Circadian modulation of microglial physiological processes and immune responses

Suprachiasmatic nucleus-mediated glucose entry into the arcuate nucleus determines the daily rhythm in blood glycemia

(2022) Betty Rodríguez-Cortés et al.   CURRENT BIOLOGY

The circadian immune system

(2022) Chen Wang et al.   Science Immunology

Single-cell RNA-seq analysis reveals compartment-specific heterogeneity and plasticity of microglia

(2021) Junying Zheng et al.   iScience

Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle

(2021) Giorgio Corsi et al.   GLIA

Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity

(2021) Xiao-Lan Wang et al.   MOLECULAR PSYCHIATRY

Microglia sense neuronal activity via GABA in the early postnatal hippocampus

(2021) Francesca Logiacco et al.   Cell Reports

Astrocytic Modulation of Neuronal Activity in the Suprachiasmatic Nucleus: Insights from Mathematical Modeling

(2020) Natthapong Sueviriyapan et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Role of dietary fatty acids in microglial polarization in Alzheimer’s disease

(2020) Smita Eknath Desale et al.   Journal of Neuroinflammation

Microglial metabolic flexibility supports immune surveillance of the brain parenchyma

(2020) Louis-Philippe Bernier et al.   Nature Communications

Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response

(2020) Clotilde Lauro et al.   Frontiers in Immunology

Diurnal Variation Induces Neurobehavioral and Neuropathological Differences in a Rat Model of Traumatic Brain Injury

(2020) Ricardo Jesus Martinez-Tapia et al.   Frontiers in Neuroscience

Microglial ablation in rats disrupts the circadian system

(2020) Luba Sominsky et al.   FASEB JOURNAL

Clock Genes, Inflammation and the Immune System—Implications for Diabetes, Obesity and Neurodegenerative Diseases

(2020) Elaine Vieira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

(2020) Mario Merlini et al.   NATURE NEUROSCIENCE

Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism

(2020) Xiao-Lan Wang et al.   Frontiers in Immunology

Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation

(2019) Cheng-Fang Hsieh et al.   Scientific Reports

Circadian clock protein Rev-erbα regulates neuroinflammation

(2019) Percy Griffin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

The suprachiasmatic nucleus; a responsive clock regulating homeostasis by daily changing the setpoints of physiological parameters

(2019) Ruud M. Buijs et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses

(2019) Zsuzsanna Winkler et al.   Scientific Reports

Diet-Induced Obesity Disturbs Microglial Immunometabolism in a Time-of-Day Manner

(2019) Irina V. Milanova et al.   Frontiers in Endocrinology

Phagocytic elimination of synapses by microglia during sleep

(2019) Mohammed E. Choudhury et al.   GLIA

Circadian Clock Genes and the Transcriptional Architecture of the Clock Mechanism

(2019) Kimberly H. Cox et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

(2019) Junjun Ni et al.   Journal of Neuroinflammation

Insulin Regulates GABAA Receptor-Mediated Tonic Currents in the Prefrontal Cortex

(2018) Saraí Trujeque-Ramos et al.   Frontiers in Neuroscience

Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase

(2018) Yuanqing Gao et al.   Molecular Metabolism

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

(2018) James O. Early et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial modulators reduce respiratory rhythm long-term facilitation in vitro

(2018) Neira Polet Camacho-Hernández et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Conditional microglial depletion in rats leads to reversible anorexia and weight loss by disrupting gustatory circuitry

(2018) Simone N. De Luca et al.   BRAIN BEHAVIOR AND IMMUNITY

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Regulation of Hippocampal Synaptic Function by the Metabolic Hormone, Leptin: Implications for Health and Neurodegenerative Disease

(2018) Gemma McGregor et al.   Frontiers in Cellular Neuroscience

Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling

(2017) Marco Brancaccio et al.   NEURON

Ultrastructural evidence for synaptic scaling across the wake/sleep cycle

(2017) Luisa de Vivo et al.   SCIENCE

Synaptic scaling in sleep

(2017) László Acsády et al.   SCIENCE

Homer1a drives homeostatic scaling-down of excitatory synapses during sleep

(2017) Graham H. Diering et al.   SCIENCE

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus

(2017) Filippo Weisz et al.   SYNAPSE

TNFα drives mitochondrial stress in POMC neurons in obesity

(2017) Chun-Xia Yi et al.   Nature Communications

Microglia: Phagocytosing to Clear, Sculpt, and Eliminate

(2016) Soyon Hong et al.   DEVELOPMENTAL CELL

The intrinsic microglial clock system regulates interleukin-6 expression

(2016) Ryota Nakazato et al.   GLIA

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization

(2016) Laura K. Fonken et al.   NEUROBIOLOGY OF AGING

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-induced neuroinflammatory priming is time of day dependent

(2016) Laura K. Fonken et al.   PSYCHONEUROENDOCRINOLOGY

Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis

(2016) Sungho Jin et al.   Scientific Reports

Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y6 receptor system

(2016) Fumiko Takayama et al.   Scientific Reports

Microglia inflammatory responses are controlled by an intrinsic circadian clock

(2015) Laura K. Fonken et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome

(2015) M. D. Weber et al.   JOURNAL OF NEUROSCIENCE

Circadian rhythms – from genes to physiology and disease

(2015) T Bollinger et al.   SWISS MEDICAL WEEKLY

Main and accessory olfactory bulbs and their projections in the brain anticipate feeding in food-entrained rats

(2014) Mario Caba et al.   CHRONOBIOLOGY INTERNATIONAL

Adrenal Clocks and the Role of Adrenal Hormones in the Regulation of Circadian Physiology

(2014) Alexei Leliavski et al.   JOURNAL OF BIOLOGICAL RHYTHMS

The neuroanatomical function of leptin in the hypothalamus

(2014) M.M.H. van Swieten et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

(2014) Rosa Chiara Paolicelli et al.   Frontiers in Cellular Neuroscience

Circadian control of glucose metabolism

(2014) Andries Kalsbeek et al.   Molecular Metabolism

Crosstalk between the circadian clock circuitry and the immune system

(2013) Nicolas Cermakian et al.   CHRONOBIOLOGY INTERNATIONAL

A Circadian Clock Gene, Rev-erb , Modulates the Inflammatory Function of Macrophages through the Negative Regulation of Ccl2 Expression

(2013) S. Sato et al.   JOURNAL OF IMMUNOLOGY

Macrophage phenotypes during tissue repair

(2013) Margaret L. Novak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion

(2013) Starlee Lively et al.   Journal of Neuroinflammation

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

(2013) Yoshinori Hayashi et al.   Scientific Reports

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

CNS sterile injury: just another wound healing?

(2012) Ravid Shechter et al.   TRENDS IN MOLECULAR MEDICINE

Adiponectin receptor signalling in the brain

(2011) John Thundyil et al.   BRITISH JOURNAL OF PHARMACOLOGY

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

(2011) Carlo Perego et al.   Journal of Neuroinflammation

Selective Upregulation of Per1 mRNA Expression by ATP Through Activation of P2X7 Purinergic Receptors Expressed in Microglial Cells

(2011) Ryota Nakazato et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The nuclear receptor REV-ERB  mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

(2011) J. E. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy

(2008) S. A. Villalta et al.   HUMAN MOLECULAR GENETICS

Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep

(2008) Vladyslav V Vyazovskiy et al.   NATURE NEUROSCIENCE