Neurodynamic Treatment Promotes Mechanical Pain Modulation in Sensory Neurons and Nerve Regeneration in Rats

Cryo-EM structure of the human TACAN in a closed state

(2022) Xiaozhe Chen et al.   Cell Reports

Toll-Like Receptor 9-Mediated Neuronal Innate Immune Reaction Is Associated with Initiating a Pro-Regenerative State in Neurons of the Dorsal Root Ganglia Non-Associated with Sciatic Nerve Lesion

(2021) Petr Dubový et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats

(2021) F.H.G. Ahlström et al.   MOLECULAR NEUROBIOLOGY

Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway

(2021) Seung Min Shin et al.   PAIN

The neurodynamic treatment induces biological changes in sensory and motor neurons in vitro

(2021) Giacomo Carta et al.   Scientific Reports

Sexual Dimorphism of Early Transcriptional Reprogramming in Dorsal Root Ganglia After Peripheral Nerve Injury

(2021) Andrei V. Chernov et al.   Frontiers in Molecular Neuroscience

Neurodynamics: is tension contentious?

(2021) Richard Ellis et al.   Journal of Manual & Manipulative Therapy

TACAN Is an Ion Channel Involved in Sensing Mechanical Pain

(2020) Lou Beaulieu-Laroche et al.   CELL

Touching Base with Mechanical Pain

(2020) Oscar M. Arenas et al.   CELL

The analgesic action of larixyl acetate, a potent TRPC6 inhibitor, in rat neuropathic pain model induced by spared nerve injury

(2020) Jing Wang et al.   Journal of Neuroinflammation

Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2/MyD88/NF-κB signaling pathway in spinal microglia

(2020) Hao Yang et al.   Journal of Neuroinflammation

Evaluation of Treatment Patterns and Direct Costs Associated with the Management of Neuropathic Pain

(2020) Manuel E Machado-Duque et al.   Pain Research & Management

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat

(2020) Diogo Casal et al.   Jove-Journal of Visualized Experiments

Neuropathic pain in the community: prevalence, impact, and risk factors

(2020) Blair H. Smith et al.   PAIN

John J. Bonica Award Lecture: Peripheral neuronal hyperexcitability: the “low-hanging” target for safe therapeutic strategies in neuropathic pain

(2020) Srinivasa N. Raja et al.   PAIN

Pharmacological modulation of voltage-gated sodium (NaV) channels alters nociception arising from the female reproductive tract

(2020) Joel Castro et al.   PAIN

The Effectiveness of Dorsal Root Ganglion Neurostimulation for the Treatment of Chronic Pelvic Pain and Chronic Neuropathic Pain of the Lower Extremity: A Comprehensive Review of the Published Data

(2020) Ameet Nagpal et al.   PAIN MEDICINE

Revisiting PNS Plasticity: How Uninjured Sensory Afferents Promote Neuropathic Pain

(2020) Emily L. Tran et al.   Frontiers in Cellular Neuroscience

The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury

(2020) Sara Hestehave et al.   Scientific Reports

Peripheral Neuropathic Pain: From Experimental Models to Potential Therapeutic Targets in Dorsal Root Ganglion Neurons

(2020) Ti-Yen Yeh et al.   Cells

Involvement of TACAN, a Mechanotransducing Ion Channel, in Inflammatory But Not Neuropathic Hyperalgesia in the Rat

(2020) Ivan J.M. Bonet et al.   JOURNAL OF PAIN

Effects of active versus passive upper extremity neural mobilization combined with mechanical traction and mobilization in females with cervical radiculopathy: A randomized controlled trial

(2019) Afsah Ayub et al.   JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION

Neural gliding and neural tensioning differently impact flexibility, heat and pressure pain thresholds in asymptomatic subjects: A randomized, parallel and double-blind study

(2019) Carolina Martins et al.   PHYSICAL THERAPY IN SPORT

Sex differences in gene regulation in the dorsal root ganglion after nerve injury

(2019) Kimberly E. Stephens et al.   BMC GENOMICS

Suppression of neuropathic pain by selective silencing of DRG ectopia using non-blocking concentrations of lidocaine

(2019) Shai-lee Yatziv et al.   PAIN

Neuromodulation of the Dorsal Root Ganglion for Chronic Postsurgical Pain

(2019) Ajay B Antony et al.   PAIN MEDICINE

Stress sensitivity and cutaneous sensory thresholds before and after neuropathic injury in various inbred and outbred rat strains

(2019) Sara Hestehave et al.   BEHAVIOURAL BRAIN RESEARCH

Windup of Nociceptive Flexion Reflex Depends on Synaptic and Intrinsic Properties of Dorsal Horn Neurons in Adult Rats

(2019) Franck Aby et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neurodynamic Techniques Versus “Sham” Therapy in the Treatment of Carpal Tunnel Syndrome: A Randomized Placebo-Controlled Trial

(2018) Tomasz Wolny et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Late administration of high-frequency electrical stimulation increases nerve regeneration without aggravating neuropathic pain in a nerve crush injury

(2018) Hong-Lin Su et al.   BMC NEUROSCIENCE

Non-pharmacological treatment affects neuropeptide expression in neuropathic pain model

(2018) Fabio Martinez Santos et al.   BRAIN RESEARCH

Effects of a Novel Neurodynamic Tension Technique on Muscle Extensibility and Stretch Tolerance: A Counterbalanced Crossover Study

(2018) Max Pietrzak et al.   JOURNAL OF SPORT REHABILITATION

To treat pain, study people in all their complexity

(2018) Beth Darnall   NATURE

Dilute lidocaine suppresses ectopic neuropathic discharge in dorsal root ganglia without blocking axonal propagation

(2018) Pini Koplovitch et al.   PAIN

Should thoracic paravertebral blocks be used to prevent chronic postsurgical pain after breast cancer surgery? A systematic analysis of evidence in light of IMMPACT recommendations

(2018) Nasir Hussain et al.   PAIN

Activation of Astrocytes and Microglial Cells and CCL2/CCR2 Upregulation in the Dorsolateral and Ventrolateral Nuclei of Periaqueductal Gray and Rostral Ventromedial Medulla Following Different Types of Sciatic Nerve Injury

(2018) Petr Dubový et al.   Frontiers in Cellular Neuroscience

Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling

(2018) Enrique J. Cobos et al.   Cell Reports

A dual noradrenergic mechanism for the relief of neuropathic allodynia by the antidepressant drugs duloxetine and amitriptyline

(2018) Mélanie Kremer et al.   JOURNAL OF NEUROSCIENCE

Is manual therapy based on neurodynamic techniques effective in the treatment of carpal tunnel syndrome? A randomized controlled trial

(2018) Tomasz Wolny et al.   CLINICAL REHABILITATION

Manual therapy prevents onset of nociceptor activity, sensorimotor dysfunction, and neural fibrosis induced by a volitional repetitive task

(2018) Geoffrey M. Bove et al.   PAIN

Efficacy of Manual Therapy Including Neurodynamic Techniques for the Treatment of Carpal Tunnel Syndrome: A Randomized Controlled Trial

(2017) Tomasz Wolny et al.   JOURNAL OF MANIPULATIVE AND PHYSIOLOGICAL THERAPEUTICS

DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain

(2017) Yan Li et al.   JOURNAL OF NEUROSCIENCE

Global miRNA expression analysis identifies novel key regulators of plasma cell differentiation and malignant plasma cell

(2017) Alboukadel Kassambara et al.   NUCLEIC ACIDS RESEARCH

Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months

(2017) Timothy R. Deer et al.   PAIN

Neural Mobilization Attenuates Mechanical Allodynia and Decreases Proinflammatory Cytokine Concentrations in Rats With Painful Diabetic Neuropathy

(2017) Guan-Cheng Zhu et al.   PHYSICAL THERAPY

Touch, Tension, and Transduction – The Function and Regulation of Piezo Ion Channels

(2017) Jason Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats

(2017) Aline Carolina Giardini et al.   Pain Research & Management

Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors

(2017) Vincenzo Prato et al.   Cell Reports

Effect of simvastatin on sensorial, motor, and morphological parameters in sciatic nerve crush induced-neuropathic pain in rats

(2017) Claudia Rita Corso et al.   INFLAMMOPHARMACOLOGY

Slump Test

(2016) Michael Shacklock et al.   SPINE

Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model

(2016) Agnieszka M. Jurga et al.   NEURAL PLASTICITY

Results of an Active Neurodynamic Mobilization Program in Patients With Fibromyalgia Syndrome: A Randomized Controlled Trial

(2015) Janet Rodríguez Torres et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Comparison of Hypoalgesic Effects of Neural Stretching vs Neural Gliding: A Randomized Controlled Trial

(2015) Hector Beltran-Alacreu et al.   JOURNAL OF MANIPULATIVE AND PHYSIOLOGICAL THERAPEUTICS

The effects of different tensile parameters for the neurodynamic mobilization technique on tricipital muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury

(2015) Yan Wang et al.   Journal of NeuroEngineering and Rehabilitation

The neural mobilization technique modulates the expression of endogenous opioids in the periaqueductal gray and improves muscle strength and mobility in rats with neuropathic pain

(2014) Fabio Santos et al.   Behavioral and Brain Functions

Sensory recovery after primary repair of palmar digital nerves using a Revolnerv® collagen conduit: A prospective series of 27 cases

(2014) A. Arnaout et al.   Chirurgie de la Main

Neurite-J: An Image-J plug-in for axonal growth analysis in organotypic cultures

(2014) A. Torres-Espín et al.   JOURNAL OF NEUROSCIENCE METHODS

Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms

(2014) Troels S Jensen et al.   LANCET NEUROLOGY

Electrical Stimulation of Dorsal Root Entry Zone Attenuates Wide-Dynamic-Range Neuronal Activity in Rats

(2014) Fei Yang et al.   NEUROMODULATION

Peripheral nervous system origin of phantom limb pain

(2014) Apostol Vaso et al.   PAIN

Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve

(2013) Petr Dubový et al.   Journal of Neuroinflammation

Neuropathic pain in the general population: A systematic review of epidemiological studies

(2013) O. van Hecke et al.   PAIN

Biophysical stimulation induces demyelination via an integrin-dependent mechanism

(2012) Michael Y. Lin et al.   ANNALS OF NEUROLOGY

Radial Nerve Mobilization Decreases Pain Sensitivity and Improves Motor Performance in Patients With Thumb Carpometacarpal Osteoarthritis: A Randomized Controlled Trial

(2012) Jorge H. Villafañe et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Normal inter-limb differences during the straight leg raise neurodynamic test: a cross sectional study

(2012) Benjamin S Boyd et al.   BMC MUSCULOSKELETAL DISORDERS

Pain Medicine Versus Pain Management

(2012) John D. Loeser et al.   CLINICAL JOURNAL OF PAIN

Neural Mobilization Reverses Behavioral and Cellular Changes That Characterize Neuropathic Pain in Rats

(2012) Fabio M Santos et al.   Molecular Pain

The role of TLR2 in nerve injury-induced neuropathic pain is essentially mediated through macrophages in peripheral inflammatory response

(2010) Xiang Qun Shi et al.   GLIA

Bilateral changes of TNF-α and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve

(2010) Radim Jančálek et al.   Journal of Neuroinflammation

The Vermicelli and Capellini Handling Tests: Simple quantitative measures of dexterous forepaw function in rats and mice

(2010) Kelly A. Tennant et al.   Jove-Journal of Visualized Experiments

Paravertebral block: cervical, thoracic, lumbar, and sacral

(2009) André P Boezaart et al.   Current Opinion in Anesthesiology

Functional and morphological assessment of a standardized crush injury of the rat median nerve

(2009) G. Ronchi et al.   JOURNAL OF NEUROSCIENCE METHODS

Mechanosensitivity of the Lower Extremity Nervous System During Straight-Leg Raise Neurodynamic Testing in Healthy Individuals

(2009) Benjamin S. Boyd et al.   JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications of Tensile Loading for the Tissue Engineering of Nerves

(2008) Franklin Rivera Bueno et al.   TISSUE ENGINEERING PART B-REVIEWS