Human iPSC-derived cerebral organoids model features of Leigh syndrome and reveal abnormal corticogenesis
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Title
Human iPSC-derived cerebral organoids model features of Leigh syndrome and reveal abnormal corticogenesis
Authors
Keywords
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Journal
DEVELOPMENT
Volume 149, Issue 20, Pages -
Publisher
The Company of Biologists
Online
2022-07-06
DOI
10.1242/dev.199914
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Note: Only part of the references are listed.- Autism genes converge on asynchronous development of shared neuron classes
- (2022) Bruna Paulsen et al. NATURE
- Phosphoenolpyruvate Carboxykinase (PCK) in the Brain Gluconeogenic Pathway Contributes to Oxidative and Lactic Injury After Stroke
- (2021) Xiaokun Geng et al. MOLECULAR NEUROBIOLOGY
- Reactive astrocyte nomenclature, definitions, and future directions
- (2021) Carole Escartin et al. NATURE NEUROSCIENCE
- Dosage Compensation in Females with X-Linked Metabolic Disorders
- (2021) Patrycja Juchniewicz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome
- (2021) Gizem Inak et al. Nature Communications
- Histological Studies of the Ventricular–Subventricular Zone as Neural Stem Cell and Glioma Stem Cell Niche
- (2021) Asa A. Brockman et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Cell stress in cortical organoids impairs molecular subtype specification
- (2020) Aparna Bhaduri et al. NATURE
- Molecular basis of Leigh syndrome: a current look
- (2020) Manuela Baldo Schubert et al. Orphanet Journal of Rare Diseases
- Three-Dimensional Graphene Enhances Neural Stem Cell Proliferation Through Metabolic Regulation
- (2020) Qiaojun Fang et al. Frontiers in Bioengineering and Biotechnology
- Pediatric Leigh Syndrome: Neuroimaging Features and Genetic Correlations
- (2020) Cesar Augusto Pinheiro Ferreira Alves et al. ANNALS OF NEUROLOGY
- Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease
- (2020) Jaydeep Sidhaye et al. CELL DEATH AND DIFFERENTIATION
- X-linked diseases: susceptible females
- (2020) Barbara R. Migeon GENETICS IN MEDICINE
- Phenotype microarrays reveal metabolic dysregulations of neurospheres derived from embryonic Ts1Cje mouse model of Down syndrome
- (2020) Eryse Amira Seth et al. PLoS One
- Mitochondrial dynamics in postmitotic cells regulate neurogenesis
- (2020) Ryohei Iwata et al. SCIENCE
- Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems
- (2020) Piyush Joshi et al. Cell Death & Disease
- Progress and Challenges in Aminoacyl-tRNA Synthetase-based Therapeutics
- (2019) Christopher S. Francklyn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures
- (2019) Rebecca M. Marton et al. NATURE NEUROSCIENCE
- Enolase1 Alleviates Cerebral Ischemia-Induced Neuronal Injury via Its Enzymatic Product Phosphoenolpyruvate
- (2019) Wei Jiang et al. ACS Chemical Neuroscience
- Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation
- (2019) Yu-Lin Kuang et al. Stem Cell Research
- mRNA Reprogramming of T8993G Leigh's Syndrome Fibroblast Cells to Create Induced Pluripotent Stem Cell Models for Mitochondrial Disorders
- (2019) Harrison E. Grace et al. STEM CELLS AND DEVELOPMENT
- Fluorescent Gene Tagging of Transcriptionally Silent Genes in hiPSCs
- (2019) Brock Roberts et al. Stem Cell Reports
- Individual brain organoids reproducibly form cell diversity of the human cerebral cortex
- (2019) Silvia Velasco et al. NATURE
- Editorial: The Warburg Effect Regulation Under Siege: the Intertwined Pathways in Health and Disease
- (2019) Concetta Bubici et al. Frontiers in Cell and Developmental Biology
- Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation
- (2019) Isha H. Jain et al. Cell Metabolism
- Organoid single-cell genomic atlas uncovers human-specific features of brain development
- (2019) Sabina Kanton et al. NATURE
