Advanced nanomedicines for the regulation of cancer metabolism

Urchin-Shaped Metal Organic/Hydrogen-Bonded Framework Nanocomposite as a Multifunctional Nanoreactor for Catalysis-Enhanced Synergetic Therapy

(2021) Chunling Hu et al.   ACS Applied Materials & Interfaces

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

(2021) Lian‐Hua Fu et al.   ADVANCED MATERIALS

Polyprodrug with Glutathione Depletion and Cascade Drug Activation for Multi-drug Resistance Reversal

(2021) Xuan Xiao et al.   BIOMATERIALS

Nanosac, a Noncationic and Soft Polyphenol Nanocapsule, Enables Systemic Delivery of siRNA to Solid Tumors

(2021) Hyungjun Kim et al.   ACS Nano

Ultrasmall Alloy Nanozyme for Ultrasound- and Near-Infrared Light-Promoted Tumor Ablation

(2021) Deblin Jana et al.   ACS Nano

Metabolic Control by Heat Stress Determining Cell Fate to Ferroptosis for Effective Cancer Therapy

(2021) Shaowei Xie et al.   ACS Nano

Synchronization of Nanoparticle Sensitization and Radiosensitizing Chemotherapy through Cell Cycle Arrest Achieving Ultralow X-ray Dose Delivery to Pancreatic Tumors

(2021) Divinah Manoharan et al.   ACS Nano

Tailoring Supramolecular Prodrug Nanoassemblies for Reactive Nitrogen Species-Potentiated Chemotherapy of Liver Cancer

(2021) Yongyan Deng et al.   ACS Nano

Engineering a Hydrogen‐Sulfide‐Based Nanomodulator to Normalize Hyperactive Photothermal Immunogenicity for Combination Cancer Therapy

(2021) Jie Li et al.   ADVANCED MATERIALS

Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy

(2021) Mengyu Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-density lipoprotein modulates tumor-associated macrophage for chemoimmunotherapy of hepatocellular carcinoma

(2021) Junyang Wang et al.   Nano Today

A Robust Narrow Bandgap Vanadium Tetrasulfide Sonosensitizer Optimized by Charge Separation Engineering for Enhanced Sonodynamic Cancer Therapy

(2021) Shuang Liang et al.   ADVANCED MATERIALS

Acidity‐Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

(2021) Rundi Song et al.   ADVANCED MATERIALS

Triple‐Jump Photodynamic Theranostics: MnO 2 Combined Upconversion Nanoplatforms Involving a Type‐I Photosensitizer with Aggregation‐Induced Emission Characteristics for Potent Cancer Treatment

(2021) Yuanwei Wang et al.   ADVANCED MATERIALS

A Biomimetic Aggregation‐Induced Emission Photosensitizer with Antigen‐Presenting and Hitchhiking Function for Lipid Droplet Targeted Photodynamic Immunotherapy

(2021) Xiuli Xu et al.   ADVANCED MATERIALS

Biomimetic nanoreactor for targeted cancer starvation therapy and cascade amplificated chemotherapy

(2021) Fengying Shao et al.   BIOMATERIALS

Highly Stable Silica-Coated Bismuth Nanoparticles Deliver Tumor Microenvironment-Responsive Prodrugs to Enhance Tumor-Specific Photoradiotherapy

(2021) Huandong Xiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ultrahigh Sensitive and Tumor-Specific Photoacoustography in NIR-II Region: Optical Writing and Redox-Responsive Graphic Fixing by AgBr@PLGA Nanocrystals

(2021) Dandan Cui et al.   NANO LETTERS

Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

(2021) Yao-Xin Lin et al.   Science Translational Medicine

Chemotherapy-enabled/augmented cascade catalytic tumor-oxidative nanotherapy

(2021) Huijing Xiang et al.   BIOMATERIALS

Hollow Porous Carbon Coated FeS2-Based Nanocatalysts for Multimodal Imaging-Guided Photothermal, Starvation, and Triple-Enhanced Chemodynamic Therapy of Cancer

(2020) Fan Wu et al.   ACS Applied Materials & Interfaces

Co–Ferrocene MOF/Glucose Oxidase as Cascade Nanozyme for Effective Tumor Therapy

(2020) Chao Fang et al.   ADVANCED FUNCTIONAL MATERIALS

Enzyme-Mediated Tumor Starvation and Phototherapy Enhance Mild-Temperature Photothermal Therapy

