BCL2 G quadruplex-binding small molecules: Current status and prospects for the development of next-generation anticancer therapeutics

New insights into the roles of antiapoptotic members of the Bcl-2 family in melanoma progression and therapy

(2021) Daniela Trisciuoglio et al.   DRUG DISCOVERY TODAY

Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-XL and BCL-2

(2021) Michael J. Roy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antisense technology: an overview and prospectus

(2021) Stanley T. Crooke et al.   NATURE REVIEWS DRUG DISCOVERY

DNA G-quadruplex structures: more than simple roadblocks to transcription?

(2021) Jenna Robinson et al.   NUCLEIC ACIDS RESEARCH

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Acute Myeloid Leukemia Patients

(2020) Shanshan Pei et al.   Cancer Discovery

Characterization of long G4-rich enhancer-associated genomic regions engaging in a novel loop:loop ‘G4 Kissing’ interaction

(2020) Jonathan D Williams et al.   NUCLEIC ACIDS RESEARCH

Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back

(2020) Prakash Kharel et al.   NUCLEIC ACIDS RESEARCH

Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives

(2019) Sveva Pelliccia et al.   JOURNAL OF MEDICINAL CHEMISTRY

A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO

(2018) Yingchun Gu et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

G-Quadruplex: A Regulator of Gene Expression and Its Chemical Targeting

(2018) Tian Tian et al.   Chem

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Synthesis and evaluation of 7-substituted-5,6-dihydrobenzo[ c ]acridine derivatives as new c- KIT promoter G-quadruplex binding ligands

(2017) Qian-Liang Guo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions

(2017) Jagannath Jana et al.   Scientific Reports

G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs

(2017) Qian Cao et al.   Inorganic Chemistry Frontiers

Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells

(2016) Emanuela Micheli et al.   BIOCHIMIE

Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog

(2016) Yun Feng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

High in vivo antitumor activity of cobalt oxoisoaporphine complexes by targeting G-quadruplex DNA, telomerase and disrupting mitochondrial functions

(2016) Qi-Pin Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules

(2016) Jeremy L. Yap et al.   JOURNAL OF MEDICINAL CHEMISTRY

A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription

(2016) Buket Onel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity, and Tumor Cell Apoptosis by Organoplatinum(II) Complexes with Oxoisoaporphine

(2015) Zhen-Feng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

(2015) Stephan A Ohnmacht et al.   Scientific Reports

The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution

(2014) Prashansa Agrawal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes

(2014) Li-Ping Bai et al.   Scientific Reports

The effect of pyridyl substituents on the thermodynamics of porphyrin binding to G-quadruplex DNA

(2013) Gerald B. Rowland et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A ruthenium(II) complex capable of inducing and stabilizing bcl-2 G-quadruplex formation as a potential cancer inhibitor

(2013) Jingnan Zhang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

(2013) Lewis R. Vidler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Xanthene and Xanthone Derivatives as G-Quadruplex Stabilizing Ligands

(2013) Alessandro Altieri et al.   MOLECULES

Bcl-2 Promoter Sequence G-Quadruplex Interactions with Three Planar and Non-Planar Cationic Porphyrins: TMPyP4, TMPyP3, and TMPyP2

(2013) Vu H. Le et al.   PLoS One

Shedding light on the interactions of guanine quadruplexes with tricationic metalloporphyrins

(2013) Ping Zhao et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity

(2012) Fong-Chun Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

G-Quadruplex Binding Ligands: from Naturally Occurring to Rationally Designed Molecules

(2012) Tuong Vy Thi Le et al.   CURRENT PHARMACEUTICAL DESIGN

Novel G-quadruplex stabilizing agents: in-silico approach and dynamics

(2012) Rajiv Kumar Kar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Biomarkers of Therapeutic Response to BCL2 Antagonists in Cancer

(2012) Lloyd T. Lam et al.   Molecular Diagnosis & Therapy

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Emulsified BMVC derivative induced filtration for G-quadruplex DNA structural separation

(2011) Y.-L. Tsai et al.   NUCLEIC ACIDS RESEARCH

Synthesis and cancer cell cytotoxicity of substituted xanthenes

(2010) Rajan Giri et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Studies on the Site and Mode of TMPyP4 Interactions with Bcl-2 Promoter Sequence G-Quadruplexes

(2010) Narayana Nagesh et al.   BIOPHYSICAL JOURNAL

Antisense Treatment in Human Prostate Cancer and Melanoma

(2010) C. Di Cresce et al.   CURRENT CANCER DRUG TARGETS

Synthesis and Biological Evaluation of Apogossypolone Derivatives as Pan-active Inhibitors of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins

(2010) Jun Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Turning off Transcription of thebcl-2Gene by Stabilizing thebcl-2Promoter Quadruplex with Quindoline Derivatives

(2010) Xiao-Dong Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

The structures of quadruplex nucleic acids and their drug complexes

(2009) Stephen Neidle   CURRENT OPINION IN STRUCTURAL BIOLOGY

p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity

(2008) Sonja Wolff et al.   CELL RESEARCH

Randomized Phase II Study of Carboplatin and Etoposide With or Without thebcl-2Antisense Oligonucleotide Oblimersen for Extensive-Stage Small-Cell Lung Cancer: CALGB 30103

(2008) Charles M. Rudin et al.   JOURNAL OF CLINICAL ONCOLOGY

BH3 Mimetic ABT-737 and a Proteasome Inhibitor Synergistically Kill Melanomas through Noxa-Dependent Apoptosis

(2008) Leslie A. Miller et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY