms: An Emerging Biocatalytic Avenue to Combat Biofilm-Mediated Microbial Infections

The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine

(2022) François Le Mauff et al.   Communications Biology

Antibody-Mediated Drug Delivery

(2021) Fatma Betul Arslan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies

(2021) Laura K. Jennings et al.   Cell Reports

Implication of Surface Properties, Bacterial Motility, and Hydrodynamic Conditions on Bacterial Surface Sensing and Their Initial Adhesion

(2021) Sherry Zheng et al.   Frontiers in Bioengineering and Biotechnology

5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice

(2021) Ferdinand Sedlmayer et al.   NUCLEIC ACIDS RESEARCH

Enzyme Therapy: Current Challenges and Future Perspectives

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Staphylococcus aureus Biofilm: Morphology, Genetics, Pathogenesis and Treatment Strategies

(2021) Muhammad Idrees et al.   International Journal of Environmental Research and Public Health

Identification of a Novel Pyruvyltransferase Using 13 C Solid-State Nuclear Magnetic Resonance To Analyze Rhizobial Exopolysaccharides

(2021) Derek H. Wells et al.   JOURNAL OF BACTERIOLOGY

Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases in the Prevention of Experimental Invasive Aspergillosis

(2021) Hanna Ostapska et al.   mBio

Prevention of biofilm formation by quorum quenching

(2020) E. Paluch et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthesis and Characterization of Selenium Nanoparticles-Lysozyme Nanohybrid System with Synergistic Antibacterial Properties

(2020) Mahsa Vahdati et al.   Scientific Reports

Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation

(2020) Natalie C. Bamford et al.   Nature Communications

Beyond Risk: Bacterial Biofilms and Their Regulating Approaches

(2020) Musa Hassan Muhammad et al.   Frontiers in Microbiology

Hyaluronic Acid and Controlled Release: A Review

(2020) Ilker S. Bayer   MOLECULES

Biofilm dispersion

(2020) Kendra P. Rumbaugh et al.   NATURE REVIEWS MICROBIOLOGY

Combinatorial effects of antibiotics and enzymes against dual-species Staphylococcus aureus and Pseudomonas aeruginosa biofilms in the wound-like medium

(2020) Rima Fanaei Pirlar et al.   PLoS One

Characterization of different alginate lyases for dissolving Pseudomonas aeruginosa biofilms

(2020) Núria Blanco-Cabra et al.   Scientific Reports

Targeting Biofilms Therapy: Current Research Strategies and Development Hurdles

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Regulatory Mechanisms and Promising Applications of Quorum Sensing-Inhibiting Agents in Control of Bacterial Biofilm Formation

(2020) Lantian Zhou et al.   Frontiers in Microbiology

Combination Therapy to Treat Fungal Biofilm-Based Infections

(2020) Jana Tits et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anionic amino acids support hydrolysis of poly-β-(1,6)-N-acetylglucosamine exopolysaccharides by the biofilm dispersing glycosidase Dispersin B

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Identification of the Clostridial cellulose synthase and characterization of the cognate glycosyl hydrolase, CcsZ

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Efficient Biofilms Eradication by Enzymatic-Cocktail of Pancreatic Protease Type-I and Bacterial α-Amylase

(2020) Seung-Cheol Jee et al.   Polymers

Discovery of novel carbohydrate-active enzymes through the rational exploration of the protein sequences space

(2019) William Helbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PROTEIN CHIMERIZATION: A NEW FRONTIER FOR ENGINEERING PROTEIN THERAPEUTICS WITH IMPROVED PHARMACOKINETICS

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Classification of Clinical Isolates of Klebsiella pneumoniae Based on Their in vitro Biofilm Forming Capabilities and Elucidation of the Biofilm Matrix Chemistry With Special Reference to the Protein Content

(2019) Ashish Kumar Singh et al.   Frontiers in Microbiology

Antibiotics versus biofilm: an emerging battleground in microbial communities

(2019) Divakar Sharma et al.   Antimicrobial Resistance and Infection Control

MoS2-Modified Curcumin Nanostructures: The Novel Theranostic Hybrid Having Potent Antibacterial and Antibiofilm Activities against Multidrug-Resistant Hypervirulent Klebsiella pneumoniae

(2019) Ashish Kumar Singh et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases

(2019) François Le Mauff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix

(2019) Daniel Passos da Silva et al.   Nature Communications

Differential Recognition of Deacetylated PNAG Oligosaccharides by a Biofilm Degrading Glycosidase

(2019) Shaochi Wang et al.   ACS Chemical Biology

Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbial biofilms

(2019) Natalie C. Bamford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antimicrobial activity of Titanium dioxide and Zinc oxide nanoparticles supported in 4A zeolite and evaluation the morphological characteristic

(2019) Maryam Azizi-Lalabadi et al.   Scientific Reports

Bacterial Biofilm Eradication Agents: A Current Review

(2019) Anthony D. Verderosa et al.   Frontiers in Chemistry

Rapid microevolution of biofilm cells in response to antibiotics

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Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions

(2019) Nigare Raheem et al.   Frontiers in Microbiology

A Novel Polysaccharide Depolymerase Encoded by the Phage SH-KP152226 Confers Specific Activity Against Multidrug-Resistant Klebsiella pneumoniae via Biofilm Degradation

(2019) Yunqiang Wu et al.   Frontiers in Microbiology

Non-eluting, surface-bound enzymes disrupt surface attachment of bacteria by continuous biofilm polysaccharide degradation

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Bacterial biofilm and associated infections

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OUP accepted manuscript

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New insight into the early stages of biofilm formation

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Hydrogel delivery of lysostaphin eliminates orthopedic implant infection byStaphylococcus aureusand supports fracture healing

(2018) Christopher T. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Consequences of Biofilm Dispersal on the Host

(2018) Derek Fleming et al.   Scientific Reports

PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms

(2018) Dustin J. Little et al.   PLoS Pathogens

Antimicrobial Photodynamic Therapy to Control Clinically Relevant Biofilm Infections

(2018) Xiaoqing Hu et al.   Frontiers in Microbiology

Bioelectric Effect and Bacterial Biofilms. a Systematic Review

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Control of Biofilm Formation in Healthcare: Recent Advances Exploiting Quorum-Sensing Interference Strategies and Multidrug Efflux Pump Inhibitors

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Antibiotic resistance: a rundown of a global crisis

(2018) Bilal Aslam et al.   Infection and Drug Resistance

In Vitro Antimicrobial Efficacy of Tobramycin Against Staphylococcus aureus Biofilms in Combination With or Without DNase I and/or Dispersin B: A Preliminary Investigation

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Targeting microbial biofilms: current and prospective therapeutic strategies

(2017) Hyun Koo et al.   NATURE REVIEWS MICROBIOLOGY

Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity

(2017) Brendan D. Snarr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Psl Produced by Mucoid Pseudomonas aeruginosa Contributes to the Establishment of Biofilms and Immune Evasion

(2017) Christopher J. Jones et al.   mBio

A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics

(2017) Yun Cai et al.   Biomed Research International

Comparative study on the in vitro effects of Pseudomonas aeruginosa and seaweed alginates on human gut microbiota

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Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wounds

(2016) Derek Fleming et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Functional and structural analysis of Pichia pastoris-expressed Aspergillus niger 1,4-β-endoglucanase

(2016) Junjie Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autoinducer-2 analogs and electric fields - an antibiotic-free bacterial biofilm combination treatment

(2016) Sowmya Subramanian et al.   BIOMEDICAL MICRODEVICES

DNA Nanocages

(2016) Arun Richard Chandrasekaran et al.   CHEMISTRY OF MATERIALS

Escherichia colibiofilm: development and therapeutic strategies

(2016) G. Sharma et al.   JOURNAL OF APPLIED MICROBIOLOGY

Biofilm Exopolysaccharides of Pathogenic Fungi: Lessons from Bacteria

(2016) Donald C. Sheppard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The application of antimicrobial photodynamic therapy (aPDT) in dentistry: a critical review

(2016) E T Carrera et al.   LASER PHYSICS

Evaluation of Mannosidase and Trypsin Enzymes Effects on Biofilm Production of Pseudomonas aeruginosa Isolated from Burn Wound Infections

(2016) Maryam Banar et al.   PLoS One

Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms

(2016) P. Baker et al.   Science Advances

Impact of Azithromycin on the Quorum Sensing-Controlled Proteome of Pseudomonas aeruginosa

(2016) J. E. Swatton et al.   PLoS One

Potent Antibacterial Nanoparticles against Biofilm and Intracellular Bacteria

(2016) Haibo Mu et al.   Scientific Reports

Nanostructured Multifunctional Surface with Antireflective and Antimicrobial Characteristics