(2020) Ge Gao et al.   ADVANCED FUNCTIONAL MATERIALS

Light-activated oxygen self-supplied starving therapy in near-infrared (NIR) window and adjuvant hyperthermia-induced tumor ablation with an augmented sensitivity

(2020) Junjie Ren et al.   BIOMATERIALS

GSH-triggered sequential catalysis for tumor imaging and eradication based on star-like Au/Pt enzyme carrier system

(2020) Amin Zhang et al.   Nano Research

Programmable starving-photodynamic synergistic cancer therapy

(2020) Leli Zeng et al.   Science China-Materials

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H 2 O 2 ‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

(2020) Jinping Wang et al.   ADVANCED MATERIALS

Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator

(2020) Yu-Jing He et al.   BIOMATERIALS

Gold-Based Nanoparticles on Amino-Functionalized Mesoporous Silica Supports as Nanozymes for Glucose Oxidation

(2020) M. Carmen Ortega-Liebana et al.   Catalysts

H2 O2 -responsive Nanogel for Enhancing Chemodynamic Therapy

(2020) Yuling Yang et al.   ChemNanoMat

Metabolic Modulation of the Tumor Microenvironment Leads to Multiple Checkpoint Inhibition and Immune Cell Infiltration

(2020) David Kolb et al.   ACS Nano

A Tumor-Targeted Cascade Nanoreactor Based on Metal-Organic-Frameworks for Synergistic Ferroptosis−Starvation Anticancer Therapy

(2020) Xiuyan Wan et al.   ACS Nano

Intervening Tumor Progression by Coupling Bacteria Respiration with Tumor Metabolism

(2020) Qi-Wen Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

pH-Responsive Cascaded Nanocatalyst for Synergistic Like-Starvation and Chemodynamic therapy

(2020) Yameng Wang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Nano-sized metal-organic frameworks: Synthesis and applications

(2020) Xuechao Cai et al.   COORDINATION CHEMISTRY REVIEWS

NIR-II driven plasmon-enhanced cascade reaction for tumor microenvironment-regulated catalytic therapy based on bio-breakable Au–Ag nanozyme

(2020) Min Xu et al.   Nano Research

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

(2020) Haozhe He et al.   Small

Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment

(2020) Tao Zheng et al.   Nano-Micro Letters

Biocatalysis of MnO2-mediated Nanosystem for Enhanced Multimodal Therapy and Real-time Tracking

(2020) Xiaowei Li et al.   ACS Sustainable Chemistry & Engineering

Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma

(2020) Yunfeng Gao et al.   Nature Biomedical Engineering

Glioblastoma Therapy Using Codelivery of Cisplatin and Glutathione Peroxidase Targeting siRNA from Iron Oxide Nanoparticles

(2020) Yulin Zhang et al.   ACS Applied Materials & Interfaces

Surface-Charge-Switchable Nanoclusters for Magnetic Resonance Imaging-Guided and Glutathione Depletion-Enhanced Photodynamic Therapy

(2020) Jianzhi Zhu et al.   ACS Nano

Metal–Organic Framework Derived Multicomponent Nanoagent as a Reactive Oxygen Species Amplifier for Enhanced Photodynamic Therapy

(2020) Dongdong Wang et al.   ACS Nano

Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery

(2020) Binfan Chen et al.   BIOMATERIALS

Biodegradable Poly(γ-glutamic acid)@glucose oxidase@carbon dot nanoparticles for simultaneous multimodal imaging and synergetic cancer therapy

(2020) Ming Zhang et al.   BIOMATERIALS

A Sequential-Catalytic, Magnetic Targeting Nanoplatform for Synergistic Photothermal and NIR-Enhanced Chemodynamic Therapy

(2020) Shuming Dong et al.   CHEMISTRY OF MATERIALS

The self-assembled α-lactalbumin-oleic acid complex inhibits ATP supply from both glycolysis and the TCA cycle in HepG2 cells and HepG2-bearing nude mice

