Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy

In situ cancer vaccination using lipidoid nanoparticles

(2021) Jinjin Chen et al.   Science Advances

Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma

(2021) C. Elizabeth Boudreau et al.   CLINICAL CANCER RESEARCH

Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting

(2020) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

(2020) Yutong Zhou et al.   Science Advances

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

Challenges to curing primary brain tumours

(2019) Kenneth Aldape et al.   Nature Reviews Clinical Oncology

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

(2019) Guijun Shang et al.   NATURE

Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice

(2018) Linhao You et al.   ACS Nano

Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma

(2018) Kelong Fan et al.   ACS Nano

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

(2018) Gang Jia et al.   BIOMATERIALS

Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy

(2018) Keman Cheng et al.   NANO LETTERS

STING directly activates autophagy to tune the innate immune response

(2018) Dong Liu et al.   CELL DEATH AND DIFFERENTIATION

Remodeling Tumor-Associated Macrophages and Neovascularization Overcomes EGFRT790M -Associated Drug Resistance by PD-L1 Nanobody-Mediated Codelivery

(2018) Weimin Yin et al.   Small

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Oligonucleotide therapies for disorders of the nervous system

(2017) Olga Khorkova et al.   NATURE BIOTECHNOLOGY

Drug Delivery to the Brain across the Blood-Brain Barrier Using Nanomaterials

(2017) Yung-Hao Tsou et al.   Small

STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation

(2016) Ken Takashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Generation of an in vitro 3D PDAC stroma rich spheroid model

(2016) Matthew J. Ware et al.   BIOMATERIALS

Tumor infiltrating immune cells in gliomas and meningiomas

(2016) Patrícia Domingues et al.   BRAIN BEHAVIOR AND IMMUNITY

CSF, blood-brain barrier, and brain drug delivery

(2016) William M. Pardridge   Expert Opinion on Drug Delivery

Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progression

(2016) Yifeng Lei et al.   JOURNAL OF CONTROLLED RELEASE

Ferritin nanocages: A biological platform for drug delivery, imaging and theranostics in cancer

(2016) Marta Truffi et al.   PHARMACOLOGICAL RESEARCH

Generation of Homogenous Three-Dimensional Pancreatic Cancer Cell Spheroids Using an Improved Hanging Drop Technique

(2016) Matthew J. Ware et al.   TISSUE ENGINEERING PART C-METHODS

Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents

(2016) Julie Gaston et al.   Oncotarget

STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia

(2016) Emily Curran et al.   Cell Reports

Improved Doxorubicin Encapsulation and Pharmacokinetics of Ferritin–Fusion Protein Nanocarriers Bearing Proline, Serine, and Alanine Elements

(2015) Elisabetta Falvo et al.   BIOMACROMOLECULES

Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors

(2015) J. R. Baird et al.   CANCER RESEARCH

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

(2015) Olivier Demaria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection

(2014) M. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory Effect of Neuropilin-1 Monoclonal Antibody (NRP-1 MAb) on Glioma Tumor in Mice

(2013) Lukui Chen et al.   Journal of Biomedical Nanotechnology

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Strategies for advancing cancer nanomedicine

(2013) Vikash P. Chauhan et al.   NATURE MATERIALS

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

pH-Dependent Structures of Ferritin and Apoferritin in Solution: Disassembly and Reassembly

(2011) Mihee Kim et al.   BIOMACROMOLECULES

Self-Assembly in the Ferritin Nano-Cage Protein Superfamily

(2011) Yu Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Grand challenges in global mental health

(2011) Pamela Y. Collins et al.   NATURE

Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma

(2011) L. Agemy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Evaluation of 3 Clinical Dendritic Cell Maturation Protocols Containing Lipopolysaccharide and Interferon-γ

(2009) Tae Hee Han et al.   JOURNAL OF IMMUNOTHERAPY

Development of a novel mouse glioma model using lentiviral vectors

(2009) Tomotoshi Marumoto et al.   NATURE MEDICINE

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA