The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin

On the roles of the Drosophila KASH domain proteins Msp-300 and Klarsicht

(2014) Xuanhua Xie et al.   FLY

The Drosophila KASH domain proteins Msp-300 and Klarsicht and the SUN domain protein Klaroid have no essential function during oogenesis

(2014) Martin Technau et al.   FLY

LINC complexes in health and disease

(2014) Alexandre Méjat   Nucleus

The LINC complex is essential for hearing

(2013) Henning F. Horn et al.   JOURNAL OF CLINICAL INVESTIGATION

The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction

(2013) Allison B. Chambliss et al.   Scientific Reports

LINCing complex functions at the nuclear envelope

(2013) Andrea Rothballer et al.   Nucleus

Role of nesprin-1 in nuclear deformation in endothelial cells under static and uniaxial stretching conditions

(2012) Toshiro Anno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins

(2012) Brian A. Sosa et al.   CELL

Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in Progeric and Dystrophic Laminopathies

(2012) Chia-Yen Chen et al.   CELL

Interkinetic nuclear migration: beyond a hallmark of neurogenesis

(2012) Yoichi Kosodo   CELLULAR AND MOLECULAR LIFE SCIENCES

Localized Products of futile cycle/ lrmp Promote Centrosome-Nucleus Attachment in the Zebrafish Zygote

(2012) Robin E. Lindeman et al.   CURRENT BIOLOGY

Inner Nuclear Envelope Proteins SUN1 and SUN2 Play a Prominent Role in the DNA Damage Response

(2012) Kai Lei et al.   CURRENT BIOLOGY

Interkinetic nuclear migration: A mysterious process in search of a function

(2012) Philip C. Spear et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Physical Links Between the Nuclear Envelope Protein Mps3, Three Alternate Replication Factor C Complexes, and a Variant Histone in Saccharomyces cerevisiae

(2012) Jared Haas et al.   DNA AND CELL BIOLOGY

Novel plant SUN–KASH bridges are involved in RanGAP anchoring and nuclear shape determination

(2012) Xiao Zhou et al.   JOURNAL OF CELL BIOLOGY

Csi1 links centromeres to the nuclear envelope for centromere clustering

(2012) Haitong Hou et al.   JOURNAL OF CELL BIOLOGY

Organelle positioning in muscles requires cooperation between two KASH proteins and microtubules

(2012) Hadas Elhanany-Tamir et al.   JOURNAL OF CELL BIOLOGY

A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis

(2012) Akihiro Morimoto et al.   JOURNAL OF CELL BIOLOGY

Shaping the nucleus: Factors and forces

(2012) Alison D. Walters et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TFIIIC localizes budding yeast ETC sites to the nuclear periphery

(2012) Shin-ichiro Hiraga et al.   MOLECULAR BIOLOGY OF THE CELL

LINC Complexes Mediate the Positioning of Cone Photoreceptor Nuclei in Mouse Retina

(2012) David Razafsky et al.   PLoS One

The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing

(2012) R.N. Rashmi et al.   Nucleus

Nuclear envelope insertion of spindle pole bodies and nuclear pore complexes

(2012) Sue L. Jaspersen et al.   Nucleus

UnLINCing the nuclear envelope: towards an understanding of the physiological significance of nuclear positioning

(2011) David Razafsky et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of nesprins as multifunctional organizers in the nucleus and the cytoskeleton: Figure 1

(2011) Angelika A. Noegel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The LINC complex and human disease

(2011) Peter Meinke et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Opening the DNA repair toolbox: Localization of DNA double strand breaks to the nuclear periphery

(2011) Pranav Oza et al.   CELL CYCLE

Interkinetic Nuclear Migration Is a Broadly Conserved Feature of Cell Division in Pseudostratified Epithelia

(2011) Emily J. Meyer et al.   CURRENT BIOLOGY

Orientation and function of the nuclear–centrosomal axis during cell migration

(2011) GW Gant Luxton et al.   CURRENT OPINION IN CELL BIOLOGY

Polo Kinases Establish Links between Meiotic Chromosomes and Cytoskeletal Forces Essential for Homolog Pairing

(2011) Sara Labella et al.   DEVELOPMENTAL CELL

Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres

(2011) Chihiro Horigome et al.   EMBO JOURNAL

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting of the SUN protein Mps3 to the inner nuclear membrane by the histone variant H2A.Z

(2011) Jennifer M. Gardner et al.   JOURNAL OF CELL BIOLOGY

Nesprin-3 augments peripheral nuclear localization of intermediate filaments in zebrafish

(2011) R. Postel et al.   JOURNAL OF CELL SCIENCE

Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization

(2011) Joshua T. Morgan et al.   MOLECULAR BIOLOGY OF THE CELL

The SUN Protein Mps3 Is Required for Spindle Pole Body Insertion into the Nuclear Membrane and Nuclear Envelope Homeostasis

(2011) Jennifer M. Friederichs et al.   PLoS Genetics

TAN lines

(2011) G.W. Gant Luxton et al.   Nucleus

Interactions Between Nuclei and the Cytoskeleton Are Mediated by SUN-KASH Nuclear-Envelope Bridges

