Designing for sustainability with biocatalytic and chemoenzymatic cascade processes

Alcohol Dehydrogenases and N‐Heterocyclic Carbene Gold(I) Catalysts: Design of a Chemoenzymatic Cascade towards Optically Active β,β‐Disubstituted Allylic Alcohols

(2021) Sergio González‐Granda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Incorporation of Metals and Enzymes with Porous Imine Molecule Cages for Highly Efficient Semiheterogeneous Chemoenzymatic Catalysis

(2021) Shiqi Gao et al.   ACS Catalysis

One-Pot Asymmetric Synthesis of an Aminodiol Intermediate of Florfenicol Using Engineered Transketolase and Transaminase

(2021) Qi Liu et al.   ACS Catalysis

Phage-Assisted Continuous Evolution and Selection of Enzymes for Chemical Synthesis

(2021) Krysten A. Jones et al.   ACS Central Science

Enzyme engineering for biosynthetic cascades

(2021) John A. McIntosh et al.   Current Opinion in Green and Sustainable Chemistry

Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

(2021) John A. McIntosh et al.   ACS Central Science

Deep Dive into Machine Learning Models for Protein Engineering

(2020) Yuting Xu et al.   Journal of Chemical Information and Modeling

One‐Pot Synthesis of Chiral N ‐Arylamines by Combining Biocatalytic Aminations with Buchwald–Hartwig N ‐Arylation

(2020) Sebastian C. Cosgrove et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Double Enzyme-Catalyzed One-Pot Synthesis of Enantiocomplementary Vicinal Fluoro Alcohols

(2020) Jiajie Fan et al.   ORGANIC LETTERS

Recent Advances in Re-engineering Modular PKS and NRPS Assembly Lines

(2020) Charlotte Beck et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Integrated Electro‐Biocatalysis for Amine Alkylation with Alcohols

(2020) Itziar Peñafiel et al.   ChemCatChem

Arylative Allenol Cyclization via Sequential One‐pot Enzyme & Palladium Catalysis

(2020) Janne M. Naapuri et al.   ChemCatChem

Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

(2019) Jeremy I. Ramsden et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions

(2019) Lieuwe Biewenga et al.   ACS Catalysis

Approaching Bulk Chemical Nitriles from Alkenes: A Hydrogen Cyanide-Free Approach through Combination of Hydroformylation and Biocatalysis

(2019) Carmen Plass et al.   ACS Catalysis

Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd(0)‐CalB CLEA as a Biohybrid Catalyst

(2019) Jan-E. Bäckvall et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bridging the gap between transition metal- and bio-catalysis via aqueous micellar catalysis

(2019) Margery Cortes-Clerget et al.   Nature Communications

Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

(2019) Markus Schober et al.   Nature Catalysis

Combined Photoredox/Enzymatic C−H Benzylic Hydroxylations

(2019) Rick C. Betori et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N-Heterocycles

(2019) Thomas W. Thorpe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources

(2019) Shuke Wu et al.   Nature Communications

Mass Activated Droplet Sorting (MADS) Enables High-Throughput Screening of Enzymatic Reactions at Nanoliter Scale

(2019) Daniel A. Holland-Moritz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Biocatalytic Transformation of Adipic Acid to 6-Aminocaproic Acid and 1,6-Hexamethylenediamine Using Carboxylic Acid Reductases and Transaminases

(2019) Tatiana P. Fedorchuk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

(2019) Mark A. Huffman et al.   SCIENCE

Baeyer–Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation

(2018) Yong Koy Bong et al.   JOURNAL OF ORGANIC CHEMISTRY

Heterogeneous Metal-Organic-Framework-Based Biohybrid Catalysts for Cascade Reactions in Organic Solvent

(2018) Yangxin Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Combining Photo-Organo Redox- and Enzyme Catalysis Facilitates Asymmetric C-H Bond Functionalization

(2018) Wuyuan Zhang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis of 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) via Enzymatic Desymmetrization

(2017) Mark McLaughlin et al.   ORGANIC LETTERS

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

(2016) Scott P. France et al.   ACS Catalysis

Using the Right Green Yardstick: Why Process Mass Intensity Is Used in the Pharmaceutical Industry To Drive More Sustainable Processes

(2011) Concepcion Jimenez-Gonzalez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE