Lipid‐Polymer Hybrid “Particle‐in‐Particle” Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID‐19 Vaccines

Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy

(2022) Bin Wang et al.   Bioactive Materials

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

(2021) Jing-Hui Tian et al.   Nature Communications

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

(2021) Shuai Liu et al.   NATURE MATERIALS

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

(2021) Linde Schoenmaker et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Lipids and Lipid Derivatives for RNA Delivery

(2021) Yuebao Zhang et al.   CHEMICAL REVIEWS

Lipid Nanoparticle Spherical Nucleic Acids for Intracellular DNA and RNA Delivery

(2021) Andrew J. Sinegra et al.   NANO LETTERS

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Challenges of Storage and Stability of mRNA-Based COVID-19 Vaccines

(2021) Mohammad N. Uddin et al.   Vaccines

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

A Thermostable mRNA Vaccine against COVID-19

(2020) Na-Na Zhang et al.   CELL

Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities

(2020) Johan Karlsson et al.   Expert Opinion on Drug Delivery

Nanoparticle depots for controlled and sustained gene delivery

(2020) Zhongyu Li et al.   JOURNAL OF CONTROLLED RELEASE

Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy

(2020) Qijing Chen et al.   JOURNAL OF CONTROLLED RELEASE

Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain

(2020) Xue Tian et al.   JOURNAL OF PAIN

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

(2020) Wei Tao et al.   Science Translational Medicine

Long-term storage of lipid-like nanoparticles for mRNA delivery

(2020) Pengxuan Zhao et al.   Bioactive Materials

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge

(2020) Shipo Wu et al.   Nature Communications

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

(2020) Alicia T. Widge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Comparison of Plasmid DNA and mRNA as Vaccine Technologies

(2019) Liu   Vaccines

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

Dopant-Free Hydrogels with Intrinsic Photoluminescence and Biodegradable Properties

(2018) Yung-Hao Tsou et al.   ADVANCED FUNCTIONAL MATERIALS

Optimization of a Degradable Polymer–Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells

(2018) James C. Kaczmarek et al.   NANO LETTERS

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

(2016) Rebecca Ball et al.   International Journal of Nanomedicine

Polymeric Nanoparticles for Nonviral Gene Therapy Extend Brain Tumor Survival in Vivo

(2015) Antonella Mangraviti et al.   ACS Nano

Biodegradable Polymeric Nanoparticles Show High Efficacy and Specificity at DNA Delivery to Human Glioblastoma in Vitro and in Vivo

(2014) Hugo Guerrero-Cázares et al.   ACS Nano

Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability

(2013) Ahmed A. Eltoukhy et al.   ADVANCED MATERIALS

Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug

(2013) X. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Non-viral gene delivery nanoparticles based on Poly(β-amino esters) for treatment of glioblastoma

(2011) Stephany Y. Tzeng et al.   BIOMATERIALS

Long-term stability of sterically stabilized liposomes by freezing and freeze-drying: Effects of cryoprotectants on structure

(2010) Brigitte Stark et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An overview of liposome lyophilization and its future potential

(2009) Chengjun Chen et al.   JOURNAL OF CONTROLLED RELEASE

Short- and long-term stability study of lyophilized solid lipid nanoparticles for gene therapy

(2008) A. del Pozo-Rodríguez et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Comparative study of poly (lactic-co-glycolic acid)-poly ethyleneimine-plasmid DNA microparticles prepared using double emulsion methods

(2008) Xue-Qing Zhang et al.   JOURNAL OF MICROENCAPSULATION