Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

(2021) Vladan Rankovic et al.   Frontiers in Molecular Neuroscience

Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates

(2021) Gregory Gauvain et al.   Communications Biology

Developing Fast, Red-Light Optogenetic Stimulation of Spiral Ganglion Neurons for Future Optical Cochlear Implants

(2021) Antoine Tarquin Huet et al.   Frontiers in Molecular Neuroscience

Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway

(2021) Burak Bali et al.   EMBO Molecular Medicine

Partial recovery of visual function in a blind patient after optogenetic therapy

(2021) José-Alain Sahel et al.   NATURE MEDICINE

AAV ablates neurogenesis in the adult murine hippocampus

(2021) Stephen Johnston et al.   eLife

Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages

(2020) Chao Li et al.   eLife

Towards the optical cochlear implant: optogenetic approaches for hearing restoration

(2020) Alexander Dieter et al.   EMBO Molecular Medicine

Emerging approaches for restoration of hearing and vision

(2020) Sonja Kleinlogel et al.   PHYSIOLOGICAL REVIEWS

μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve

(2020) Alexander Dieter et al.   EMBO Molecular Medicine

Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents

(2020) Daniel Keppeler et al.   Science Translational Medicine

Hybrid optogenetic and electrical stimulation for greater spatial resolution and temporal fidelity of cochlear activation

(2020) Alex Thompson et al.   Journal of Neural Engineering

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

(2019) Daniel Felsky et al.   Nature Communications

Near physiological spectral selectivity of cochlear optogenetics

(2019) Alexander Dieter et al.   Nature Communications

Recombinant Adeno-Associated Virus Gene Therapy in Light of Luxturna (and Zolgensma and Glybera): Where Are We, and How Did We Get Here?

(2019) Allison M. Keeler et al.   Annual Review of Virology

Dye Tracking Following Posterior Semicircular Canal or Round Window Membrane Injections Suggests a Role for the Cochlea Aqueduct in Modulating Distribution

(2019) Sara Talaei et al.   Frontiers in Cellular Neuroscience

Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery

(2019) Natalie F. Nidetz et al.   PHARMACOLOGY & THERAPEUTICS

Ancestral Adeno-Associated Virus Vector Delivery of Opsins to Spiral Ganglion Neurons: Implications for Optogenetic Cochlear Implants

(2018) Maria J. Duarte et al.   MOLECULAR THERAPY

Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils

(2018) Christian Wrobel et al.   Science Translational Medicine

High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics

(2018) Thomas Mager et al.   Nature Communications

Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System

(2018) Shuohao Sun et al.   CELL

Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity

(2018) Brikha R. Shrestha et al.   CELL

Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system

(2018) Charles Petitpré et al.   Nature Communications

Ultrafast optogenetic stimulation of the auditory pathway by targeting‐optimized Chronos

(2018) Daniel Keppeler et al.   EMBO JOURNAL

A dual‐AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice

(2018) Hanan Al‐Moyed et al.   EMBO Molecular Medicine

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

(2017) Lukas D Landegger et al.   NATURE BIOTECHNOLOGY

T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer’s disease-like cerebral amyloidosis

(2016) M.T. Ferretti et al.   BRAIN BEHAVIOR AND IMMUNITY

Auditory neuropathy — neural and synaptic mechanisms

(2016) Tobias Moser et al.   Nature Reviews Neurology

Optogenetic stimulation of the cochlea—A review of mechanisms, measurements, and first models

(2016) Robin S. Weiss et al.   NETWORK-COMPUTATION IN NEURAL SYSTEMS

Disruption of adaptor protein 2  (AP-2 ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing

(2015) S. Jung et al.   EMBO JOURNAL

Local and systemic responses following intravitreous injection of AAV2-encoded modified Volvox channelrhodopsin-1 in a genetically blind rat model

(2015) E Sugano et al.   GENE THERAPY

Considering optogenetic stimulation for cochlear implants

(2015) Marcus Jeschke et al.   HEARING RESEARCH

Tmc gene therapy restores auditory function in deaf mice

(2015) Charles Askew et al.   Science Translational Medicine

Optogenetic stimulation of the auditory pathway

(2014) Victor H. Hernandez et al.   JOURNAL OF CLINICAL INVESTIGATION

Histological Quantitation of Brain Injury Using Whole Slide Imaging: A Pilot Validation Study in Mice

(2014) Zhenzhou Chen et al.   PLoS One

Gene Therapy for Blindness

(2013) José-Alain Sahel et al.   Annual Review of Neuroscience

Age-Related Cochlear Synaptopathy: An Early-Onset Contributor to Auditory Functional Decline

(2013) Y. Sergeyenko et al.   JOURNAL OF NEUROSCIENCE

Principles for Valid Histopathologic Scoring in Research

(2013) K. N. Gibson-Corley et al.   VETERINARY PATHOLOGY

Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy

(2012) Omar Akil et al.   NEURON

Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice

(2011) Kelly L. Kane et al.   HEARING RESEARCH

Viral Single-Strand DNA Induces p53-Dependent Apoptosis in Human Embryonic Stem Cells

(2011) Matthew L. Hirsch et al.   PLoS One

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis

(2009) S. Someya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA