Proliferation control in neural stem and progenitor cells

Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia

(2015) Alissa M. D'Gama et al.   ANNALS OF NEUROLOGY

Neural stem cell progeny regulate stem cell death in a Notch and Hox dependent manner

(2015) R Arya et al.   CELL DEATH AND DIFFERENTIATION

A Conserved Regulatory Logic Controls Temporal Identity in Mouse Neural Progenitors

(2015) Pierre Mattar et al.   NEURON

Megalencephaly and hemimegalencephaly: Breakthroughs in molecular etiology

(2014) Ghayda M. Mirzaa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells

(2014) Catarina C.F. Homem et al.   CELL

SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells

(2014) Elif Eroglu et al.   CELL

Deterministic Progenitor Behavior and Unitary Production of Neurons in the Neocortex

(2014) Peng Gao et al.   CELL

Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors

(2014) D. H. Janssens et al.   DEVELOPMENT

Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Drosophila Neural Stem Cells

(2014) Pauline Spéder et al.   DEVELOPMENTAL CELL

Control of brain development and homeostasis by local and systemic insulin signalling

(2014) J. Liu et al.   DIABETES OBESITY & METABOLISM

The TRIM-NHL Protein Brat Promotes Axon Maintenance by Repressingsrc64BExpression

(2014) Giovanni Marchetti et al.   JOURNAL OF NEUROSCIENCE

Radial glia require PDGFD–PDGFRβ signalling in human but not mouse neocortex

(2014) Jan H. Lui et al.   NATURE

De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome

(2014) Ghayda M Mirzaa et al.   NATURE GENETICS

Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy

(2014) Carol-Anne Martin et al.   NATURE GENETICS

Cortical neurogenesis in the absence of centrioles

(2014) Ryan Insolera et al.   NATURE NEUROSCIENCE

The Drosophila Sp8 transcription factor Buttonhead prevents premature differentiation of intermediate neural progenitors

(2014) Yonggang Xie et al.   eLife

Trithorax maintains the functional heterogeneity of neural stem cells through the transcription factor Buttonhead

(2014) Hideyuki Komori et al.   eLife

The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages

(2014) Chwee Tat Koe et al.   eLife

Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division

(2014) Felipe Mora-Bermúdez et al.   eLife

Asymmetric Inheritance of Centrosome-Associated Primary Cilium Membrane Directs Ciliogenesis after Cell Division

(2013) Judith T.M.L. Paridaen et al.   CELL

Coffin-Siris syndrome is a SWI/SNF complex disorder

(2013) Y. Tsurusaki et al.   CLINICAL GENETICS

Drosophila intermediate neural progenitors produce lineage-dependent related series of diverse neurons

(2013) Y.-C. Wang et al.   DEVELOPMENT

A temporal mechanism that produces neuronal diversity in the Drosophila visual center

(2013) Takumi Suzuki et al.   DEVELOPMENTAL BIOLOGY

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly

(2013) Yu-Chih Lin et al.   EMBO JOURNAL

Dynamic Interactions between Intermediate Neurogenic Progenitors and Radial Glia in Embryonic Mouse Neocortex: Potential Role in Dll1-Notch Signaling

(2013) B. R. Nelson et al.   JOURNAL OF NEUROSCIENCE

Combinatorial temporal patterning in progenitors expands neural diversity

(2013) Omer Ali Bayraktar et al.   NATURE

Temporal patterning of Drosophila medulla neuroblasts controls neural fates

(2013) Xin Li et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

The microcephaly protein Asp regulates neuroepithelium morphogenesis by controlling the spatial distribution of myosin II

(2013) Maria A. Rujano et al.   NATURE CELL BIOLOGY

Temporal fate specification and neural progenitor competence during development

(2013) Minoree Kohwi et al.   NATURE REVIEWS NEUROSCIENCE

Fezf2 Expression Identifies a Multipotent Progenitor for Neocortical Projection Neurons, Astrocytes, and Oligodendrocytes

(2013) Chao Guo et al.   NEURON

Precursor Diversity and Complexity of Lineage Relationships in the Outer Subventricular Zone of the Primate

(2013) Marion Betizeau et al.   NEURON

Long-Term Live Cell Imaging and Automated 4D Analysis of Drosophila Neuroblast Lineages

(2013) Catarina C. F. Homem et al.   PLoS One

Ikaros promotes early-born neuronal fates in the cerebral cortex

(2013) J. M. Alsio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection of Neuronal Diversity at the Expense of Neuronal Numbers during Nutrient Restriction in the Drosophila Visual System

(2013) Elodie Lanet et al.   Cell Reports

Hedgehog Signaling Acts with the Temporal Cascade to Promote Neuroblast Cell Cycle Exit

(2013) Phing Chian Chai et al.   PLOS BIOLOGY

A Truncating Mutation of CEP135 Causes Primary Microcephaly and Disturbed Centrosomal Function

(2012) Muhammad Sajid Hussain et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Balancing self-renewal and differentiation by asymmetric division: Insights from brain tumor suppressors in Drosophila neural stem cells

(2012) Kai Chen Chang et al.   BIOESSAYS

Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity

(2012) Inês Pinheiro et al.   CELL

Drosophila neuroblasts: a model for stem cell biology

(2012) C. C. F. Homem et al.   DEVELOPMENT

bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation

(2012) E. Zacharioudaki et al.   DEVELOPMENT

klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division

(2012) Q. Xiao et al.   DEVELOPMENT

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

Endocytosis by Numb breaks Notch symmetry at cytokinesis

(2012) Lydie Couturier et al.   NATURE CELL BIOLOGY

Intralineage Directional Notch Signaling Regulates Self-Renewal and Differentiation of Asymmetrically Dividing Radial Glia

(2012) Zhiqiang Dong et al.   NEURON

Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations

(2012) Annapurna Poduri et al.   NEURON

Imaginal Discs Secrete Insulin-Like Peptide 8 to Mediate Plasticity of Growth and Maturation

(2012) A. Garelli et al.   SCIENCE

Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing

(2012) J. Colombani et al.   SCIENCE

Fate-Restricted Neural Progenitors in the Mammalian Cerebral Cortex

(2012) S. J. Franco et al.   SCIENCE

FACS Purification and Transcriptome Analysis of Drosophila Neural Stem Cells Reveals a Role for Klumpfuss in Self-Renewal

(2012) Christian Berger et al.   Cell Reports

Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome

(2012) Rebecca E. McIntyre et al.   PLoS Genetics

Genetic causes of microcephaly and lessons for neuronal development

(2012) Edward C. Gilmore et al.   Wiley Interdisciplinary Reviews-Developmental Biology

PRDM proteins: Important players in differentiation and disease

(2011) Cathrine K. Fog et al.   BIOESSAYS

Development and Evolution of the Human Neocortex

(2011) Jan H. Lui et al.   CELL

Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila

(2011) Louise Y. Cheng et al.   CELL

Abundant Occurrence of Basal Radial Glia in the Subventricular Zone of Embryonic Neocortex of a Lissencephalic Primate, the Common Marmoset Callithrix jacchus

(2011) Iva Kelava et al.   CEREBRAL CORTEX

The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila

(2011) Beatriz P. San-Juán et al.   DEVELOPMENTAL BIOLOGY

Brat Promotes Stem Cell Differentiation via Control of a Bistable Switch that Restricts BMP Signaling

(2011) Robin E. Harris et al.   DEVELOPMENTAL CELL

Regulating the balance between symmetric and asymmetric stem cell division in the developing brain

(2011) Boris Egger et al.   FLY

Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila

(2011) Y. Song et al.   GENES & DEVELOPMENT

ASPM regulates Wnt signaling pathway activity in the developing brain

(2011) J. J. Buchman et al.   GENES & DEVELOPMENT

Oblique Radial Glial Divisions in the Developing Mouse Neocortex Induce Self-Renewing Progenitors outside the Germinal Zone That Resemble Primate Outer Subventricular Zone Progenitors

(2011) A. Shitamukai et al.   JOURNAL OF NEUROSCIENCE

Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila

(2011) Rita Sousa-Nunes et al.   NATURE

MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1–Cdc25 pathway

(2011) Ralph Gruber et al.   NATURE CELL BIOLOGY

A primary microcephaly protein complex forms a ring around parental centrioles

(2011) Joo-Hee Sir et al.   NATURE GENETICS

The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells

(2011) Maria K. Lehtinen et al.   NEURON

Mouse Inscuteable Induces Apical-Basal Spindle Orientation to Facilitate Intermediate Progenitor Generation in the Developing Neocortex

(2011) Maria Pia Postiglione et al.   NEURON

Notch in the Vertebrate Nervous System: An Old Dog with New Tricks

(2011) Tarran Pierfelice et al.   NEURON

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains

(2011) S. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mediator and human disease

(2011) Jason M. Spaeth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Drosophila neuroblasts retain the daughter centrosome

(2011) Jens Januschke et al.   Nature Communications

Neural stem and progenitor cells shorten S-phase on commitment to neuron production

(2011) Yoko Arai et al.   Nature Communications

Mutations in Centrosomal Protein CEP152 in Primary Microcephaly Families Linked to MCPH4

