BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells

EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: In Vivo and in Vitro Rat Studies

(2020) Ali Alhoshani et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway

(2020) Sabah Akhtar et al.   SEMINARS IN CANCER BIOLOGY

Efficacy and Safety of Bcl-2 Inhibitor Venetoclax in Hematological Malignancy: A Systematic Review and Meta-Analysis of Clinical Trials

(2019) Qingfang Li et al.   Frontiers in Pharmacology

Combined Bcl-2/Src inhibition synergize to deplete stem-like breast cancer cells

(2019) Qi Sun et al.   CANCER LETTERS

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via Retinoblastoma protein.

(2018) Shakhawoat Hossain et al.   MOLECULAR AND CELLULAR BIOLOGY

Bcl-2 inhibition sensitizes triple-negative human breast cancer cells to doxorubicin

(2018) Touko Inao et al.   Oncotarget

BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose

(2018) Federico Lucantoni et al.   Oncotarget

Phase I First-in-Human Study of Venetoclax in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

(2017) Matthew S. Davids et al.   JOURNAL OF CLINICAL ONCOLOGY

FoxO3a is Essential for the Antiproliferative and Apoptogenic Effects of Sunitinib in MDA-MB231 Cell Line

(2016) HESHAM M KORASHY et al.   ANTICANCER RESEARCH

BCL2 as a Subtype-Specific Prognostic Marker for Breast Cancer

(2016) Yong Hwa Eom et al.   Journal of Breast Cancer

Molecular mechanisms of cardiotoxicity of gefitinib in vivo and in vitro rat cardiomyocyte: Role of apoptosis and oxidative stress

(2016) Hesham M. Korashy et al.   TOXICOLOGY LETTERS

Synergistic effects of combined treatment with histone deacetylase inhibitor suberoylanilide hydroxamic acid and TRAIL on human breast cancer cells

(2016) Weiqiang Zhou et al.   Scientific Reports

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Bim directly antagonizes Bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53

(2015) Min-Chi Yang et al.   CELL CYCLE

BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis

(2015) C. J. Gibson et al.   CLINICAL CANCER RESEARCH

Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile

(2015) KENGO KURODA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Production of novel vinegar having antioxidant and anti-fatigue activities fromSalicornia herbaceaL.

(2015) Hyun-Dong Cho et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer

(2015) D Merino et al.   ONCOGENE

Overexpression of interleukin-18 protein reduces viability and induces apoptosis of tongue squamous cell carcinoma cells by activation of glycogen synthase kinase-3β signaling

(2015) WEIWEI LIU et al.   ONCOLOGY REPORTS

Assessing reproductive toxicity of two environmental toxicants with a novel in vitro human spermatogenic model

(2015) Charles A. Easley et al.   Stem Cell Research

Glucose promotes breast cancer aggression and reduces metformin efficacy

(2013) Reema Wahdan-Alaswad et al.   CELL CYCLE

Direct Interaction of Bax and Bak Proteins with Bcl-2 Homology Domain 3 (BH3)-only Proteins in Living Cells Revealed by Fluorescence Complementation

(2013) Laura Vela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Silencing of Bcl-2 by Systemically Administered siRNA Nanotherapeutics Inhibits Tumor Growth by Autophagy and Apoptosis and Enhances the Efficacy of Chemotherapy in Orthotopic Xenograft Models of ER (−) and ER (+) Breast Cancer

(2013) Ibrahim Tekedereli et al.   Molecular Therapy-Nucleic Acids

Induction of G1 cell cycle arrest and cyclin D1 down-regulation in response to pericarp extract of Baneh in human breast cancer T47D cells

(2012) Parisa Rezaei et al.   DARU-Journal of Pharmaceutical Sciences

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Incidence of Breast Cancer and Its Subtypes in Relation to Individual and Multiple Low-Penetrance Genetic Susceptibility Loci

(2010) Gillian K. Reeves et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bcl-2 and Bax Interact via the BH1–3 Groove-BH3 Motif Interface and a Novel Interface Involving the BH4 Motif

(2010) Jingzhen Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin D1 Degradation Is Sufficient to Induce G1 Cell Cycle Arrest despite Constitutive Expression of Cyclin E2 in Ovarian Cancer Cells

(2009) C. P. Masamha et al.   CANCER RESEARCH

Mimicking the BH3 domain to kill cancer cells

(2009) T Ni Chonghaile et al.   ONCOGENE

Regulation of pro-apoptotic BH3-only proteins and its contribution to cancer progression and chemoresistance

(2008) Jose L. Fernandez-Luna   CELLULAR SIGNALLING