(2020) Bing Fang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

ATP-responsive hollow nanocapsules for DOX/GOx delivery to enable tumor inhibition with suppressed P-glycoprotein

(2020) Huimin Zhu et al.   Nano Research

GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer

(2020) Zhanwei Zhou et al.   Science Advances

Photogenerated Holes Mediated Nitric Oxide Production for Hypoxic Tumor Treatment

(2020) Xiao Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy

(2020) Yuanyuan Yang et al.   BIOMATERIALS

An urchin-like helical polypeptide-asparaginase conjugate with mitigated immunogenicity

(2020) Yali Hu et al.   BIOMATERIALS

Nanoreactor of “butterfly effect” inciting a triple interlocked combination of starvation/chemo/metal ion therapy by remodeling tumor microenvironment

(2020) Zining Hao et al.   CHEMICAL ENGINEERING JOURNAL

pH-Responsive Oxygen Nanobubbles for Spontaneous Oxygen Delivery in Hypoxic Tumors

(2019) Ruyuan Song et al.   LANGMUIR

A biomimetic cascade nanoreactor for tumor targeted starvation therapy-amplified chemotherapy

(2019) Hong Cheng et al.   BIOMATERIALS

Tailoring Nanomaterials for Targeting Tumor‐Associated Macrophages

(2019) Muhammad Ovais et al.   ADVANCED MATERIALS

Cancer Cell Membrane Camouflaged Nanoparticles to Realize Starvation Therapy Together with Checkpoint Blockades for Enhancing Cancer Therapy

(2019) Wei Xie et al.   ACS Nano

In Situ Oxygenic Nanopods Targeting Tumor Adaption to Hypoxia Potentiate Image-Guided Photothermal Therapy

(2019) Vishnu Revuri et al.   ACS Applied Materials & Interfaces

Promoting Oxidative Stress in Cancer Starvation Therapy by Site-Specific Startup of Hyaluronic Acid-Enveloped Dual-Catalytic Nanoreactors

(2019) Zhigang Yao et al.   ACS Applied Materials & Interfaces

Ultrasmall Oxygen‐Deficient Bimetallic Oxide MnWO X Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy

(2019) Fei Gong et al.   ADVANCED MATERIALS

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy

(2019) Yu-Xue Zhang et al.   NANO LETTERS

Mild Hyperthermia-Enhanced Enzyme-Mediated Tumor Cell Chemodynamic Therapy

(2019) Xinhe Liu et al.   ACS Applied Materials & Interfaces

Positive feedback nanoamplifier responded to tumor microenvironments for self-enhanced tumor imaging and therapy

(2019) Ying Zhang et al.   BIOMATERIALS

Cascade-Reaction-Based Nanodrug for Combined Chemo/Starvation/Chemodynamic Therapy against Multidrug-Resistant Tumors

(2019) Ying Chen et al.   ACS Applied Materials & Interfaces

Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity

(2019) Ying Xu et al.   ACS Nano

Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

(2019) Fan Gao et al.   ADVANCED MATERIALS

Photo-controlled liquid metal nanoparticle-enzyme for starvation/photothermal therapy of tumor by win-win cooperation

(2019) Jing-Jing Hu et al.   BIOMATERIALS

Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

(2019) Xuan Meng et al.   NANO LETTERS

Nanomedicines Lost in Translation

(2019) Keegan Guidolin et al.   ACS Nano

Biodegradable Manganese-Doped Calcium Phosphate Nanotheranostics for Traceable Cascade Reaction-Enhanced Anti-Tumor Therapy

(2019) Lian-Hua Fu et al.   ACS Nano

Multivalency-assisted membrane-penetrating siRNA delivery sensitizes photothermal ablation via inhibition of tumor glycolysis metabolism

(2019) Juanjuan Dang et al.   BIOMATERIALS

MnO2 Motor: A Prospective Cancer-Starving Therapy Promoter

(2018) Yao-Hui Zhang et al.   ACS Applied Materials & Interfaces

Glutathione-Depleting Gold Nanoclusters for Enhanced Cancer Radiotherapy through Synergistic External and Internal Regulations

(2018) Xiaodong Zhang et al.   ACS Applied Materials & Interfaces

Engineering of a Nanosized Biocatalyst for Combined Tumor Starvation and Low-Temperature Photothermal Therapy

(2018) Jun Zhou et al.   ACS Nano

A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver

(2018) Jianming Liang et al.   Nano Research

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Erythrocyte Membrane Cloaked Metal-Organic Framework Nanoparticle as Biomimetic Nanoreactor for Starvation-Activated Colon Cancer Therapy

(2018) Lu Zhang et al.   ACS Nano

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction

(2018) Zhongmin Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glutamine addiction activates polyglutamine-based nanocarriers delivering therapeutic siRNAs to orthotopic lung tumor mediated by glutamine transporter SLC1A5

(2018) Cuifeng Wang et al.   BIOMATERIALS

Mesoporous Metal-Organic Frameworks: Synthetic Strategies and Emerging Applications

(2018) Dingxin Liu et al.   Small

Lipid-Polymer Bilaminar Oxygen Nanobubbles for Enhanced Photodynamic Therapy of Cancer

(2018) Ruyuan Song et al.   ACS Applied Materials & Interfaces

An Adenosine Triphosphate-Responsive Autocatalytic Fenton Nanoparticle for Tumor Ablation with Self-Supplied H2O2 and Acceleration of Fe(III)/Fe(II) Conversion

(2018) Lu Zhang et al.   NANO LETTERS

A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis

(2018) Zhengze Yu et al.   Nature Communications

A two-photon excited O2-evolving nanocomposite for efficient photodynamic therapy against hypoxic tumor

(2018) Run-Qing Li et al.   BIOMATERIALS

Co-delivery nanocarriers targeting folate receptor and encapsulating 2-deoxyglucose and α-tocopheryl succinate enhance anti-tumor effect in vivo

(2017) Xiaoying Lei et al.   International Journal of Nanomedicine

Metalloporphyrin-Encapsulated Biodegradable Nanosystems for Highly Efficient Magnetic Resonance Imaging-Guided Sonodynamic Cancer Therapy

(2017) Ping Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy

(2017) Chen Zhang et al.   Nature Nanotechnology

Tumor-selective catalytic nanomedicine by nanocatalyst delivery

(2017) Minfeng Huo et al.   Nature Communications

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

(2017) Guangbao Yang et al.   Nature Communications

Carbon-Dot-Decorated Carbon Nitride Nanoparticles for Enhanced Photodynamic Therapy against Hypoxic Tumor via Water Splitting

(2016) Di-Wei Zheng et al.   ACS Nano

Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy

(2016) Guosheng Song et al.   ADVANCED MATERIALS

Glutathione in metastases: From mechanisms to clinical applications

(2016) José M. Estrela et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Highly stable polyglutamate derivatives/siRNA polyplex efficiently down-relegate survivin expression and augment the efficacy of cisplatin

(2016) Zhongjuan Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies

(2016) Xuejiao Song et al.   NANO LETTERS

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

(2015) Wenpei Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Resveratrol-loaded polymeric nanoparticles suppress glucose metabolism and tumor growth in vitro and in vivo

(2015) Kyung-Ho Jung et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

The energy blocker inside the power house: mitochondria targeted delivery of 3-bromopyruvate

(2015) Sean Marrache et al.   Chemical Science

Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death

(2015) Joungyoun Noh et al.   Nature Communications

Functional Manipulation of Dendritic Cells by Photoswitchable Generation of Intracellular Reactive Oxygen Species

(2014) Taek-Chin Cheong et al.   ACS Chemical Biology

Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment

(2014) Vinit Kumar et al.   IMMUNOLOGY

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Engineering an Effective Immune Adjuvant by Designed Control of Shape and Crystallinity of Aluminum Oxyhydroxide Nanoparticles

(2013) Bingbing Sun et al.   ACS Nano

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

(2011) Asis Palazón et al.   CLINICAL CANCER RESEARCH

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Light-controlled nitric oxide delivering molecular assemblies

(2010) Salvatore Sortino   CHEMICAL SOCIETY REVIEWS

Oxidative stress in non-small cell lung cancer patients after chemotherapy: Association with treatment response

(2010) Abhilasha GUPTA et al.   RESPIROLOGY

Reduction-sensitive polymers and bioconjugates for biomedical applications

(2009) Fenghua Meng et al.   BIOMATERIALS

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY