Trichostatin A, a histone deacetylase inhibitor suppresses NADPH Oxidase 4-Derived Redox Signalling and Angiogenesis

The NADPH Oxidase Nox4 mediates tumour angiogenesis

(2015) V. Helfinger et al.   Acta Physiologica

Histone deacetylases: structural determinants of inhibitor selectivity

(2015) Carmina Micelli et al.   DRUG DISCOVERY TODAY

Histone deacetylases as therapeutic targets — From cancer to cardiac disease

(2015) Alon Abend et al.   PHARMACOLOGY & THERAPEUTICS

NADPH Oxidase 4-Derived H2O2Promotes Aberrant Retinal Neovascularization via Activation of VEGF Receptor 2 Pathway in Oxygen-Induced Retinopathy

(2015) Jingming Li et al.   Journal of Diabetes Research

Prostacyclin Signaling Boosts NADPH Oxidase 4 in the Endothelium Promoting Cytoprotection and Angiogenesis

(2014) Hitesh M. Peshavariya et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidase 4 Is Expressed in Pulmonary Artery Adventitia and Contributes to Hypertensive Vascular Remodeling

(2014) Scott A. Barman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines

(2014) Lili Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NADPH oxidase 4 promotes cardiac microvascular angiogenesis after hypoxia/reoxygenation in vitro

(2014) Jinyi Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β

(2014) Guangxing Bai et al.   GENE

Transforming growth factor-β1 requires NADPH oxidase 4 for angiogenesisin vitroandin vivo

(2014) Hitesh M Peshavariya et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Dexamethasone Upregulates Nox1 Expression in Vascular Smooth Muscle Cells

(2014) Daniel Siuda et al.   PHARMACOLOGY

Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition

(2013) Feng Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells

(2012) Daniel Siuda et al.   BASIC RESEARCH IN CARDIOLOGY

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis

(2011) Stephanie Carnesecchi et al.   ANTIOXIDANTS & REDOX SIGNALING

Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells

(2011) Claudia Goettsch et al.   BASIC RESEARCH IN CARDIOLOGY

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

(2011) Siobhan M. Craige et al.   CIRCULATION

Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene

(2011) Masato Katsuyama et al.   FEBS Journal

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase Inhibitors Impair Antibacterial Defenses of Macrophages

(2011) Matteo Mombelli et al.   JOURNAL OF INFECTIOUS DISEASES

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Histone deacetylases as regulators of inflammation and immunity

(2011) Melanie R. Shakespear et al.   TRENDS IN IMMUNOLOGY

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-α in cerebral vascular endothelial cells

(2009) Shyamali Basuroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

p21 WAF1 negatively regulates DNMT1 expression in mammalian cells

(2009) Hwee Hong Tan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rational Combinations Using HDAC Inhibitors

(2009) M. Bots et al.   CLINICAL CANCER RESEARCH

Histone acetyl transferases as emerging drug targets

(2009) Frank J. Dekker et al.   DRUG DISCOVERY TODAY

N-Hydroxy-7-(2-naphthylthio) Heptanomide Inhibits Retinal and Choroidal Angiogenesis

(2009) Jeong Hun Kim et al.   MOLECULAR PHARMACEUTICS

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival

(2009) Hitesh Peshavariya et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Regulation of cell proliferation by NADPH oxidase-mediated signaling: Potential roles in tissue repair, regenerative medicine and tissue engineering

(2009) Elsa C. Chan et al.   PHARMACOLOGY & THERAPEUTICS

Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

(2008) Srikanth Pendyala et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of p300 Histone Acetyltransferase Activity Is an Early Endothelial Response to Laminar Shear Stress and Is Essential for Stimulation of Endothelial Nitric-oxide Synthase mRNA Transcription

(2008) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY