A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets

Diabetes mellitus and melatonin: Where are we?

(2022) Roma Patel et al.   BIOCHIMIE

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

(2020) Courtney Ackeifi et al.   Science Translational Medicine

GLP-1 Analogs and DPP-4 Inhibitors in Type 2 Diabetes Therapy: Review of Head-to-Head Clinical Trials

(2020) Matthew P. Gilbert et al.   Frontiers in Endocrinology

Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks

(2019) Rüdiger Hardeland   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism

(2019) Sharon Owino et al.   Frontiers in Endocrinology

Association of melatonin & MTNR1B variants with type 2 diabetes in Gujarat population

(2018) Roma Patel et al.   BIOMEDICINE & PHARMACOTHERAPY

Challenges in pancreas transplantation

(2016) E. J. Sharples et al.   ACTA DIABETOLOGICA

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

The incretin hormone GLP-1 and mechanisms underlying its secretion

(2016) Lili Tian et al.   Journal of Diabetes

Activation of Melatonin Signaling Promotes β-Cell Survival and Function

(2015) Safia Costes et al.   MOLECULAR ENDOCRINOLOGY

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet

(2015) Petra I. Lorenzo et al.   Scientific Reports

The DPP-4 Inhibitor Linagliptin Restores β-Cell Function and Survival in Human Isolated Islets Through GLP-1 Stabilization

(2013) Payal Shah et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Melatonin prevents pancreaticβ-cell loss due to glucotoxicity: the relationship between oxidative stress and endoplasmic reticulum stress

(2013) Jae-Hyung Park et al.   JOURNAL OF PINEAL RESEARCH

Effects of melatonin on islet neogenesis and beta cell apoptosis in streptozotocin-induced diabetic rats: an immunohistochemical study

(2012) N. Simsek et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Dipeptidyl peptidase-4 inhibitors and preservation of pancreatic islet-cell function: a critical appraisal of the evidence

(2011) R. E. van Genugten et al.   DIABETES OBESITY & METABOLISM

The insulin–melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus)

(2011) E. Peschke et al.   DIABETOLOGIA

Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?

(2011) N M Whalley et al.   JOURNAL OF ENDOCRINOLOGY

Distribution of melatonin receptors in murine pancreatic islets

(2011) Cecilia L. F. Nagorny et al.   JOURNAL OF PINEAL RESEARCH

Neurogenin3: A master regulator of pancreatic islet differentiation and regeneration

(2010) J. Michael Rukstalis et al.   Islets

Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: Interactions With Metformin

(2009) A. V. Matveyenko et al.   DIABETES

Age-Dependent Decline in  -Cell Proliferation Restricts the Capacity of  -Cell Regeneration in Mice

(2009) S.-I. Tschen et al.   DIABETES

C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

(2009) Carlos E. B. Couri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Melatonin prolongs islet graft survival in diabetic NOD mice

(2009) Gu-Jiun Lin et al.   JOURNAL OF PINEAL RESEARCH

Inhibition of Dipeptidyl Peptidase IV With Sitagliptin (MK0431) Prolongs Islet Graft Survival in Streptozotocin-Induced Diabetic Mice

(2008) S.-J. Kim et al.   DIABETES

Dipeptidyl Peptidase IV Inhibition With MK0431 Improves Islet Graft Survival in Diabetic NOD Mice Partially via T-Cell Modulation

(2008) S.-J. Kim et al.   DIABETES

Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic β-cells

(2008) Ina Stumpf et al.   JOURNAL OF PINEAL RESEARCH

Modulation of the cGMP signaling pathway by melatonin in pancreaticβ-cells

(2008) Ina Stumpf et al.   JOURNAL OF PINEAL RESEARCH