Combined Photoredox/Enzymatic C−H Benzylic Hydroxylations

Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases

(2019) Braddock A. Sandoval et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photo-Biocatalysis: Biotransformations in the Presence of Light

(2019) Luca Schmermund et al.   ACS Catalysis

Photoexcitation of flavoenzymes enables a stereoselective radical cyclization

(2019) Kyle F. Biegasiewicz et al.   SCIENCE

Cascading g-C3N4 and Peroxygenases for Selective Oxyfunctionalization Reactions

(2019) Morten M. C. H. van Schie et al.   ACS Catalysis

Biocatalytic Oxidation Reactions: A Chemist's Perspective

(2018) JiaJia Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrochemical strategies for C–H functionalization and C–N bond formation

(2018) Markus D. Kärkäs   CHEMICAL SOCIETY REVIEWS

Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases

(2018) Kyle F. Biegasiewicz et al.   Nature Chemistry

Enantioselective synthesis of amines by combining photoredox and enzymatic catalysis in a cyclic reaction network

(2018) Xingwei Guo et al.   Chemical Science

Aliphatic C—H Oxidations for Late-Stage Functionalization

(2018) M. Christina White et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis

(2018) Zachary C. Litman et al.   NATURE

Biocatalysis in Drug Development—Highlights of the Recent Patent Literature

(2018) David L. Hughes   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Combining Photo-Organo Redox- and Enzyme Catalysis Facilitates Asymmetric C-H Bond Functionalization

(2018) Wuyuan Zhang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization

(2018) Ruijie K. Zhang et al.   NATURE

Extending the application of biocatalysis to meet the challenges of drug development

(2018) Paul N. Devine et al.   Nature Reviews Chemistry

Selective C H bond functionalization with engineered heme proteins: new tools to generate complexity

(2018) Ruijie K Zhang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Scalable, Electrochemical Oxidation of Unactivated C–H Bonds

(2017) Yu Kawamata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Remote, Late-Stage Oxidation of Aliphatic C–H Bonds in Amide-Containing Molecules

(2017) Takeshi Nanjo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent ‘Ene’-Reductases

(2017) Braddock A. Sandoval et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme

(2017) Christopher K. Prier et al.   Nature Chemistry

Recent progress in mild Csp3–H bond dehydrogenative or (mono-) oxidative functionalization

(2017) Andrea Gini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Exploring the Reducing Ability of Organic Dye (Acr+-Mes) for Fluorination and Oxidation of Benzylic C(sp3)–H Bonds under Visible Light Irradiation

(2017) Ming Xiang et al.   ORGANIC LETTERS

Redesign of a Pyrylium Photoredox Catalyst and Its Application to the Generation of Carbonyl Ylides

(2017) Edwin Alfonzo et al.   ORGANIC LETTERS

A unified photoredox-catalysis strategy for C(sp3)–H hydroxylation and amidation using hypervalent iodine

(2017) Guo-Xing Li et al.   Chemical Science

Organic Photoredox Catalysis

(2016) Nathan A. Romero et al.   CHEMICAL REVIEWS

Mild metal-catalyzed C–H activation: examples and concepts

(2016) T. Gensch et al.   CHEMICAL SOCIETY REVIEWS

Selective Oxidative Esterification from Two Different Alcohols via Photoredox Catalysis

(2016) Hong Yi et al.   ChemSusChem

Visible-light induced oxidative Csp3–H activation of methyl aromatics to methyl esters

(2016) Lingling Zhang et al.   GREEN CHEMISTRY

Benzylic C(sp3)–H Functionalization for C–N and C–O Bond Formation via Visible Light Photoredox Catalysis

(2016) Ganesh Pandey et al.   JOURNAL OF ORGANIC CHEMISTRY

Photoredox Catalysis in Organic Chemistry

(2016) Megan H. Shaw et al.   JOURNAL OF ORGANIC CHEMISTRY

Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light

(2016) Megan A. Emmanuel et al.   NATURE

Visible Light Photocatalysis: Applications and New Disconnections in the Synthesis of Pharmaceutical Agents

(2016) James J. Douglas et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Enantioselective cyanation of benzylic C–H bonds via copper-catalyzed radical relay

(2016) Wen Zhang et al.   SCIENCE

Aerobic Oxidation of Benzylic sp3 C−H Bonds through Cooperative Visible-Light Photoredox Catalysis of N -Hydroxyimide and Dicyanopyrazine

(2016) Xinfei Liu et al.   Asian Journal of Organic Chemistry

Amine Functionalization via Oxidative Photoredox Catalysis: Methodology Development and Complex Molecule Synthesis

(2015) Joel W. Beatty et al.   ACCOUNTS OF CHEMICAL RESEARCH

Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution

(2015) Hans Renata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible light mediated efficient oxidative benzylic sp3 C–H to ketone derivatives obtained under mild conditions using O2

(2015) Hong Yi et al.   CHEMICAL COMMUNICATIONS

Remote Oxidation of Aliphatic C–H Bonds in Nitrogen-Containing Molecules

(2015) Jennifer M. Howell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterizing chain processes in visible light photoredox catalysis

(2015) Megan A. Cismesia et al.   Chemical Science

Specific oxyfunctionalisations catalysed by peroxygenases: opportunities, challenges and solutions

(2015) Sebastian Bormann et al.   Catalysis Science & Technology

Combining the ‘two worlds’ of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media

(2014) Harald Gröger et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Organic synthetic transformations using organic dyes as photoredox catalysts

(2014) Shunichi Fukuzumi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

(2013) Christopher K. Prier et al.   CHEMICAL REVIEWS

C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

(2013) Joanna Wencel-Delord et al.   Nature Chemistry

Chiral 1,1-diaryl compounds as important pharmacophores

(2013) Dana Ameen et al.   MedChemComm

An N-bridged high-valent diiron–oxo species on a porphyrin platform that can oxidize methane

(2012) Evgeny V. Kudrik et al.   Nature Chemistry

A highly selective vanadium catalyst for benzylic C–H oxidation

(2012) Ji-Bao Xia et al.   Chemical Science

Tuning P450 Enzymes as Oxidation Catalysts

(2012) Rudi Fasan   ACS Catalysis

Photoredox Catalysis as an Efficient Tool for the Aerobic Oxidation of Amines and Alcohols: Bioinspired Demethylations and Condensations

(2012) Magnus Rueping et al.   ACS Catalysis

Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution

(2011) Sabrina Kille et al.   Nature Chemistry

Enzymatic functionalization of carbon–hydrogen bonds

(2010) Jared C. Lewis et al.   CHEMICAL SOCIETY REVIEWS

Combined Effects on Selectivity in Fe-Catalyzed Methylene Oxidation

(2010) M. S. Chen et al.   SCIENCE

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Sequential and Modular Synthesis of Chiral 1,3-Diols with Two Stereogenic Centers: Access to All Four Stereoisomers by Combination of Organo- and Biocatalysis

(2009) Katrin Baer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

P450 Enzymes: Their Structure, Reactivity, and Selectivity—Modeled by QM/MM Calculations

(2009) Sason Shaik et al.   CHEMICAL REVIEWS

Modular Chemoenzymatic One-Pot Syntheses in Aqueous Media: Combination of a Palladium-Catalyzed Cross-Coupling with an Asymmetric Biotransformation

(2008) Edyta Burda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu-Facilitated C−O Bond Formation UsingN-Hydroxyphthalimide: Efficient and Selective Functionalization of Benzyl and Allylic C−H Bonds

(2008) Ji Min Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion

(2008) Huw M. L. Davies et al.   NATURE

Chemo-enzymatic fluorination of unactivated organic compounds

(2008) Andrea Rentmeister et al.   Nature Chemical Biology