Benzyl Isothiocyanate-Induced Cytotoxicity via the Inhibition of Autophagy and Lysosomal Function in AGS Cells

Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review

(2021) Thao Nhu Dinh et al.   PHARMACOLOGICAL RESEARCH

Lysosome biology in autophagy

(2020) Willa Wen-You Yim et al.   Cell Discovery

Lysosomal Dysfunction and Autophagy Blockade Contribute to MDMA-Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells

(2020) I-Hsun Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The interrupted effect of autophagic flux and lysosomal function induced by graphene oxide in p62-dependent apoptosis of F98 cells

(2020) Chao Zhang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Autophagy Regulation by the Translation Machinery and Its Implications in Cancer

(2020) Pilar Sarah Acevo-Rodríguez et al.   Frontiers in Oncology

Autophagy as a decisive process for cell death

(2020) Seonghee Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Gastric cancer

(2020) Elizabeth C Smyth et al.   LANCET

Benzyl Isothiocyanate Ameliorates High-Fat Diet-Induced Hyperglycemia by Enhancing Nrf2-Dependent Antioxidant Defense-Mediated IRS-1/AKT/TBC1D1 Signaling and GLUT4 Expression in Skeletal Muscle

(2020) Wei-Ting Chuang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antibacterial activity and main action pathway of benzyl isothiocyanate extracted from papaya seeds

(2020) Ping Li et al.   JOURNAL OF FOOD SCIENCE

Regulation of LC3 Lipidation by the Autophagy-Specific Class III Phosphatidylinostitol-3 Kinase Complex

(2019) Livia W. Brier et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

The Emerging Roles of mTORC1 in Macromanaging Autophagy

(2019) Akpedje S. Dossou et al.   Cancers

Autophagy: A novel mechanism of chemoresistance in cancers

(2019) Xinyu Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition of ULK1 and Beclin1 by an α-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication

(2019) Rosa M. Rubio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers via ryanodine receptor and Ca2+-dependent mechanism

(2019) Betty Yuen Kwan Law et al.   Scientific Reports

Benzyl Isothiocyanate Induces Apoptosis via Reactive Oxygen Species-Initiated Mitochondrial Dysfunction and DR4 and DR5 Death Receptor Activation in Gastric Adenocarcinoma Cells

(2019) Khin Wah Wah Han et al.   Biomolecules

Targeting autophagy for the treatment of cancer

(2018) Simone Fulda   BIOLOGICAL CHEMISTRY

Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo

(2018) Yi-Shih Ma et al.   ENVIRONMENTAL TOXICOLOGY

Inhibition of autophagy promotes cisplatin-induced apoptotic cell death through Atg5 and Beclin 1 in A549 human lung cancer cells

(2018) Jianhua Chen et al.   Molecular Medicine Reports

Aleuritolic Acid Impaired Autophagic Flux and Induced Apoptosis in Hepatocellular Carcinoma HepG2 Cells

(2018) Hua Yi et al.   MOLECULES

Lysosomal membrane permeabilization and cell death

(2018) Fengjuan Wang et al.   TRAFFIC

Autophagy and its role in gastric cancer

(2018) Yijing Cao et al.   CLINICA CHIMICA ACTA

Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion in vitro

(2017) Kuang-Chi Lai et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Dual role of autophagy in hallmarks of cancer

(2017) Shikha Satendra Singh et al.   ONCOGENE

Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress

(2017) Hongyan Zhao et al.   Biology Open

Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms

(2017) Vincent Kam Wai Wong et al.   Frontiers in Pharmacology

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

(2017) Haley R. Pugsley   Jove-Journal of Visualized Experiments

Benzyl isothiocyanate promotes apoptosis of oral cancer cells via an acute redox stress-mediated DNA damage response

(2016) Yao-Tsung Yeh et al.   FOOD AND CHEMICAL TOXICOLOGY

Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate

(2016) Anuradha Sehrawat et al.   MITOCHONDRION

Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells

(2016) NOU-YING TANG et al.   ONCOLOGY REPORTS

Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

(2016) Stjepko Cermak et al.   PLoS One

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

Cathepsin Inhibition-Induced Lysosomal Dysfunction Enhances Pancreatic Beta-Cell Apoptosis in High Glucose

(2015) Minjeong Jung et al.   PLoS One

Modulation of autophagy and its potential for cancer therapy

(2014) S. Claerhout et al.   DRUGS OF THE FUTURE

Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

(2014) Benoit Pasquier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Class III PI3K Vps34: essential roles in autophagy, endocytosis, and heart and liver function

(2013) Nadia Jaber et al.   Annals of the New York Academy of Sciences

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibitory Effect of Benzyl Isothiocyanate on Proliferation in vitro of Human Glioma Cells

(2013) Yu Zhu et al.   Asian Pacific Journal of Cancer Prevention

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Benzyl isothiocyanate induces protective autophagy in human prostate cancer cells via inhibition of mTOR signaling

(2012) Ji-Fan Lin et al.   CARCINOGENESIS

Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research

(2012) S. V. Singh et al.   CARCINOGENESIS

Benzyl Isothiocyanate Causes FoxO1-Mediated Autophagic Death in Human Breast Cancer Cells

(2012) Dong Xiao et al.   PLoS One

Pancreatic Tumor Suppression by Benzyl Isothiocyanate Is Associated with Inhibition of PI3K/AKT/FOXO Pathway

(2011) S. R. Boreddy et al.   CLINICAL CANCER RESEARCH

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

(2010) Kevin Dalby et al.   Autophagy

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Targeting the autophagy pathway for cancer chemoprevention

(2010) Meredith A Steeves et al.   CURRENT OPINION IN CELL BIOLOGY

Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways

(2010) Chin-Chin Ho et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Benzyl Isothiocyanate (BITC) Inhibits Migration and Invasion of Human Colon Cancer HT29 Cells by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase Plasminogen (uPA) through PKC and MAPK Signaling Pathway

(2010) Kuang-Chi Lai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Isothiocyanates, glutathioneS-transferase M1 and T1 polymorphisms and gastric cancer risk: A prospective study of men in Shanghai, China

(2009) Kristin A. Moy et al.   INTERNATIONAL JOURNAL OF CANCER

Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux

(2009) M. Rossi et al.   JOURNAL OF CELL SCIENCE

Benzyl isothiocyanate exhibits anti-inflammatory effects in murine macrophages and in mouse skin

(2009) Yeo Myeong Lee et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells

(2009) R Kar et al.   ONCOGENE