Article
Multidisciplinary Sciences
Hui Hong, Douglas Zeppenfeld, Laurence O. Trussell
Summary: Efferent neurons, specifically the lateral olivocochlear (LOC) neurons, play vital roles in maintaining auditory function. Through in vitro experiments, it was discovered that LOC neurons in juvenile and young adult mice exhibited extremely slow waves of activity driven by an intrinsic oscillator dependent on L-type Ca2+ channels. Additionally, optogenetic approaches helped identify both ascending and descending sources of synaptic excitation, as well as the synaptic receptors involved. These findings provide important insights into the mechanisms of diverse transmitter release by LOC fibers in the cochlea.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Computer Science, Artificial Intelligence
Faramarz Faghihi, Siqi Cai, Ahmed A. Moustafa
Summary: This study introduces a spiking neural network model for auditory spatial attention detection, showing improved accuracy with the use of limited training data. The model leverages the role of sparse coding in cognitive tasks and brain-inspired machine learning.
Article
Audiology & Speech-Language Pathology
David Perez-Gonzalez, Gloria G. Parras, Camilo J. Morado-Diaz, Cristian Aedo-Sanchez, Guillermo V. Carbajal, Manuel S. Malmierca
Summary: This study investigated neuronal activities in the auditory cortex of animals under the oddball paradigm and found that both fast spiking and regular spiking neurons showed similar levels of deviance detection overall. However, in A1 area, fast spiking neurons exhibited significantly higher levels of deviance detection compared to regular spiking neurons.
Article
Multidisciplinary Sciences
Yousang Yoon, Hyogeun Shin, Donghak Byun, Jiwan Woo, Yakdol Cho, Nakwon Choi, Il-Joo Cho
Summary: The authors present a wireless neural probe system with drug delivery capability for real-time monitoring of drug effects on both behavioral and neural activities in mice. The system allows for simultaneous monitoring of neural and behavioral changes and demonstrates dose-dependent and repeatable responses to drugs. The system is also used to analyze the changes in neural activity during modulated social interaction in pairs of mice. This technology provides new opportunities for studying the effects of drugs on behavior and neural activity.
NATURE COMMUNICATIONS
(2022)
Article
Audiology & Speech-Language Pathology
Yuanyuan Wang, Molly Cooke, Jessa Reed, Laura Dilley, Derek M. Houston
Summary: This study explored the differences in the home auditory environment experienced by children with cochlear implants (CIs) and children with normal hearing (NH). The results showed that measures of conversational turns and child vocalizations did not change with age for children with CIs, whereas they increased with age for children with NH. Additionally, noise levels were significantly higher for children with NH. These findings have implications for early intervention programs to promote spoken language development for children with CIs.
Article
Audiology & Speech-Language Pathology
Raymond L. Goldsworthy, Susan R. S. Bissmeyer
Summary: This study aimed to characterize cochlear implant users' pitch perception for different types of tones and test their reliance on stimulation place and rate cues for pitch discrimination. The results showed that CI users integrate place and rate cues across the ecologically essential pitch range. They had better pitch discrimination for low-pass filtered harmonic complexes and amplitude-modulated tones when provided a covarying place cue.
Article
Otorhinolaryngology
Erva Degirmenci Uzun, Merve Ozbal Batuk, Hilal Dincer D'Alessandrob, Gonca Sennaroglu
Summary: The study evaluates auditory perception and speech intelligibility outcomes in children with cochlear nerve hypoplasia who received cochlear implants. The results demonstrate that cochlear implants are effective in improving auditory perception and speech production in these children, despite the negative impact of cochlear nerve hypoplasia on their auditory performance.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yasumi Ohta, Takaaki E. Murakami, Mamiko Kawahara, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Kiyotaka Sasagawa, Jun Ohta, Metin Akay, Yasemin M. Akay
Summary: This study confirms the importance of dopamine in reward behavior, as well as the interaction between dopaminergic and GABAergic neurons. The researchers used optogenetics to stimulate neurons in mice and measured dopamine release. The results show that different stimulation frequencies have different effects on dopamine release, and GABAergic neurons have an inhibitory effect on dopamine activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Rosanne Abrahamse, Andy Beynon, Vitoria Piai
Summary: The study investigated the auditory discrimination in early implanted, young adult cochlear implant users using event-related potentials, finding that P300 amplitude correlated with speech perception scores and duration of deafness. The P300 provided a robust measure for auditory processing on an individual level, suggesting good auditory outcomes in this population.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Quirin Gehmacher, Patrick Reisinger, Thomas Hartmann, Thomas Keintzel, Sebastian Rosch, Konrad Schwarz, Nathan Weisz
Summary: This study found that the auditory nerve in cochlear implant users is sensitive to selective attention, and the relevant neural activity can be decoded from single-trial data. These findings have important implications for the future development of cochlear implant technology and closed-loop systems.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Hafner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boue-Grabot, Michael A. Kienzler, Guillaume Sandoz
Summary: By manipulating neuronal activity using optogenetics and photopharmacology, researchers have developed a light-activatable molecule called LAKI that can block pain-related potassium channels. This molecule has the potential to be a valuable tool for studying these channels, and it can also be used to remotely control pain in animal models without the need for genetic manipulations or viral infection. This non-invasive and reversible approach has applications in pain research and drug screening.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Mirko Zanon, Damiano Zanini, Albrecht Haase
Summary: This article presents optogenetic tools combined with two-photon calcium imaging to selectively stimulate and read out activity patterns in the Drosophila olfactory system, providing insights into the functional connectivity and information flow in the olfactory network.
SCIENTIFIC REPORTS
(2022)
Review
Audiology & Speech-Language Pathology
Georgia Cambridge, Tracey Taylor, Wendy Arnott, Wayne J. Wilson
Summary: This systematic review examined the efficacy of auditory training on auditory outcomes in post lingually deafened adults with cochlear implants. The evidence suggests that certain auditory training can improve specific auditory outcomes, such as phonemic training improving phoneme identification and nonsense word training enhancing sentence recognition in noise. High quality studies are needed to determine the most effective auditory training for improving outcomes in this population.
INTERNATIONAL JOURNAL OF AUDIOLOGY
(2022)
Review
Biology
Paris Binos, Elina Nirgianaki, George Psillas
Summary: The study highlights the effectiveness of auditory-verbal therapy (AVT) for children with cochlear implants (CIs), showing that participants can achieve similar linguistic skills to their hearing peers, but with lesser benefits in reading skills. Despite improvements in speech and language, the ultimate goal of AV therapy for young children with CIs remains unmet, making it the best clinical practice so far but lacking well-controlled studies to support its efficacy.
Article
Neurosciences
Tohar S. Yarden, Adi Mizrahi, Israel Nelken
Summary: This study investigated the role of inhibition in auditory cortex in stimulus-specific adaptation (SSA). Using two-photon targeted cell-attached recordings and optogenetic manipulations, the researchers found that parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP) expressing interneurons showed early-onset SSA. Surprisingly, inhibiting PV neurons enhanced responses to deviant stimuli more than to standard stimuli, while inhibiting VIP neurons decreased responses to standard stimuli but not to deviant stimuli.
JOURNAL OF NEUROSCIENCE
(2022)