Article
Biochemistry & Molecular Biology
Emel Erdem Kis, R. Nalan Tiftik, Khairat Al Hennawi, Ismail Un
Summary: This study aimed to investigate the effects of potassium channel blockers on the proliferation and migration of endometrial cancer HEC1-A cells. The results showed that glibenclamide and 4-aminopyridine can reduce cell proliferation and migration, tetraethylammonium only reduces cell proliferation, and potassium chloride only reduces cell migration.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Critical Care Medicine
John A. Kellum, Claudio Ronco
Summary: Septic shock, caused by bacterial toxins like endotoxin, is a severe disease that can lead to organ failure. It is important to note that endotoxin may play a role in all types of septic shock, including non-bacterial causes such as COVID-19. Diagnosis relies on measuring endotoxin activity in addition to clinical assessment. Treatment options are limited, with immune modulating therapies and extracorporeal blood purification still being investigated.
Article
Infectious Diseases
Pedro Martinez-Paz, Marta Aragon-Camino, Esther Gomez-Sanchez, Mario Lorenzo-Lopez, Estefania Gomez-Pesquera, Alejandra Fadrique-Fuentes, Pilar Liu, Alvaro Tamayo-Velasco, Christian Ortega-Loubon, Marta Martin-Fernandez, Hugo Gonzalo-Benito, Emilio Garcia-Moran, Maria Heredia-Rodriguez, Eduardo Tamayo
Summary: The study aims to distinguish between septic shock and non-septic shock in postoperative patients through gene expression signature, providing personalized treatment and avoiding unnecessary antibiotic use and increased healthcare costs.
JOURNAL OF INFECTION
(2021)
Article
Chemistry, Physical
Catarina F. Araujo, Paulo Ribeiro-Claro, Pedro D. Vaz, Svemir Rudic, Rafael A. F. Serrano, Liliana P. Silva, J. A. P. Coutinho, Mariela M. Nolasco
Summary: This study investigates the behavior of deep eutectic solvents (DES) using inelastic neutron scattering (INS) spectroscopy. By calculating the vibrational modes of pure compounds and analyzing the spectra of binary mixtures, deviations from ideality in the mixtures of tetraalkylammonium salts with urea are observed. Unlike other systems, the deviation from ideality in the deep eutectic system comprised of [N2,2,2,1]Cl and urea is attributed to entropic rather than enthalpic factors.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Critical Care Medicine
Alexandria C. Rydz, Jessica L. Elefritz, Megan Conroy, Kathryn A. Disney, Christopher J. Miller, Kyle Porter, Bruce A. Doepker
Summary: The study suggests that early initiation of vasopressin in septic shock may reduce the risk of in-hospital all-cause mortality and/or organ dysfunction.
Letter
Medicine, General & Internal
Azib S. Shahid, Philip Fanapour, Raul J. Gazmuri
Summary: The CLASSIC trial found similar death rates at 90 days in patients with septic shock who received resuscitation with a restrictive-fluid strategy and a liberal-fluid approach.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Debra M. Foster, John A. Kellum
Summary: Endotoxin, also known as lipopolysaccharide (LPS), induces inflammatory response and can lead to sepsis and septic shock. Quantifying endotoxin and removing it using extracorporeal methods may be beneficial for patients with endotoxic septic shock.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Steffen Mitzner, Klaus Kogelmann, Can Ince, Zsolt Molnar, Ricard Ferrer, Axel Nierhaus
Summary: A dysregulated host response is a common feature in critically ill patients and can lead to life-threatening organ dysfunction. Current approved therapies are lacking in modulating excessive immune response, leading to research on blood purification therapies for removing inflammatory mediators. A promising hemoadsorption device (CytoSorb®) has shown positive results in treating patients with hyperinflammation, but further research is needed to address important remaining questions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Federico Carbone, Luca Liberale, Alberto Preda, Thomas Hellmut Schindler, Fabrizio Montecucco
Summary: The onset of cardiomyopathy in sepsis is a common feature that affects its pathophysiology and clinical care. However, there is a lack of consensus in the definition of sepsis-induced cardiomyopathy, and the wide range of ultrasonographic findings may not fully reflect the understanding of the condition. This review explores the current state of research on sepsis-related cardiomyopathy, highlighting the shortcomings in its definition and discussing the dynamic changes in cardiac performance in response to different hemodynamic clusters. The review also addresses the molecular mechanisms leading to myocardial dysfunction and their similarities to myocardial hibernation.
