Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants

Anomalous collapses of Nares Strait ice arches leads to enhanced export of Arctic sea ice

(2021) G. W. K. Moore et al.   Nature Communications

Dissecting strategies to tune the therapeutic potential of SARS-CoV-2–specific monoclonal antibody CR3022

(2021) Caroline Atyeo et al.   JCI Insight

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

(2021) Emma S. Winkler et al.   CELL

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine induced sera

(2021) Daming Zhou et al.   CELL

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

(2021) Zhuoming Liu et al.   Cell Host & Microbe

Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

(2021) Allison J. Greaney et al.   Cell Host & Microbe

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

(2021) Rita E. Chen et al.   NATURE MEDICINE

Coronavirus entry: how we arrived at SARS-CoV-2

(2021) Gary R Whittaker et al.   Current Opinion in Virology

The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 Pandemic

(2021) Priyanka Shah et al.   Frontiers in Immunology

Spike S2 Subunit: The Dark Horse in the Race for Prophylactic and Therapeutic Interventions against SARS-CoV-2

(2021) Kim Tien Ng et al.   Vaccines

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

(2021) Markus Hoffmann et al.   CELL

Structural basis for broad coronavirus neutralization

(2021) Maximilian M. Sauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

(2021) William N. Voss et al.   SCIENCE

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

(2021) Chunyan Wang et al.   Nature Communications

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

(2021) Irfan Ullah et al.   IMMUNITY

Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants

(2021) Hsin-I Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19

(2021) Meagan P. O’Brien et al.   NEW ENGLAND JOURNAL OF MEDICINE

Broad betacoronavirus neutralization by a stem helix–specific human antibody

(2021) Dora Pinto et al.   SCIENCE

Serum Neutralizing Activity against B.1.1.7, B.1.351, and P.1 SARS-CoV-2 Variants of Concern in Hospitalized COVID-19 Patients

(2021) Claudia Maria Trombetta et al.   Viruses-Basel

Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects

(2021) Madeleine F. Jennewein et al.   Cell Reports

Mechanisms of SARS-CoV-2 entry into cells

(2021) Cody B. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

(2021) Wenwei Li et al.   Cell Reports

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(2020) Victor M Corman et al.   Eurosurveillance

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

(2020) Shuai Xia et al.   CELL RESEARCH

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

(2020) Wanbo Tai et al.   Cellular & Molecular Immunology

The convalescent sera option for containing COVID-19

(2020) Arturo Casadevall et al.   JOURNAL OF CLINICAL INVESTIGATION

Human neutralizing antibodies elicited by SARS-CoV-2 infection

(2020) Bin Ju et al.   NATURE

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

(2020) Dora Pinto et al.   NATURE

The Current and Future State of Vaccines, Antivirals and Gene Therapies Against Emerging Coronaviruses

(2020) Longping V. Tse et al.   Frontiers in Microbiology

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

(2020) Yuan Huang et al.   ACTA PHARMACOLOGICA SINICA

SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells

(2020) Rolando Cannalire et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities

(2020) Siyu Xiu et al.   JOURNAL OF MEDICINAL CHEMISTRY

In silico design of antiviral peptides targeting the spike protein of SARS-CoV-2

(2020) Rongsong Ling et al.   PEPTIDES

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

(2020) Johanna Hansen et al.   SCIENCE

Distinct conformational states of SARS-CoV-2 spike protein

(2020) Yongfei Cai et al.   SCIENCE

Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development

(2020) Subodh Kumar Samrat et al.   VIRUS RESEARCH

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

(2020) Alexandra Schäfer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2

(2020) Ma’mon M. Hatmal et al.   Cells

Development of Small-Molecule MERS-CoV Inhibitors

(2018) Ruiying Liang et al.   Viruses-Basel

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion

(2017) Alexandra C. Walls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IgBLAST: an immunoglobulin variable domain sequence analysis tool

(2013) Jian Ye et al.   NUCLEIC ACIDS RESEARCH