(2010) Duane L. Guernsey et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Nutrition-Responsive Glia Control Exit of Neural Stem Cells from Quiescence

(2010) James M. Chell et al.   CELL

A Role for Intermediate Radial Glia in the Tangential Expansion of the Mammalian Cerebral Cortex

(2010) Isabel Reillo et al.   CEREBRAL CORTEX

Inactivation of Both foxo and reaper Promotes Long-Term Adult Neurogenesis in Drosophila

(2010) Sarah E. Siegrist et al.   CURRENT BIOLOGY

Cnn Dynamics Drive Centrosome Size Asymmetry to Ensure Daughter Centriole Retention in Drosophila Neuroblasts

(2010) Paul T. Conduit et al.   CURRENT BIOLOGY

CDK5RAP2 Regulates Centriole Engagement and Cohesion in Mice

(2010) Jose A. Barrera et al.   DEVELOPMENTAL CELL

dFezf/Earmuff Maintains the Restricted Developmental Potential of Intermediate Neural Progenitors in Drosophila

(2010) Mo Weng et al.   DEVELOPMENTAL CELL

DrosophilaAna2 is a conserved centriole duplication factor

(2010) Naomi R. Stevens et al.   JOURNAL OF CELL BIOLOGY

Heterogeneity in Ventricular Zone Neural Precursors Contributes to Neuronal Fate Diversity in the Postnatal Neocortex

(2010) E. K. Stancik et al.   JOURNAL OF NEUROSCIENCE

Developmental genetics of vertebrate glial–cell specification

(2010) David H. Rowitch et al.   NATURE

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

(2010) Kaya Bilgüvar et al.   NATURE

Asterless is a scaffold for the onset of centriole assembly

(2010) Nikola S. Dzhindzhev et al.   NATURE

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

(2010) Timothy W Yu et al.   NATURE GENETICS

WDR62 is associated with the spindle pole and is mutated in human microcephaly

(2010) Adeline K Nicholas et al.   NATURE GENETICS

Thalamic interneurons and relay cells use complementary synaptic mechanisms for visual processing

(2010) Xin Wang et al.   NATURE NEUROSCIENCE

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

(2010) Simone A Fietz et al.   NATURE NEUROSCIENCE

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Cdk5rap2 Interacts with Pericentrin to Maintain the Neural Progenitor Pool in the Developing Neocortex

(2010) Joshua J. Buchman et al.   NEURON

Mutations in STIL, Encoding a Pericentriolar and Centrosomal Protein, Cause Primary Microcephaly

(2009) Arun Kumar et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of Tissue Growth through Nutrient Sensing

(2009) Ville Hietakangas et al.   Annual Review of Genetics

Cdk4/CyclinD1 Overexpression in Neural Stem Cells Shortens G1, Delays Neurogenesis, and Promotes the Generation and Expansion of Basal Progenitors

(2009) Christian Lange et al.   Cell Stem Cell

Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells

(2009) Masakazu Namihira et al.   DEVELOPMENTAL CELL

Asymmetric centrosome inheritance maintains neural progenitors in the neocortex

(2009) Xiaoqun Wang et al.   NATURE

Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition

(2009) Yusuke Hirabayashi et al.   NEURON

Mammalian Par3 Regulates Progenitor Cell Asymmetric Division via Notch Signaling in the Developing Neocortex

(2009) Ronald S. Bultje et al.   NEURON

Forced G1-phase reduction alters mode of division, neuron number, and laminar phenotype in the cerebral cortex

(2009) L.-J. Pilaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal Transcription Factors and Their Targets Schedule the End of Neural Proliferation in Drosophila

(2008) Cédric Maurange et al.   CELL

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon

(2008) D. Kawaguchi et al.   DEVELOPMENT

The Tumor Suppressors Brat and Numb Regulate Transit-Amplifying Neuroblast Lineages in Drosophila

(2008) Sarah K. Bowman et al.   DEVELOPMENTAL CELL

The TOR Pathway Couples Nutrition and Developmental Timing in Drosophila

(2008) Sophie Layalle et al.   DEVELOPMENTAL CELL

An intrinsic mechanism of corticogenesis from embryonic stem cells

(2008) Nicolas Gaspard et al.   NATURE

Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development

(2008) Hayato Naka et al.   NATURE NEUROSCIENCE

Mind Bomb 1-Expressing Intermediate Progenitors Generate Notch Signaling to Maintain Radial Glial Cells

(2008) Ki-Jun Yoon et al.   NEURON

Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors

(2008) Hiromi Shimojo et al.   NEURON