(2015) Sohee Kim et al.   ACS Applied Materials & Interfaces

Biofilm, pathogenesis and prevention—a journey to break the wall: a review

(2015) Priya Gupta et al.   ARCHIVES OF MICROBIOLOGY

Biofilms and human health

(2015) Shilpi Srivastava et al.   BIOTECHNOLOGY LETTERS

PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix

(2015) Shan Yu et al.   CELL RESEARCH

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

Extracellular DNA as a target for biofilm control

(2015) Mira Okshevsky et al.   CURRENT OPINION IN BIOTECHNOLOGY

Chimeric Fusion Proteins Used for Therapy: Indications, Mechanisms, and Safety

(2015) Brian A. Baldo   DRUG SAFETY

Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan inAspergillus fumigatus

(2015) Natalie C. Bamford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of thePseudomonas aeruginosaGlycoside Hydrolase PslG Reveals That Its Levels Are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation

(2015) Perrin Baker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reaction Mechanisms in Carbohydrate-Active Enzymes: Glycoside Hydrolases and Glycosyltransferases. Insights from ab Initio Quantum Mechanics/Molecular Mechanics Dynamic Simulations

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L isteria monocytogenes exopolysaccharide: origin, structure, biosynthetic machinery and c-di-GMP-dependent regulation

(2015) Volkan K. Köseoğlu et al.   MOLECULAR MICROBIOLOGY

Pel is a cationic exopolysaccharide that cross-links extracellular DNA in thePseudomonas aeruginosabiofilm matrix

(2015) Laura K. Jennings et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polysaccharide intercellular adhesin in biofilm: structural and regulatory aspects

(2015) Carla Renata Arciola et al.   Frontiers in Cellular and Infection Microbiology

Enzymatic modifications of exopolysaccharides enhance bacterial persistence

(2015) Gregory B. Whitfield et al.   Frontiers in Microbiology

Effects of 5-Fluorouracil on Morphology, Cell Cycle, Proliferation, Apoptosis, Autophagy and ROS Production in Endothelial Cells and Cardiomyocytes

(2015) Chiara Focaccetti et al.   PLoS One

Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interface

(2015) Manoranjan Arakha et al.   Scientific Reports

Exploring early steps in biofilm formation: set-up of an experimental system for molecular studies

(2014) Marc Crouzet et al.   BMC MICROBIOLOGY

Antibiofilm and Antimicrobial Efficacy of DispersinB®-KSL-W Peptide-Based Wound Gel Against Chronic Wound Infection Associated Bacteria

(2014) Purushottam V. Gawande et al.   CURRENT MICROBIOLOGY

Quorum Quenching Agents: Resources for Antivirulence Therapy

(2014) Kaihao Tang et al.   Marine Drugs

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

(2014) D. Lebeaux et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing

(2014) Christopher G Pierce et al.   Nature Protocols

Biophysical Model of Bacterial Cell Interactions with Nanopatterned Cicada Wing Surfaces

(2013) Sergey Pogodin et al.   BIOPHYSICAL JOURNAL

Antimicrobial enzymes: An emerging strategy to fight microbes and microbial biofilms

(2013) Barbara Thallinger et al.   Biotechnology Journal

Efficacy and Safety of Concurrent Collagenase Clostridium Histolyticum Injections for Multiple Dupuytren Contractures

(2013) Stephen Coleman et al.   JOURNAL OF HAND SURGERY-AMERICAN VOLUME

Small molecules are natural triggers for the disassembly of biofilms

(2013) Yaara Oppenheimer-Shaanan et al.   TRENDS IN MICROBIOLOGY

Aspergillus Galactosaminogalactan Mediates Adherence to Host Constituents and Conceals Hyphal β-Glucan from the Immune System

(2013) Fabrice N. Gravelat et al.   PLoS Pathogens

Microbial alginate production, modification and its applications

(2013) Iain D. Hay et al.   Microbial Biotechnology

Immobilized antibiotics to prevent orthopaedic implant infections

(2012) Noreen J. Hickok et al.   ADVANCED DRUG DELIVERY REVIEWS

Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal

(2012) Svitlana Chernousova et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alginate Lyase Exhibits Catalysis-Independent Biofilm Dispersion and Antibiotic Synergy

