Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection

Kinetic Characterization of the Immune Response to Methicillin-Resistant Staphylococcus aureus Subcutaneous Skin Infection

(2022) Miranda J. Ridder et al.   INFECTION AND IMMUNITY

Bacteria induce skin regeneration via IL-1β signaling

(2021) Gaofeng Wang et al.   Cell Host & Microbe

Interaction between Staphylococcus Agr virulence and neutrophils regulates pathogen expansion in the skin

(2021) Masanori Matsumoto et al.   Cell Host & Microbe

Specific β-defensins stimulate pruritus through activation of sensory neurons

(2021) Pang-Yen Tseng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Differential Early in vivo Dynamics and Functionality of Recruited Polymorphonuclear Neutrophils After Infection by Planktonic or Biofilm Staphylococcus aureus

(2021) Aizat Iman Abdul Hamid et al.   Frontiers in Microbiology

Structure, function and pharmacology of human itch GPCRs

(2021) Can Cao et al.   NATURE

Structure, function and pharmacology of human itch receptor complexes

(2021) Fan Yang et al.   NATURE

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

(2020) Mathias Uhlen et al.   SCIENCE

Antimicrobial peptides: Application informed by evolution

(2020) Brian P. Lazzaro et al.   SCIENCE

Functional Insights From the Evolutionary Diversification of Big Defensins

(2020) Marco Gerdol et al.   Frontiers in Immunology

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

(2020) Xuemei Xie et al.   NATURE IMMUNOLOGY

Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes

(2020) Céline Chessa et al.   Frontiers in Microbiology

Co-option of Neutrophil Fates by Tissue Environments

(2020) Iván Ballesteros et al.   CELL

MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

(2019) Mohammad Arifuzzaman et al.   Science Advances

Alterations of the Mice Gut Microbiome via Schistosoma japonicum Ova-Induced Granuloma

(2019) Yanqing Zhao et al.   Frontiers in Microbiology

PRECOG: PREdicting COupling probabilities of G-protein coupled receptors

(2019) Gurdeep Singh et al.   NUCLEIC ACIDS RESEARCH

Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines

(2019) Marco Antonio Cassatella et al.   TRENDS IN IMMUNOLOGY

Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

(2019) Mark Austin Hanson et al.   eLife

A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity

(2019) Priyanka Pundir et al.   Cell Host & Microbe

GPRC5b Modulates Inflammatory Response in Glomerular Diseases via NF-κB Pathway

(2019) Sonia Zambrano et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

(2019) Evan Bolyen et al.   NATURE BIOTECHNOLOGY

Neutrophils in Psoriasis

(2019) Chih-Chao Chiang et al.   Frontiers in Immunology

Neutrophils Enhance Their Own Influx to Sites of Bacterial Infection via Endosomal TLR-Dependent Cxcl2 Production

(2019) Germana Lentini et al.   JOURNAL OF IMMUNOLOGY

Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection

(2018) Carly A. Dillen et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophils and Bacterial Immune Evasion

(2018) Scott D. Kobayashi et al.   Journal of Innate Immunity

The human skin microbiome

(2018) Allyson L. Byrd et al.   NATURE REVIEWS MICROBIOLOGY

Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1α release

(2018) Nathan K. Archer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Alarmins and immunity

(2017) De Yang et al.   IMMUNOLOGICAL REVIEWS

Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year

(2017) Elizabeth A. Kennedy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human Skin Is the Largest Epithelial Surface for Interaction with Microbes

(2017) Richard L. Gallo   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy

(2017) Patrick Meylan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Evidence that Human Skin Microbiome Dysbiosis Promotes Atopic Dermatitis

(2017) Michael R. Williams et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cutaneous Nod2 Expression Regulates the Skin Microbiome and Wound Healing in a Murine Model

(2017) Helen Williams et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis

(2017) Teruaki Nakatsuji et al.   Science Translational Medicine

Multiple Phenotypic Changes Define Neutrophil Priming

(2017) Irina Miralda et al.   Frontiers in Cellular and Infection Microbiology

IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin

(2016) Nidhi Malhotra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression profiling of constitutive mast cells reveals a unique identity within the immune system

(2016) Daniel F Dwyer et al.   NATURE IMMUNOLOGY

Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis

(2015) Tetsuro Kobayashi et al.   IMMUNITY

Colonization of Epidermal Tissue by Staphylococcus aureus Produces Localized Hypoxia and Stimulates Secretion of Antioxidant and Caspase-14 Proteins

(2015) Abdul G. Lone et al.   INFECTION AND IMMUNITY

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

(2015) Shruti Naik et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The role of tissue resident cells in neutrophil recruitment

(2015) Nancy D. Kim et al.   TRENDS IN IMMUNOLOGY

Masking of β(1-3)-Glucan in the Cell Wall of Candida albicans from Detection by Innate Immune Cells Depends on Phosphatidylserine

(2014) Sarah E. Davis et al.   INFECTION AND IMMUNITY

Neutrophil Chemokines KC and Macrophage-Inflammatory Protein-2 Are Newly Synthesized by Tissue Macrophages Using Distinct TLR Signaling Pathways

(2014) K. De Filippo et al.   JOURNAL OF IMMUNOLOGY

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

(2014) Benjamin D. McNeil et al.   NATURE

Gene Expression during the Generation and Activation of Mouse Neutrophils: Implication of Novel Functional and Regulatory Pathways

(2014) Jeffrey A. Ericson et al.   PLoS One

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform

(2013) James J. Kozich et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation

(2013) K. De Filippo et al.   BLOOD

Intraluminal Containment of Commensal Outgrowth in the Gut during Infection-Induced Dysbiosis

(2013) Michael J. Molloy et al.   Cell Host & Microbe

 -Defensins Activate Human Mast Cells via Mas-Related Gene X2

(2013) H. Subramanian et al.   JOURNAL OF IMMUNOLOGY

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

RNA-Seq Reveals Activation of Both Common and Cytokine-Specific Pathways following Neutrophil Priming

(2013) Helen L. Wright et al.   PLoS One

Staphylococcus aureus Alpha Toxin Suppresses Effective Innate and Adaptive Immune Responses in a Murine Dermonecrosis Model

(2013) Christine Tkaczyk et al.   PLoS One

Partial Deletion of Chromosome 8 β-defensin Cluster Confers Sperm Dysfunction and Infertility in Male Mice

(2013) Yu S. Zhou et al.   PLoS Genetics

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Compartmentalized Control of Skin Immunity by Resident Commensals

(2012) S. Naik et al.   SCIENCE

Neutrophil-derived IL-1β Is Sufficient for Abscess Formation in Immunity against Staphylococcus aureus in Mice

(2012) John S. Cho et al.   PLoS Pathogens

Host–pathogen interactions between the skin and Staphylococcus aureus

(2011) Sheila Krishna et al.   CURRENT OPINION IN MICROBIOLOGY

Induction of Regulatory T Cells by a Murine  -Defensin

(2011) F. Navid et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial Peptides: Old Molecules with New Ideas

(2011) Teruaki Nakatsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

The skin microbiome

(2011) Elizabeth A. Grice et al.   NATURE REVIEWS MICROBIOLOGY

Neutrophils cascading their way to inflammation

(2011) Christian D. Sadik et al.   TRENDS IN IMMUNOLOGY

Lipid-Cytokine-Chemokine Cascade Drives Neutrophil Recruitment in a Murine Model of Inflammatory Arthritis

(2010) Richard C. Chou et al.   IMMUNITY

Human  -Defensin 2 and 3 and Their Mouse Orthologs Induce Chemotaxis through Interaction with CCR2

(2010) J. Rohrl et al.   JOURNAL OF IMMUNOLOGY

Mechanical and Metabolic Injury to the Skin Barrier Leads to Increased Expression of Murine β-Defensin-1, -3, and -14

(2010) Kerstin Ahrens et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome

(2009) Clara Amid et al.   BMC GENOMICS

Topographical and Temporal Diversity of the Human Skin Microbiome

(2009) E. A. Grice et al.   SCIENCE

Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3

(2008) K. Hinrichsen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

(2008) Brian D. Corbin et al.   SCIENCE