- Differentiation of neural rosettes from human pluripotent stem cells in vitro is sequentially regulated on a molecular level and accomplished by the mechanism reminiscent of secondary neurulation
- (2019) Veronika Fedorova et al. Stem Cell Research
- Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
- (2019) Matthew R. Zanotelli et al. Nature Communications
- Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos
- (2019) Bethany Muller et al. Scientific Reports
- A pipeline for multidimensional confocal analysis of mitochondrial morphology, function, and dynamics in pancreatic β-cells
- (2019) Ahsen Chaudhry et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- MetaboAnalystR: an R package for flexible and reproducible analysis of metabolomics data
- (2018) Jasmine Chong et al. BIOINFORMATICS
- Calcium signaling mediates five types of cell morphological changes to form neural rosettes
- (2018) Hana Hříbková et al. JOURNAL OF CELL SCIENCE
- Mitochondrial medicine in the omics era
- (2018) Joyeeta Rahman et al. LANCET
- Regulation of ATP utilization during metastatic cell migration by collagen architecture
- (2018) Matthew R. Zanotelli et al. MOLECULAR BIOLOGY OF THE CELL
- Novel insights into the functional metabolic impact of an apparent de novo m.8993T>G variant in the MT-ATP6 gene associated with maternally inherited form of Leigh Syndrome
- (2018) Martine Uittenbogaard et al. MOLECULAR GENETICS AND METABOLISM
- MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis
- (2018) Jasmine Chong et al. NUCLEIC ACIDS RESEARCH
- Normal aging induces A1-like astrocyte reactivity
- (2018) Laura E. Clarke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells
- (2018) Jan-Philip Medelnik et al. Stem Cell Reports
- Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers
- (2018) Jana Buzkova et al. EMBO Molecular Medicine
- The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019
- (2018) Annalisa Buniello et al. NUCLEIC ACIDS RESEARCH
- mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases
- (2018) Simon C. Johnson et al. KIDNEY INTERNATIONAL
- Reactive Astrocytes: Production, Function, and Therapeutic Potential
- (2017) Shane A. Liddelow et al. IMMUNITY
- Phenotype-genotype correlations in Leigh syndrome: new insights from a multicentre study of 96 patients
- (2017) Kalliopi Sofou et al. JOURNAL OF MEDICAL GENETICS
- SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions
- (2017) Wei Sun et al. JOURNAL OF NEUROSCIENCE
- Metabolomics of mitochondrial disease
- (2017) Karien Esterhuizen et al. MITOCHONDRION
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Guided self-organization and cortical plate formation in human brain organoids
- (2017) Madeline A Lancaster et al. NATURE BIOTECHNOLOGY
- Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells
- (2017) Yuchen Qi et al. NATURE BIOTECHNOLOGY
- The use of brain organoids to investigate neural development and disease
- (2017) Elizabeth Di Lullo et al. NATURE REVIEWS NEUROSCIENCE
- Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome
- (2017) Michele Ferrari et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human aminoacyl-tRNA synthetases in diseases of the nervous system
- (2017) Jana Ognjenović et al. RNA Biology
- Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells
- (2017) Abinaya Chandrasekaran et al. Stem Cell Research
- Concise Review: Induced Pluripotent Stem Cell-Based Drug Discovery for Mitochondrial Disease
- (2017) Gizem Inak et al. STEM CELLS
- Pathophysiological Role of Purines and Pyrimidines in Neurodevelopment: Unveiling New Pharmacological Approaches to Congenital Brain Diseases
- (2017) Marta Fumagalli et al. Frontiers in Pharmacology
- An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells
- (2017) Julia TCW et al. Stem Cell Reports
- BioCircos.js: an interactive Circos JavaScript library for biological data visualization on web applications
- (2016) Ya Cui et al. BIOINFORMATICS
