Edaravone Modulates Neuronal GPX4/ACSL4/5-LOX to Promote Recovery After Spinal Cord Injury

Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway

(2022) Ruozhi Dang et al.   Journal of Neuroinflammation

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Programmed cell death in spinal cord injury pathogenesis and therapy

(2021) Zhongju Shi et al.   CELL PROLIFERATION

Progress in Understanding Ferroptosis and Its Targeting for Therapeutic Benefits in Traumatic Brain and Spinal Cord Injuries

(2021) Xinli Hu et al.   Frontiers in Cell and Developmental Biology

Neurotropin exerts neuroprotective effects after spinal cord injury by inhibiting apoptosis and modulating cytokines

(2020) Xue Yao et al.   Journal of Orthopaedic Translation

TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data

(2020) Chengjie Chen et al.   Molecular Plant

Edaravone: A potential treatment for the COVID-19-induced inflammatory syndrome?

(2020) Sandra E. Reznik et al.   PHARMACOLOGICAL RESEARCH

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

(2020) Nandini Verma et al.   Science Advances

Time is spine: a review of translational advances in spinal cord injury

(2019) Jetan H. Badhiwala et al.   JOURNAL OF NEUROSURGERY-SPINE

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Spinal cord repair: advances in biology and technology

(2019) Grégoire Courtine et al.   NATURE MEDICINE

Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro

(2019) Takujiro Homma et al.   EXPERIMENTAL CELL RESEARCH

Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)

(2019) Hongyun Huang et al.   Journal of Orthopaedic Translation

Free radical scavenger edaravone produces robust neuroprotection in a rat model of spinal cord injury

(2018) Hideaki Ishii et al.   BRAIN RESEARCH

Edaravone, a free radical scavenger, protects neuronal cells’ mitochondria from ischemia by inactivating another new critical factor of the 5-lipoxygenase pathway affecting the arachidonic acid metabolism

(2018) Ying Song et al.   BRAIN RESEARCH

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Microenvironment Imbalance of Spinal Cord Injury

(2018) Baoyou Fan et al.   CELL TRANSPLANTATION

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Ferroptosis and necroinflammation, a yet poorly explored link

(2018) Bettina Proneth et al.   CELL DEATH AND DIFFERENTIATION

Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury

(2018) Qishuang Zhou et al.   JOURNAL OF NEUROTRAUMA

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury

(2018) Elizabeth M. Kenny et al.   CRITICAL CARE MEDICINE

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Volitional social interaction prevents drug addiction in rat models

(2018) Marco Venniro et al.   NATURE NEUROSCIENCE

Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury

(2018) Yan Zhang et al.   BRAIN RESEARCH

Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone)

(2017) Tomomi Masuda et al.   Oxidative Medicine and Cellular Longevity

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

(2016) Dearbhaile Dooley et al.   Stem Cell Reports

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

(2015) Yang Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits

(2015) Shu-Sheng Jiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The Therapeutic Role of Interleukin-10 after Spinal Cord Injury

(2013) Colton D. Thompson et al.   JOURNAL OF NEUROTRAUMA

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Effects of Continuous Intravenous Infusion of MCI-186 on Functional Recovery after Spinal Cord Injury in Rats

(2010) Souichi Ohta et al.   JOURNAL OF NEUROTRAUMA

Effects of zileuton and montelukast in mouse experimental spinal cord injury

(2007) T Genovese et al.   BRITISH JOURNAL OF PHARMACOLOGY