Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits

Amyloid-β42 Activates the Expression of BACE1 Through the JNK Pathway

(2018) Michela Guglielmotto et al.   JOURNAL OF ALZHEIMERS DISEASE

Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice

(2015) Byung Hee Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Lessons from immunotherapy for Alzheimer disease

(2014) Yan-Jiang Wang   Nature Reviews Neurology

cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

(2014) Becky C. Carlyle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory Effects of Edaravone inβ-Amyloid-Induced Neurotoxicity in Rats

(2014) Feng He et al.   Biomed Research International

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

γ-Secretase inhibitors and modulators

(2013) Todd E. Golde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cerebral amyloidal angiopathy—A disease with implications for neurology and psychiatry

(2013) Maximilian Gahr et al.   BRAIN RESEARCH

The State of US Health, 1990-2010

(2013) Christopher J. L. Murray   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Edaravone Ameliorates Oxidative Damage Associated with Aβ25-35 Treatment in PC12 Cells

(2013) Gui-lian Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Beta amyloid, tau, neuroimaging, and cognition: sequence modeling of biomarkers for Alzheimer’s Disease

(2012) S. Duke Han et al.   Brain Imaging and Behavior

Nuclear Factor-κB Regulates βAPP and β- and γ-Secretases Differently at Physiological and Supraphysiological Aβ Concentrations

(2012) Linda Chami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

(2012) Linda Chami et al.   Molecular Neurodegeneration

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

p75NTR Regulates A  Deposition by Increasing A  Production But Inhibiting A  Aggregation with Its Extracellular Domain

(2011) Y.-J. Wang et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β Production: Major Link Between Oxidative Stress and BACE1

(2011) Elena Tamagno et al.   NEUROTOXICITY RESEARCH

Molecular basis for amyloid-  polymorphism

(2011) J.-P. Colletier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The future of Alzheimer's disease: The next 10 years

(2011) Harald Hampel et al.   PROGRESS IN NEUROBIOLOGY

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Epigenetics, oxidative stress, and Alzheimer disease

(2009) Nasser H. Zawia et al.   FREE RADICAL BIOLOGY AND MEDICINE

The amyloid cascade hypothesis

(2008) Amos D. Korczyn   Alzheimers & Dementia

The Novel Antioxidant Edaravone: From Bench to Bedside

(2008) Toshiaki Watanabe et al.   Cardiovascular Therapeutics

NFκB-dependent Control ofBACE1Promoter Transactivation by Aβ42

(2008) Virginie Buggia-Prevot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3  Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing

(2008) Y. Wen et al.   JOURNAL OF NEUROSCIENCE

Grape-Derived Polyphenolics Prevent A  Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

(2008) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

(2008) Raj N Kalaria et al.   LANCET NEUROLOGY