- Cellular Metabolism and Induced Pluripotency
- (2016) Jun Wu et al. CELL
- Stem Cell Models of Human Brain Development
- (2016) Iva Kelava et al. Cell Stem Cell
- Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program
- (2016) Mireille Khacho et al. Cell Stem Cell
- The many faces of paediatric mitochondrial disease on neuroimaging
- (2016) Fabian Baertling et al. CHILDS NERVOUS SYSTEM
- Single cell analysis of human tissues and solid tumors with mass cytometry
- (2016) Nalin Leelatian et al. CYTOMETRY PART B-CLINICAL CYTOMETRY
- Leigh syndrome: Resolving the clinical and genetic heterogeneity paves the way for treatment options
- (2016) Mike Gerards et al. MOLECULAR GENETICS AND METABOLISM
- Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
- (2016) Navdeep S. Chandel et al. NATURE CELL BIOLOGY
- The promises and challenges of human brain organoids as models of neuropsychiatric disease
- (2016) Giorgia Quadrato et al. NATURE MEDICINE
- Hypoxia as a therapy for mitochondrial disease
- (2016) I. H. Jain et al. SCIENCE
- Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene
- (2016) Teresa Galera-Monge et al. Stem Cell Research
- Rotary ATPases: A New Twist to an Ancient Machine
- (2016) Werner Kühlbrandt et al. TRENDS IN BIOCHEMICAL SCIENCES
- Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration
- (2016) Xinde Zheng et al. eLife
- Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation
- (2016) Xinde Zheng et al. eLife
- Leigh syndrome: One disorder, more than 75 monogenic causes
- (2015) Nicole J. Lake et al. ANNALS OF NEUROLOGY
- Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning
- (2015) Anthony P. Leonard et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Dynamic Expression Patterns of Progenitor and Neuron Layer Markers in the Developing Human Dentate Gyrus and Fimbria
- (2015) Sara Cipriani et al. CEREBRAL CORTEX
- Leigh Syndrome
- (2015) Nicole J. Lake et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Metabolic rescue in pluripotent cells from patients with mtDNA disease
- (2015) Hong Ma et al. NATURE
- Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
- (2015) Anca M Paşca et al. NATURE METHODS
- Proliferation control in neural stem and progenitor cells
- (2015) Catarina C. F. Homem et al. NATURE REVIEWS NEUROSCIENCE
- Neural progenitors, neurogenesis and the evolution of the neocortex
- (2014) M. Florio et al. DEVELOPMENT
- Two Novel Mutations in theBCKDK(Branched-Chain Keto-Acid Dehydrogenase Kinase) Gene Are Responsible for a Neurobehavioral Deficit in Two Pediatric Unrelated Patients
- (2014) Angels García-Cazorla et al. HUMAN MUTATION
- Generation of cerebral organoids from human pluripotent stem cells
- (2014) Madeline A Lancaster et al. Nature Protocols
- Mitochondrial Morphological Features Are Associated with Fission and Fusion Events
- (2014) Laura M. Westrate et al. PLoS One
- Comparison and Optimization of hiPSC Forebrain Cortical Differentiation Protocols
- (2014) Christina R. Muratore et al. PLoS One
- Mitochondrial network morphology: building an integrative, geometrical view
- (2013) Susanne M Rafelski BMC BIOLOGY
- A guide to diagnosis and treatment of Leigh syndrome
- (2013) F. Baertling et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Mitochondrial Gene Therapy Improves Respiration, Biogenesis, and Transcription in G11778A Leber's Hereditary Optic Neuropathy and T8993G Leigh's Syndrome Cells
- (2012) Shilpa Iyer et al. HUMAN GENE THERAPY
- Genomic Analysis of Reactive Astrogliosis
- (2012) J. L. Zamanian et al. JOURNAL OF NEUROSCIENCE
- A role for the Warburg effect in preimplantation embryo development: Metabolic modification to support rapid cell proliferation
- (2012) Rebecca L. Krisher et al. MOLECULAR REPRODUCTION AND DEVELOPMENT
- Metabolic differentiation in the embryonic retina
- (2012) Michalis Agathocleous et al. NATURE CELL BIOLOGY
- Dynamic Microenvironments: The Fourth Dimension
- (2012) M. W. Tibbitt et al. Science Translational Medicine
- Emergence of the Mitochondrial Reticulum from Fission and Fusion Dynamics
- (2012) Valerii M. Sukhorukov et al. PLoS Computational Biology
- Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift
- (2012) Pablo Cingolani et al. Frontiers in Genetics
- Development and Evolution of the Human Neocortex
- (2011) Jan H. Lui et al. CELL
- Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation
- (2011) Mireille Bélanger et al. Cell Metabolism
- Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming
- (2011) Clifford D.L. Folmes et al. Cell Metabolism
- SOX2 expression levels distinguish between neural progenitor populations of the developing dorsal telencephalon
- (2011) Scott R. Hutton et al. DEVELOPMENTAL BIOLOGY
- UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells
- (2011) Jin Zhang et al. EMBO JOURNAL
- Chemically defined conditions for human iPSC derivation and culture
- (2011) Guokai Chen et al. NATURE METHODS
- A bioinformatic assay for pluripotency in human cells
- (2011) Franz-Josef Müller et al. NATURE METHODS
- Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst
- (2011) Jianguo Xia et al. Nature Protocols
- The stem cell potential of glia: lessons from reactive gliosis
- (2011) Stefanie Robel et al. NATURE REVIEWS NEUROSCIENCE
- The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling
- (2010) Anatoly A. Starkov Annals of the New York Academy of Sciences
- MetPA: a web-based metabolomics tool for pathway analysis and visualization
- (2010) J. Xia et al. BIOINFORMATICS
- Neocortical Layer Formation of Human Developing Brains and Lissencephalies: Consideration of Layer-Specific Marker Expression
- (2010) Takashi Saito et al. CEREBRAL CORTEX
- Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons
- (2010) Nader D. Halim et al. GLIA
- Expression of the Homeobox Genes OTX2 and OTX1 in the Early Developing Human Brain
- (2010) Karen B. Larsen et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation
- (2010) Susan Chung et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Metabolic oxidation regulates embryonic stem cell differentiation
- (2010) Oscar Yanes et al. Nature Chemical Biology
- Mitochondrial Rejuvenation After Induced Pluripotency
- (2010) Steven T. Suhr et al. PLoS One
- The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells
- (2010) Alessandro Prigione et al. STEM CELLS
- Mitochondrial Function Controls Proliferation and Early Differentiation Potential of Embryonic Stem Cells
- (2010) Sudip Mandal et al. STEM CELLS
- Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
- (2010) Robert B. Hamanaka et al. TRENDS IN BIOCHEMICAL SCIENCES
- Conditional deletion of β1-integrin in astroglia causes partial reactive gliosis
- (2009) Stefanie Robel et al. GLIA
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
- (2009) Stuart M Chambers et al. NATURE BIOTECHNOLOGY
- MetaboAnalyst: a web server for metabolomic data analysis and interpretation
- (2009) J. Xia et al. NUCLEIC ACIDS RESEARCH
- The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis
- (2009) Stephen N. Sansom et al. PLoS Genetics
- The determination of projection neuron identity in the developing cerebral cortex
- (2008) Dino P Leone et al. CURRENT OPINION IN NEUROBIOLOGY
- Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage
- (2008) Y. Elkabetz et al. GENES & DEVELOPMENT
- Proline Affects Brain Function in 22q11DS Children with the Low Activity COMT158 Allele
- (2008) Jacob A S Vorstman et al. NEUROPSYCHOPHARMACOLOGY
- Cytidine-5-diphosphocholine supplement in early life induces stable increase in dendritic complexity of neurons in the somatosensory cortex of adult rats
- (2008) V. Rema et al. NEUROSCIENCE
- Leigh and Leigh-Like Syndrome in Children and Adults
- (2008) Josef Finsterer PEDIATRIC NEUROLOGY
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