Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition

Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

(2012) Chinmay Y. Majmudar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1

(2012) C. M. Denis et al.   BLOOD

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

The Targets of Curcumin

(2012) Hongyu Zhou et al.   CURRENT DRUG TARGETS

The bromodomain interaction module

(2012) Panagis Filippakopoulos et al.   FEBS LETTERS

Interactions Between β-Catenin and Transforming Growth Factor-β Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP)

(2012) Beiyun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Analysis of Multisite Protein–Ligand Interactions by NMR: Binding of Intrinsically Disordered p53 Transactivation Subdomains with the TAZ2 Domain of CBP

(2012) Munehito Arai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

(2012) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

(2011) Jagat C. Borah et al.   CHEMISTRY & BIOLOGY

The Gamma Catenin/CBP Complex Maintains Survivin Transcription in β-catenin Deficient/Depleted Cancer Cells

(2011) Y.-M. Kim et al.   CURRENT CANCER DRUG TARGETS

Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation

(2011) Y.-H. Lee et al.   GENES & DEVELOPMENT

Selective Roles for cAMP Response Element-binding Protein Binding Protein and p300 Protein as Coregulators for Androgen-regulated Gene Expression in Advanced Prostate Cancer Cells

(2011) Irina Ianculescu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

(2011) David S. Hewings et al.   JOURNAL OF MEDICINAL CHEMISTRY

HTLV-1 HBZ Protein Deregulates Interactions between Cellular Factors and the KIX Domain of p300/CBP

(2011) Pamela R. Cook et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Peek into the Complex Realm of Histone Phosphorylation

(2011) T. Banerjee et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines

(2011) F. R. Santer et al.   MOLECULAR CANCER THERAPEUTICS

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease

(2011) Rugao Liu et al.   NEUROBIOLOGY OF DISEASE

Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly

(2011) Ju He et al.   NUCLEIC ACIDS RESEARCH

The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor

(2011) V M Renault et al.   ONCOGENE

The PHD Finger of Human UHRF1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers

(2011) Nada Lallous et al.   PLoS One

Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF)

(2011) C. Mas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the p53 Transactivation Domain in Complex with the Nuclear Receptor Coactivator Binding Domain of CREB Binding Protein

(2010) Chul Won Lee et al.   BIOCHEMISTRY

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes

(2010) Jihong Chen et al.   Epigenetics

Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers

(2010) V. Gotea et al.   GENOME RESEARCH

Transcriptional Switches: Chemical Approaches to Gene Regulation

(2010) Lori W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease

(2010) A. Caccamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation

(2010) C. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP

(2010) Magnus Kjaergaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic Interplay between Promoter Recognition and CBP/p300 Coactivator Recruitment by FOXO3a

(2009) Feng Wang et al.   ACS Chemical Biology

Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors

(2009) Sara J. Buhrlage et al.   ACS Chemical Biology

Structure of the Taz2 domain of p300: insights into ligand binding

(2009) Maria Miller et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Two Distinct Motifs within the p53 Transactivation Domain Bind to the Taz2 Domain of p300 and Are Differentially Affected by Phosphorylation†

(2009) Lisa M. Miller Jenkins et al.   BIOCHEMISTRY

Mapping the Interactions of the p53 Transactivation Domain with the KIX Domain of CBP†

(2009) Chul Won Lee et al.   BIOCHEMISTRY

Systematic in vivo structure-function analysis of p300 in hematopoiesis

(2009) E. A. Kimbrel et al.   BLOOD

Discovery of a Small-Molecule Inhibitor of the KIX–KID Interaction

(2009) Bingbing X. Li et al.   CHEMBIOCHEM

Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains

(2009) Jonathan M Wojciak et al.   EMBO JOURNAL

Direct Inhibition of Hypoxia-Inducible Transcription Factor Complex with Designed Dimeric Epidithiodiketopiperazine

(2009) Katherine M. Block et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CBP/p300-mediated acetylation of histone H3 on lysine 56

(2009) Chandrima Das et al.   NATURE

Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2

(2009) D P Teufel et al.   ONCOGENE

Conformational selection or induced fit: A flux description of reaction mechanism

(2009) G. G. Hammes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation

(2009) Hanqiao Feng et al.   STRUCTURE

CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription

(2009) Hiroshi Hosoda et al.   Molecular Brain

Quantitative Control of Adaptive Cardiac Hypertrophy by Acetyltransferase p300

(2008) Jian Qin Wei et al.   CIRCULATION

Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function

(2008) Ling Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mechanism of p300 Specific Histone Acetyltransferase Inhibition by Small Molecules

(2008) M. Arif et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biochemical and Structural Characterization of an Intramolecular Interaction in FOXO3a and Its Binding with p53

(2008) Feng Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Histone Ubiquitination: Triggering Gene Activity

(2008) Vikki M. Weake et al.   MOLECULAR CELL

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

(2008) Xin Liu et al.   NATURE

Structural insights into human KAP1 PHD finger–bromodomain and its role in gene silencing

(2008) Lei Zeng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a)

(2008) B. M. Emerling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300

(2008) Lei Zeng et al.   STRUCTURE

Binding-Induced Folding of a Natively Unstructured Transcription Factor

(2008) Adrian Gustavo Turjanski et al.   PLoS Computational Biology