Article
Endocrinology & Metabolism
Ning Ma, Weidong Wu
Summary: This study investigated the transcriptomic responses to septic shock and cardiogenic shock and identified differentially expressed genes and related molecular mechanisms. A total of 28 genes were found to be differentially expressed in both types of shock, and specific genes associated with septic shock were identified. The study provides a basis for distinguishing between septic shock and cardiogenic shock, improving diagnosis and guiding treatment choices.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Critical Care Medicine
Jayshil J. Patel, Rodney Willoughby, Jennifer Peterson, Thomas Carver, James Zelten, Adrienne Markiewicz, Kaitlin Spiegelhoff, Lauren A. Hipp, Bethany Canales, Aniko Szabo, Daren K. Heyland, Christian Stoppe, Jacek Zielonka, Julie K. Freed
Summary: This study examined the feasibility of using high-dose IV hydroxocobalamin compared to placebo in patients with septic shock. The results showed that the high-dose IV hydroxocobalamin group had a greater reduction in vasopressor dose after randomization and infusion, and there were no serious adverse events. This is the first proof of concept for the feasibility of delivering high-dose IV hydroxocobalamin in septic shock.
Article
Cardiac & Cardiovascular Systems
Tobias Schupp, Jan Forner, Jonas Rusnak, Kathrin Weidner, Sascha Egner-Walter, Marinela Ruka, Jonas Dudda, Schanas Jawhar, Lea Marie Brueck, Floriana Dulatahu, Thomas Bertsch, Julian Mueller, Michael Behnes, Ibrahim Akin
Summary: This study investigated the prognostic impact of preexisting and new-onset atrial fibrillation (AF) on 30-day all-cause mortality in patients with septic or cardiogenic shock. The results showed that neither preexisting AF nor new-onset AF were associated with the risk of 30-day all-cause mortality.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Immunology
Huiming Tang, Shuang Qin, Zhanfei Li, Wei Gao, Manli Tang, Xijie Dong
Summary: This study investigates the early immune system changes in patients with septic shock. A total of 243 patients were included, classified as survivors or nonsurvivors. Tests were performed to examine immune system function. Neutrophil counts, infection biomarkers, and cytokines increased significantly in septic shock patients, while lymphocyte counts, immunoglobulin levels, and complement protein levels decreased. Nonsurvivors had higher levels of certain cytokines but lower levels of immunoglobulins and lymphocyte counts. Low immunoglobulin or complement concentrations and low lymphocyte or CD4+ T cell counts were independent risk factors for mortality.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Daniela Urina Jassir, Antoine H. Chaanine, Sapna Desai, Indranee Rajapreyar, Thierry H. Le Jemtel
Summary: Sepsis is a growing cause of decompensation in chronic heart failure patients, regardless of whether their ejection fraction is reduced or preserved. The combination of sepsis and decompensated heart failure leads to a mixed septic-cardiogenic shock, creating therapeutic dilemmas. Rapid fluid resuscitation is crucial for managing sepsis, while loop diuretics are the main treatment for decompensated heart failure. The effectiveness of inotropic therapy with dobutamine or inodilators in improving microvascular alterations in sepsis remains unclear. The timing for reintroducing loop diuretics in sepsis patients with decompensated heart failure is also uncertain. Due to the lack of guidelines, this review focuses on vasopressor therapy, the timing and volume of fluid resuscitation, and the need for inotropic therapy in patients presenting with a mixed septic-cardiogenic shock.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Tie-Ning Zhang, Peng-Hui Hao, Shan-Yan Gao, Chun-Feng Liu, Ni Yang
Summary: This study found that pre-vasopressor shock index (SI), modified SI (MSI), and diastolic SI (DSI) values can effectively predict early mortality risk in patients with septic shock requiring vasopressors. Among these values, SI and MSI showed better predictive performance.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Immunology
Philipe Costa, Lincon Bordignon Somensi, Rita de Cassia Melo Vilhena de Andrade Fonseca da Silva, Luisa Nathalia Bolda Mariano, Thaise Boeing, Bruna Longo, Ellen Perfoll, Priscila de Souza, Lucas Fernando Sergio Gushiken, Claudia Helena Pellizzon, Debora Munhoz Rodrigues, Jairo Kenupp Bastos, Sergio Faloni de Andrade, Luisa Mota Silva
INFLAMMOPHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Thaise Boeing, Priscila De Souza, Silvia Speca, Lincon Bordignon Somensi, Luisa Nathalia Bolda Mariano, Benhur Judah Cury, Mariana Ferreira dos Anjos, Nara Lins Meira Quintao, Laurent Dubuqoy, Pierre Desreumax, Luisa Mota Da Silva, Sergio Faloni De Andrade
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Lincon Bordignon Somensi, Philipe Costa, Thaise Boeing, Luisa Nathalia Bolda Mariano, Bruna Longo, Cassia Goncalves Magalhaes, Lucenir Pain Duarte, Aline Teixeira Maciel e Silva, Priscila de Souza, Sergio Faloni de Andrade, Luisa Mota da Silva
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Article
Pharmacology & Pharmacy
Thaise Boeing, Philipe Costa, Larissa Venzon, Mariane Meurer, Luisa Nathalia Bolda Mariano, Tauani Caroline Santos Franca, Luana Gouveia, Anny Caroline de Bassi, Viviane Steimbach, Priscila de Souza, Marilia Oliveira de Almeida, Caroline Arruda, Sergio Faloni de Andrade, Jairo Kenupp Bastos, Luisa Mota da Silva
Summary: p-Coumaric acid showed beneficial effects in reducing acetic acid-induced gastric ulcer by increasing mucin and reduced glutathione levels, decreasing lipid hydroperoxides, and increasing superoxide dismutase and catalase activities. It also accelerated cell monolayer restructuring during healing process without toxicity to fibroblast cells, but reduced viability in human gastric adenocarcinoma cells.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Marieli Mees, Marianne Caroline Meurer, Luisa Nathalia Bolda Mariano, Thaise Boeing, Lincon Bordignon Somensi, Mariha Mariott, Rivaldo Niero, Valdir Cechinel-Filho, Sergio Faloni de Andrade, Lucienir Pains Duarte, Grasiely Faria de Sousa, Priscila de Souza, Luisa Mota Da Silva
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Review
Plant Sciences
Priscila de Souza, Luisa Nathalia Bolda Mariano, Camile Cecconi Cechinel-Zanchett, Valdir Cechinel-Filho
Summary: Medicinal plants have been used in traditional medicine in Brazil for generations, with many species showing potential as diuretics. While some plants have scientific studies supporting their efficacy, others lack experimental validation. Further research efforts should focus on exploring the untapped potential of Brazilian plants for diuretic purposes.
Article
Biochemistry & Molecular Biology
Bruna Longo, Ellen Perfoll Sommerfeld, Rita de Cassia Melo Vilhena de Andrade Fonseca da Silva, Lincon Bordignon Somensi, Luisa Nathalia Bolda Mariano, Thaise Boeing, Sergio Faloni de Andrade, Priscila de Souza, Luisa Mota da Silva
Summary: This study found that eugenol can accelerate gastric healing process in rats at appropriate doses, showing potential antiulcer effects. However, high doses of eugenol may worsen gastric ulcers.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Integrative & Complementary Medicine
Waqas Younis, Alamgeer, V. B. Schini-Kerth, Samara Requena Nocchi, Denise Brentan Silva, Priscila de Souza, Ishfaq Ali Bukhari, Fahim Vohra, Sibtain Afzal, Arquimedes Gasparotto Junior
Summary: The study evaluated the mechanisms of action of extracts from Asphodelus tenuifolius seeds on blood pressure and diuresis, finding that the aqueous extract produced the most significant hypotensive and diuretic effects in normotensive rats, potentially through activation of muscarinic receptors.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Claudio H. da Silva, Rhanany A. Palozi, Priscila de Souza, Camila L. de Almeida, Valdir Cechinel-Filho, Emerson L. Lourenco, Arquimedes Gasparotto Jr
MINERVA CARDIOANGIOLOGICA
(2020)
Review
Integrative & Complementary Medicine
Thaise Boeing, Karyne Garcia Tafarelo Moreno, Arquimedes Gasparotto Junior, Luisa Mota da Silva, Priscila de Souza
Summary: Equisetum genus, widely distributed globally, is often used in traditional medicine for its diuretic effects and treatment of genitourinary diseases. Particularly, E. arvense and E. bogotense have been studied for their therapeutic potential in inducing diuresis.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Plant Sciences
Thaise Boeing, Jennyfer Andrea Aldana Mejia, Gari Vidal Ccana-Ccapatinta, Marih Mariott, Rita de Cassia Melo Vilhena de Andrade Fonseca Da Silva, Priscila de Souza, Luisa Nathalia Bolda Mariano, Graziela Regina Oliveira, Isabelle Moraes da Rocha, Gabriela Altini da Costa, Sergio Faloni de Andrade, Luisa Mota da Silva, Jairo Kenupp Bastos
Summary: The study evaluated the gastroprotective effect of red propolis, revealing its protective mechanism against ethanol/HCl-induced gastric ulcers, and confirming the important role of MV and MD compounds in its activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Peripheral Vascular Disease
Leonardo Gomes-Pereira, Jose Eduardo da Silva-Santos
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Plant Sciences
Priscila de Souza, Rita de Cassia Vilhena da Silva, Luisa Nathalia Bolda Mariano, Sabrina Lucietti Dick, Giovana Cardozo Ventura, Valdir Cechinel-Filho
Summary: Hesperidin, a flavanone glycoside found in citrus fruits, has been found to have various pharmacological activities, including antihypertensive effects and tissue protection. However, its effect on renal function has not been properly studied.
Article
Oncology
Thaise Boeing, Marcelo Biondaro Gois, Priscila de Souza, Lincon Bordignon Somensi, Debora de Mello Goncales SantAna, Luisa Mota da Silva
Summary: The study aimed to evaluate histopathological changes during irinotecan-induced intestinal mucositis, finding significant alterations in the tissue analysis, which contribute to establishing criteria for assessing histopathological changes and facilitating inter-study comparisons.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Jeniffer Cristovao Moser, Camile Cecconi Cechinel-Zanchett, Luisa Nathalia Bolda Mariano, Thaise Boeing, Luisa Mota da Silva, Priscila de Souza
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2020)