(2012) John W. Lamppa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiofilm Activity of α-Amylase from Bacillus subtilis S8-18 Against Biofilm Forming Human Bacterial Pathogens

(2012) Balu Jancy Kalpana et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

An extracellular Staphylococcus epidermidis polysaccharide: relation to Polysaccharide Intercellular Adhesin and its implication in phagocytosis

(2012) Anastasia I Spiliopoulou et al.   BMC MICROBIOLOGY

Model for β-1,6-N-acetylglucosamine oligomer hydrolysis catalysed by DispersinB, a biofilm degrading enzyme

(2012) Erika Fazekas et al.   CARBOHYDRATE RESEARCH

Characteristics of bacterial biofilm associated with implant material in clinical practice

(2012) Venkatesan Nandakumar et al.   POLYMER JOURNAL

Quorum sensing: How bacteria can coordinate activity and synchronize their response to external signals?

(2012) Zhi Li et al.   PROTEIN SCIENCE

Characterization of the Poly-β-1,6-N-Acetylglucosamine Polysaccharide Component of Burkholderia Biofilms

(2011) Nandadeva Yakandawala et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Role of Exopolysaccharides in Pseudomonas aeruginosa Biofilm Formation and Architecture

(2011) Aamir Ghafoor et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Surface acoustic waves increase the susceptibility ofPseudomonas aeruginosabiofilms to antibiotic treatment

(2011) Moran Kopel et al.   BIOFOULING

Antimicrobial Peptides: Successes, Challenges and Unanswered Questions

(2011) William C. Wimley et al.   JOURNAL OF MEMBRANE BIOLOGY

Effect of Superhydrophobic Surface of Titanium onStaphylococcus aureusAdhesion

(2011) Peifu Tang et al.   Journal of Nanomaterials

Metagenomic Discovery of Biomass-Degrading Genes and Genomes from Cow Rumen

(2011) M. Hess et al.   SCIENCE

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Pancreatic enzyme replacement therapy in chronic pancreatitis

(2010) E.C.M. Sikkens et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Candida albicans biofilm formation on peptide functionalized polydimethylsiloxane

(2010) Kristof De Prijck et al.   BIOFOULING

Glycoside hydrolases: Catalytic base/nucleophile diversity

(2010) Thu V. Vuong et al.   BIOTECHNOLOGY AND BIOENGINEERING

PEGylation of therapeutic proteins

(2010) Simona Jevševar et al.   Biotechnology Journal

Anti-infective external coating of central venous catheters: A randomized, noninferiority trial comparing 5-fluorouracil with chlorhexidine/silver sulfadiazine in preventing catheter colonization*

(2010) J. Matthias Walz et al.   CRITICAL CARE MEDICINE

Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses

(2010) J.B. Kaplan   JOURNAL OF DENTAL RESEARCH

Prevention of Candida albicans Biofilm Formation by Covalently Bound Dimethylaminoethylmethacrylate and Polyethylenimine

(2010) Kristof De Prijck et al.   MYCOPATHOLOGIA

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Garlic as an inhibitor ofPseudomonas aeruginosaquorum sensing in cystic fibrosis-a pilot randomized controlled trial

(2010) Alan R. Smyth et al.   PEDIATRIC PULMONOLOGY

Structure and Kinetic Investigation of Streptococcus pyogenes Family GH38 α-Mannosidase

(2010) Michael D. L. Suits et al.   PLoS One

Cyclodextrin-functionalized biomaterials loaded with miconazole prevent Candida albicans biofilm formation in vitro

(2009) Cesar A.B. Nava-Ortiz et al.   Acta Biomaterialia

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(2009) Holger Rohde et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Properties of different pancreatin preparations used in pancreatic exocrine insufficiency

(2009) Johannes-Matthias Löhr et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Importance of DNase and alginate lyase for enhancing free and liposome encapsulated aminoglycoside activity against Pseudomonas aeruginosa

(2009) M. Alipour et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms

(2009) E. Karatan et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Bacterial Extracellular Polysaccharides Involved in Biofilm Formation

(2009) Barbara Vu et al.   MOLECULES

Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

(2009) Jemy A Gutierrez et al.   Nature Chemical Biology

Microbial Growth Inhibition by Alternating Electric Fields

(2008) M. Giladi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biofilm Formation byPneumocystisspp.

(2008) Melanie T. Cushion et al.   EUKARYOTIC CELL

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY