The role of nitric oxide in sepsis-associated kidney injury

Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice

(2022) Gustavo Ferreira Alves et al.   Frontiers in Immunology

Pathophysiology of sepsis-induced cardiomyopathy

(2021) Steven M. Hollenberg et al.   Nature Reviews Cardiology

Pathophysiology of sepsis

(2021) Pietro Arina et al.   Current Opinion in Anesthesiology

Pretreatment with S-Nitrosoglutathione Attenuates Septic Acute Kidney Injury in Rats by Inhibiting Inflammation, Oxidation, and Apoptosis

(2021) Heng Fan et al.   Biomed Research International

Nitric oxide signalling in kidney regulation and cardiometabolic health

(2021) Mattias Carlström   Nature Reviews Nephrology

Targeting Oxidative Stress in Septic Acute Kidney Injury: From Theory to Practice

(2021) Connie P. C. Ow et al.   Journal of Clinical Medicine

Inhibition of Bruton's Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats

(2021) Nikita M. Patel et al.   ANNALS OF SURGERY

SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties

(2021) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

(2021) Thiele Osvaldt Rosales et al.   CLINICAL SCIENCE

Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury

(2021) Grietje Molema et al.   Nature Reviews Nephrology

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway

(2020) V. Kapil et al.   PHARMACOLOGICAL REVIEWS

Immunopathophysiology of trauma-related acute kidney injury

(2020) David A. C. Messerer et al.   Nature Reviews Nephrology

Bruton’s tyrosine kinase inhibition attenuates oxidative stress in systemic immune cells and renal compartment during sepsis-induced acute kidney injury in mice

(2020) Ahmed Nadeem et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock

(2019) Glenn Hernández et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Furosemide on Urinary Oxygenation in Patients with Septic Shock

(2019) Eduardo Atsushi Osawa et al.   BLOOD PURIFICATION

Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment

(2019) Sadudee Peerapornratana et al.   KIDNEY INTERNATIONAL

The therapeutic value of protein (de)nitrosylation in experimental septic shock

(2018) Patrícia O. Benedet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Physiological activation and deactivation of soluble guanylate cyclase

(2018) Benjamin G. Horst et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Acute Kidney Injury and Sepsis

(2018) Steven J. Skube et al.   Surgical Infections

Nitrite and nitrate chemical biology and signaling

(2018) Anthony W DeMartino et al.   BRITISH JOURNAL OF PHARMACOLOGY

Global epidemiology and outcomes of acute kidney injury

(2018) Eric A. J. Hoste et al.   Nature Reviews Nephrology

Protective role of cGMP in early sepsis

(2017) Vanessa Kovalski et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Acute kidney injury in sepsis

(2017) Rinaldo Bellomo et al.   INTENSIVE CARE MEDICINE

Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis

(2017) Florence L. Johnson et al.   Journal of the American Heart Association

Vasoplegia in sepsis depends on the vascular system, vasopressor, and time-point: a comparative evaluation in vessels from rats subjected to the cecal ligation puncture model

(2016) Angélica K. Bernardelli et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Recent knowledge on the pathophysiology of septic acute kidney injury: A narrative review

(2016) Hoi-Ping Shum et al.   JOURNAL OF CRITICAL CARE

AKI and Long-Term Risk for Cardiovascular Events and Mortality

(2016) Ayodele Odutayo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

Neuronal Nitric Oxide Synthase is Involved in Vascular Hyporeactivity and Multiple Organ Dysfunction Associated with Hemorrhagic Shock

(2016) Regina Sordi et al.   SHOCK

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

(2016) Paula Giselle Czaikoski et al.   PLoS One

Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVS

(2015) Andreas Papapetropoulos et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cortical and Medullary Tissue Perfusion and Oxygenation in Experimental Septic Acute Kidney Injury

(2015) Paolo Calzavacca et al.   CRITICAL CARE MEDICINE

Reduction in renal blood flow following administration of norepinephrine and phenylephrine in septic rats treated with Kir6.1 ATP-sensitive and KCa1.1 calcium-activated K+ channel blockers

(2015) Bruna da Rosa Maggi Sant’Helena et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

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(2015) Regina Sordi et al.   MOLECULAR MEDICINE

High-mobility group box 1 (HMGB1) impaired cardiac excitation–contraction coupling by enhancing the sarcoplasmic reticulum (SR) Ca2+ leak through TLR4–ROS signaling in cardiomyocytes

(2014) Cuicui Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nitric oxide in the normal kidney and in patients with diabetic nephropathy

(2014) Paolo Tessari   JOURNAL OF NEPHROLOGY

The renal microcirculation in sepsis

(2014) B. Ergin et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

World Incidence of AKI: A Meta-Analysis

(2013) P. Susantitaphong et al.   Clinical Journal of the American Society of Nephrology

Renal Histopathology During Experimental Septic Acute Kidney Injury and Recovery*

(2013) Christoph Langenberg et al.   CRITICAL CARE MEDICINE

Inhibition of I B kinase reduces the multiple organ dysfunction caused by sepsis in the mouse

(2013) S. M. Coldewey et al.   Disease Models & Mechanisms

Pneumonia-induced sepsis in mice: temporal study of inflammatory and cardiovascular parameters

(2013) Regina Sordi et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The Soluble Guanylate Cyclase Activator BAY 58-2667 Protects against Morbidity and Mortality in Endotoxic Shock by Recoupling Organ Systems

(2013) Benjamin Vandendriessche et al.   PLoS One

A Unified Theory of Sepsis-Induced Acute Kidney Injury

(2013) Hernando Gomez et al.   SHOCK

N-acetylcysteine prevents pulmonary edema and acute kidney injury in rats with sepsis submitted to mechanical ventilation

(2012) Renata Campos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sepsis-induced urinary concentration defect is related to nitric oxide–dependent inactivation of TonEBP/NFAT5, which downregulates renal medullary solute transport proteins and aquaporin-2*

(2012) Christoph Küper et al.   CRITICAL CARE MEDICINE

Acute kidney injury with sepsis

(2012) Robert J. Anderson   CRITICAL CARE MEDICINE

Effect of selective inhibition of renal inducible nitric oxide synthase on renal blood flow and function in experimental hyperdynamic sepsis*

(2012) Ken Ishikawa et al.   CRITICAL CARE MEDICINE

ROLE OF PEROXYNITRITE IN SEPSIS-INDUCED ACUTE KIDNEY INJURY IN AN EXPERIMENTAL MODEL OF SEPSIS IN RATS

(2012) Mariana Seija et al.   SHOCK

Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction

(2011) R Sordi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury

(2011) Joseph H. Holthoff et al.   KIDNEY INTERNATIONAL

Effects of combined arginine vasopressin and levosimendan on organ function in ovine septic shock*

(2010) Sebastian Rehberg et al.   CRITICAL CARE MEDICINE

Differential Involvement of Potassium Channel Subtypes in Early and Late Sepsis-induced Hyporesponsiveness to Vasoconstrictors

(2010) Regina Sordi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Reduced Production of Creatinine Limits Its Use as Marker of Kidney Injury in Sepsis

(2009) K. Doi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acute Kidney Injury Associates with Increased Long-Term Mortality

(2009) J.-P. Lafrance et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury

(2009) Suzanne Heemskerk et al.   Nature Reviews Nephrology

Molecular biology of inflammation and sepsis: A primer*

(2008) Ismail Cinel et al.   CRITICAL CARE MEDICINE

Late, but Not Early, Inhibition of Soluble Guanylate Cyclase Decreases Mortality in a Rat Sepsis Model

(2008) D. Fernandes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NITRIC OXIDE AND VASCULAR REACTIVITY IN SEPSIS

(2008) Daniel Fernandes et al.   SHOCK

Host–pathogen interactions in sepsis

(2007) Tom van der Poll et al.   LANCET INFECTIOUS DISEASES