Endothelial signaling and the molecular basis of arteriovenous malformation

Endothelial RAF1/ERK activation regulates arterial morphogenesis

(2013) Y. Deng et al.   BLOOD

Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models

(2013) B. Cristofaro et al.   DEVELOPMENT

Bevacizumab in the treatment of hereditary hemorrhagic telangiectasia

(2013) Theoni Kanellopoulou et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II

(2012) Jai-Hyun Kim et al.   ANGIOGENESIS

BMP9 regulates endoglin-dependent chemokine responses in endothelial cells

(2012) K. Young et al.   BLOOD

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling

(2012) N. Ricard et al.   BLOOD

Minimal Homozygous Endothelial Deletion of Eng with VEGF Stimulation Is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse

(2012) Eun-Jung Choi et al.   CEREBROVASCULAR DISEASES

Endothelial Nuclear Factor-κB–Dependent Regulation of Arteriogenesis and Branching

(2012) Daniela Tirziu et al.   CIRCULATION

Epithelial-to-Mesenchymal and Endothelial-to-Mesenchymal Transition

(2012) Jason C. Kovacic et al.   CIRCULATION

Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades

(2012) Iván M. Moya et al.   DEVELOPMENTAL CELL

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

BMP-9 Induced Endothelial Cell Tubule Formation and Inhibition of Migration Involves Smad1 Driven Endothelin-1 Production

(2012) John E. S. Park et al.   PLoS One

Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis

(2012) Satoshi Somekawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch4 Normalization Reduces Blood Vessel Size in Arteriovenous Malformations

(2012) P. A. Murphy et al.   Science Translational Medicine

Age-Dependent Lethality in Novel Transgenic Mouse Models of Central Nervous System Arteriovenous Malformations

(2012) Ian Milton et al.   STROKE

Bevacizumab Attenuates VEGF-Induced Angiogenesis and Vascular Malformations in the Adult Mouse Brain

(2012) Espen J. Walker et al.   STROKE

FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression

(2012) Pei-Yu Chen et al.   Cell Reports

Interaction between alk1 and blood flow in the development of arteriovenous malformations

(2011) P. Corti et al.   DEVELOPMENT

Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch

(2011) Fangfei Li et al.   DEVELOPMENTAL CELL

Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase

(2011) Alex C.Y. Chang et al.   DEVELOPMENTAL CELL

Matrix Gla protein deficiency causes arteriovenous malformations in mice

(2011) Yucheng Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Arteriovenous Malformations: Epidemiology and Clinical Presentation

(2011) Aki Laakso et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Overlapping spectra ofSMAD4mutations in juvenile polyposis (JP) and JP-HHT syndrome

(2010) Carol Gallione et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Arteriovenous malformation in the adult mouse brain resembling the human disease

(2010) Espen J. Walker et al.   ANNALS OF NEUROLOGY

Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment

(2010) Claire L. Shovlin   BLOOD REVIEWS

Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin

(2010) Marwa Mahmoud et al.   CIRCULATION RESEARCH

Notch and Transforming Growth Factor-β (TGFβ) Signaling Pathways Cooperatively Regulate Vascular Smooth Muscle Cell Differentiation

(2010) Yuefeng Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial cells in the context of brain arteriovenous malformations

(2010) Vanessa Sammons et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia

(2010) Franck Lebrin et al.   NATURE MEDICINE

Signaling by members of the TGF-β family in vascular morphogenesis and disease

(2010) Evangelia Pardali et al.   TRENDS IN CELL BIOLOGY

VEGF Induces More Severe Cerebrovascular Dysplasia in Eng+/− than in Alk1+/− Mice

(2010) Qi Hao et al.   Translational Stroke Research

Regulation of TGF-  signaling by Smad7

(2009) X. Yan et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Soluble endoglin modulates aberrant cerebral vascular remodeling

(2009) Yongmei Chen et al.   ANNALS OF NEUROLOGY

Spontaneous Adult-Onset Pulmonary Arterial Hypertension Attributable to Increased Endothelial Oxidative Stress in a Murine Model of Hereditary Hemorrhagic Telangiectasia

(2009) Mourad Toporsian et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells

(2009) E. S. Shao et al.   BLOOD

Notch-1 signalling is activated in brain arteriovenous malformations in humans

(2009) Q. ZhuGe et al.   BRAIN

Emerging role of bone morphogenetic proteins in angiogenesis

(2009) Laurent David et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cellular and Molecular Mechanisms of Vascular Lumen Formation

(2009) M. Luisa Iruela-Arispe et al.   DEVELOPMENTAL CELL

Differential Regulation of Transforming Growth Factor β Signaling Pathways by Notch in Human Endothelial Cells

(2009) YangXin Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease

(2009) Patrick A Murphy et al.   LABORATORY INVESTIGATION

EVIDENCE OF INFLAMMATORY CELL INVOLVEMENT IN BRAIN ARTERIOVENOUS MALFORMATIONS

(2009) Yongmei Chen et al.   NEUROSURGERY

ABERRANT ANGIOGENIC CHARACTERISTICS OF HUMAN BRAIN ARTERIOVENOUS MALFORMATION ENDOTHELIAL CELLS

(2009) Mark N. Jabbour et al.   NEUROSURGERY

Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation

(2008) Qi Hao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endoglin in angiogenesis and vascular diseases

(2008) Peter ten Dijke et al.   ANGIOGENESIS

Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos

(2008) A. Trindade et al.   BLOOD

Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli

(2008) Rui Benedito et al.   BMC DEVELOPMENTAL BIOLOGY

Signaling cross-talk between TGF-β/BMP and other pathways

(2008) Xing Guo et al.   CELL RESEARCH

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH

Cell-autonomous requirement for  1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice

(2008) T. R. Carlson et al.   DEVELOPMENT

Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis

(2008) Y. H. Kim et al.   DEVELOPMENT

Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused byRASA1 mutations

(2008) Nicole Revencu et al.   HUMAN MUTATION

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice

(2008) P. A. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2

(2007) S. O. Park et al.   BLOOD

Inflammatory molecule expression in cerebral arteriovenous malformations

(2007) Kingsley P. Storer et al.   JOURNAL OF CLINICAL NEUROSCIENCE