Article
Oncology
Shengqin Su, Mary Ann Ndiaye, Glorimar Guzman-Perez, Rebecca Michael Baus, Wei Huang, Manish Suresh Patankar, Nihal Ahmad
Summary: In this study, the researchers investigated the potential involvement of PLK5 in multiple cancers. They found a downregulation of PLK5 expression in these cancers, and further validated their findings using public databases. This study suggests that PLK5 may play a role as a tumor suppressor.
Review
Pharmacology & Pharmacy
Styliani Iliaki, Rudi Beyaert, Inna S. Afonina
Summary: PLK1 is a Ser/Thr kinase that plays crucial roles in cell cycle regulation, DNA damage response, apoptosis, and cancer progression. Overexpression of PLK1 is associated with poor prognosis in cancer, making it an attractive therapeutic target.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Oncology
Xiaoyang Zhang, Cheng Wei, Hao Liang, Lei Han
Summary: Polo-like kinases (Plks) family consists of five members, with Plk4 playing a crucial role in centriole replication and being closely associated with cancer development. This review describes the molecular structure and regulation of Plk4, lists its downstream targets and cancer hallmarks, and summarizes its role in different cancers. Additionally, it reviews inhibitors targeting Plk4 for potential anticancer drug discovery.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Monika Kressin, Daniela Fietz, Sven Becker, Klaus Strebhardt
Summary: Polo-like kinases (PLKs) are a group of highly conserved serine/threonine kinases that play crucial roles in tumorigenesis, particularly with the overexpression of PLK1 being associated with poor prognosis in different cancers. Current research is focusing on investigating the multiple functions of PLKs and their potential as cancer targets, with a specific emphasis on PLK1 and PLK4 inhibition in various cancer trials.
Review
Oncology
Chuanyong Zhang, Chuangye Ni, Hao Lu
Summary: PLK2 plays an important role in the cell cycle, cell differentiation, and maintaining neural homeostasis. Dysfunction of PLK2 can lead to cell cycle disorders and developmental retardation. Additionally, PLK2 may promote cell survival or apoptosis in response to stress stimuli. However, research on the role of PLK2 in immunity to viral infection is limited compared to other family members.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eshaan Patnaik, Chikezie Madu, Yi Lu
Summary: Epigenetics plays a crucial role in gene regulation and tumor development. DNA methylation inhibitors and histone deacetylase inhibitors can restore normal gene expression and be effective against cancer. Understanding epigenetic modifications and utilizing inhibitors offer new possibilities for cancer research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Shuying Sun, Austin Zane, Carolyn Fulton, Jasmine Philipoom
Summary: This study investigates hemimethylation in lung cancer for the first time, demonstrating the existence of hemimethylation in lung cells and its potential association with the development of normal and tumor cells. Hemimethylation patterns are diverse and comparable between normal and tumor cells, with identified genes showing differential hemimethylation that may impact gene expression and cell function in non-small cell lung cancer.
Article
Cell Biology
Chun-Hua Wang, Tzung-Ju Lu, Lu-Kai Wang, Chang-Chieh Wu, Mao-Liang Chen, Chan-Yen Kuo, Rong-Yaun Shyu, Fu-Ming Tsai
Summary: The study revealed that TIG1 regulates the tumorigenesis of CRC by modulating the activity of PLK2. The expression of PLK2 in CRC cells is associated with low levels of Fbxw7 protein and increased expression of cyclin E1. The findings suggest a potential mechanism for CRC development and progression involving the interaction between TIG1 and PLK2.
CELL BIOLOGY INTERNATIONAL
(2021)
Review
Chemistry, Medicinal
Yang Shu, Yajing Liu, Shirong Bian, Zhouling Xie, Chenzhong Liao
Summary: Polo-like kinase 4 (PLK4) is a key regulator of the cell cycle that controls centrosome duplication and mitosis. It has been identified as a promising target for cancer therapy, and PLK4 inhibitors have shown potential for treating various cancers and other PLK4-associated human disorders. In addition, PLK4 may have a role in sensitizing DNA damage, thus improving the efficacy of chemotherapy. However, there is still limited understanding of PLK4, and further research is needed to identify novel mechanisms.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Oncology
Alma Jaqueline Heredia-Mendez, Gricelda Sanchez-Sanchez, Cesar Lopez-Camarillo
Summary: During the last century, 2D cell cultures have been commonly used to study cancer biology, drug discovery, genomics, and gene expression regulation. However, this approach has limitations in accurately reproducing the tumor microenvironment and cellular processes. To overcome these limitations, 3D cell cultures have been implemented to better mimic the biological and molecular features of tumors. This review discusses the application of different types of 3D cell culture models to characterize the epigenetic changes in cancer cells, particularly DNA methylation patterns, and the impact of microenvironmental factors on these changes.
Article
Chemistry, Medicinal
Rameswari Chilamakuri, Danielle Crystal Rouse, Saurabh Agarwal
Summary: Analysis revealed the negative correlation between PLK1 expression and survival of NB patients, as well as its association with disease progression. HMN-214 effectively inhibits NB proliferation and cell cycle, with significant anti-tumor effects in a 3D spheroid tumor model.
Review
Cell Biology
Dipanwita Das, Nandini Karthik, Reshma Taneja
Summary: Inflammation is a crucial immune response against infection and tissue damage, but chronic inflammation is linked to cancer development. Immune cells produce inflammatory mediators to facilitate tumor growth, while aberrant expression of inflammatory factors by tumor cells recruits immune cells for mutual crosstalk, creating a conducive environment for tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jasvinder Singh, Bindeshwar Sah, Yao Shen, Liang Liu
Summary: This study found that UNC0642 can induce breast cancer cell death by upregulating TXNIP expression and oxidative stress. This discovery could provide a new target for future breast cancer therapies.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Genetics & Heredity
Ester Molina, Linda Hong, IIana Chefetz
Summary: LKB1 and AMPK alpha play crucial roles in cancer development by sensing and regulating energy requirements in tumor cells. In addition to these, there are multiple AMPK-like downstream targets of LKB1 involved in various cellular processes such as cell cycle progression, cell polarity, metabolism, and mitotic regulation.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Parasitology
Eun-Ah Park, Juri Kim, Mee Young Shin, Soon-Jung Park
Summary: The study reveals the role of GlPLK in Giardia cell division, especially during cytokinesis, and its involvement in flagella formation.
PARASITES & VECTORS
(2021)