(2010) Daniel A. Starr et al.   Annual Review of Cell and Developmental Biology

Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope

(2010) Maria Schneider et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nesprins LINC the nucleus and cytoskeleton

(2010) Jason A Mellad et al.   CURRENT OPINION IN CELL BIOLOGY

KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development

(2010) Juehua Yu et al.   HUMAN MOLECULAR GENETICS

Nesprin-2 Interacts with α-Catenin and Regulates Wnt Signaling at the Nuclear Envelope

(2010) Sascha Neumann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus

(2010) M. P. Kracklauer et al.   JOURNAL OF CELL SCIENCE

The nuclear envelope in genome organization, expression and stability

(2010) Karim Mekhail et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammalian Sperm Head Formation Involves Different Polarization of Two Novel LINC Complexes

(2010) Eva Göb et al.   PLoS One

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Diseases of the Nuclear Envelope

(2010) H. J. Worman et al.   Cold Spring Harbor Perspectives in Biology

Role of the nuclear envelope in genome organization and gene expression

(2010) David W. Van de Vosse et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Meiotic Chromosome Homology Search Involves Modifications of the Nuclear Envelope Protein Matefin/SUN-1

(2009) Alexandra M. Penkner et al.   CELL

Cytoskeletal Forces Span the Nuclear Envelope to Coordinate Meiotic Chromosome Pairing and Synapsis

(2009) Aya Sato et al.   CELL

SUN-domain and KASH-domain proteins during development, meiosis and disease

(2009) A. Fridkin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The nuclear envelope—a scaffold for silencing?

(2009) Benjamin D Towbin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration

(2009) M. Meyerzon et al.   DEVELOPMENT

Centrosome attachment to the C. elegans male pronucleus is dependent on the surface area of the nuclear envelope

(2009) Marina Meyerzon et al.   DEVELOPMENTAL BIOLOGY

UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration

(2009) Heidi N. Fridolfsson et al.   DEVELOPMENTAL BIOLOGY

Nuclei Take a Position: Managing Nuclear Location

(2009) Brian Burke et al.   DEVELOPMENTAL CELL

The SUN Rises on Meiotic Chromosome Dynamics

(2009) Yasushi Hiraoka et al.   DEVELOPMENTAL CELL

Life on the edge: telomeres and persistent DNA breaks converge at the nuclear periphery

(2009) M. R. Gartenberg   GENES & DEVELOPMENT

Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination

(2009) H. Schober et al.   GENES & DEVELOPMENT

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

(2009) P. Oza et al.   GENES & DEVELOPMENT

Nesprin 1 is critical for nuclear positioning and anchorage

(2009) Jianlin Zhang et al.   HUMAN MOLECULAR GENETICS

Novel Nuclear Nesprin-2 Variants Tether Active Extracellular Signal-regulated MAPK1 and MAPK2 at Promyelocytic Leukemia Protein Nuclear Bodies and Act to Regulate Smooth Muscle Cell Proliferation

(2009) Derek T. Warren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation

(2009) Yuji Chikashige et al.   JOURNAL OF CELL BIOLOGY

Lamin A/C–mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy

(2009) Alexandre Méjat et al.   JOURNAL OF CELL BIOLOGY

Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections

(2009) David Razafsky et al.   JOURNAL OF CELL BIOLOGY

KDP-1 is a nuclear envelope KASH protein required for cell-cycle progression

(2009) M. D. McGee et al.   JOURNAL OF CELL SCIENCE

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton

(2009) H. R. Dawe et al.   JOURNAL OF CELL SCIENCE

SUN1/2 and Syne/Nesprin-1/2 Complexes Connect Centrosome to the Nucleus during Neurogenesis and Neuronal Migration in Mice

(2009) Xiaochang Zhang et al.   NEURON

Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

(2009) K. J. Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice

(2009) K. Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Network of Nuclear Envelope Membrane Proteins Linking Centromeres to Microtubules

(2008) Megan C. King et al.   CELL

Meiotic Chromosomes Move by Linkage to Dynamic Actin Cables with Transduction of Force through the Nuclear Envelope

(2008) R. Koszul et al.   CELL

Rapid Telomere Movement in Meiotic Prophase Is Promoted By NDJ1, MPS3, and CSM4 and Is Modulated by Recombination

(2008) Michael N. Conrad et al.   CELL

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness

(2008) P.J. Stewart-Hutchinson et al.   EXPERIMENTAL CELL RESEARCH

Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin

(2008) Y. Luke et al.   JOURNAL OF CELL SCIENCE

Csm4, in Collaboration with Ndj1, Mediates Telomere-Led Chromosome Dynamics and Recombination during Yeast Meiosis

(2008) Jennifer J. Wanat et al.   PLoS Genetics

Csm4-Dependent Telomere Movement on Nuclear Envelope Promotes Meiotic Recombination

(2008) Hiromichi Kosaka et al.   PLoS Genetics

Nuclear migration during retinal development

(2007) Lisa M. Baye et al.   BRAIN RESEARCH