Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

Neurological infection with SARS-CoV-2 — the story so far

(2021) Tom Solomon   Nature Reviews Neurology

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

(2021) Emma S. Winkler et al.   CELL

Structural basis for broad coronavirus neutralization

(2021) Maximilian M. Sauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

(2021) William N. Voss et al.   SCIENCE

Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice

(2021) Tal Noy-Porat et al.   iScience

Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice

(2021) Jesus A. Silvas et al.   JOURNAL OF VIROLOGY

Dysregulation of brain and choroid plexus cell types in severe COVID-19

(2021) Andrew C. Yang et al.   NATURE

Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects

(2021) Madeleine F. Jennewein et al.   Cell Reports

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

An Infectious cDNA Clone of SARS-CoV-2

(2020) Xuping Xie et al.   Cell Host & Microbe

SARS-CoV-2: Combating Coronavirus Emergence

(2020) Rachel L. Graham et al.   IMMUNITY

Multivesicular bodies mimicking SARS-CoV-2 in patients without COVID-19

(2020) Edward Calomeni et al.   KIDNEY INTERNATIONAL

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

(2020) Rui Shi et al.   NATURE

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

(2020) Ahmed O. Hassan et al.   CELL

Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation

(2020) Emilie Seydoux et al.   IMMUNITY

A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection

(2020) Wafaa B. Alsoussi et al.   JOURNAL OF IMMUNOLOGY

Neurological associations of COVID-19

(2020) Mark A Ellul et al.   LANCET NEUROLOGY

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

Potently neutralizing and protective human antibodies against SARS-CoV-2

(2020) Seth J. Zost et al.   NATURE

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

(2020) Seth J. Zost et al.   NATURE MEDICINE

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

(2020) Thomas F. Rogers et al.   SCIENCE

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

(2020) Ching-Lin Hsieh et al.   SCIENCE

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

(2020) Johanna Hansen et al.   SCIENCE

Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization

(2020) PJ Klasse et al.   eLife

Molecular Architecture of the SARS-CoV-2 Virus

(2020) Hangping Yao et al.   CELL

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

(2020) Sarah R. Leist et al.   CELL

Cell and animal models of SARS-CoV-2 pathogenesis and immunity

(2020) Sarah R. Leist et al.   Disease Models & Mechanisms

COVID-19 Vaccines: Should We Fear ADE?

(2020) Scott B Halstead et al.   JOURNAL OF INFECTIOUS DISEASES

Animal and translational models of SARS-CoV-2 infection and COVID-19

(2020) M. D. Johansen et al.   Mucosal Immunology

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

(2020) Kenneth H. Dinnon et al.   NATURE

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

(2020) Zunlong Ke et al.   NATURE

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges

(2020) Beata Turoňová et al.   SCIENCE

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

(2020) Alina Baum et al.   SCIENCE

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

(2020) M. Alejandra Tortorici et al.   SCIENCE

Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals

(2020) Guillaume Beaudoin-Bussières et al.   mBio

A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

(2020) Xuping Xie et al.   Nature Communications

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

(2020) Joseph W. Golden et al.   JCI Insight

Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles

(2020) Maolin Lu et al.   Cell Host & Microbe

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

(2020) Alexandra Schäfer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

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SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

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SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

(2020) Steffen Klein et al.   Nature Communications

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

(2020) Lizhou Zhang et al.   Nature Communications

A Potent SARS-CoV-2 Neutralizing Human Monoclonal Antibody That Reduces Viral Burden and Disease Severity in Syrian Hamsters

(2020) Anna C. Fagre et al.   Frontiers in Immunology

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

(2019) Maolin Lu et al.   NATURE

Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life

(2019) Kevin O. Saunders   Frontiers in Immunology

Immunological Lessons from Respiratory Syncytial Virus Vaccine Development

(2019) Tracy J. Ruckwardt et al.   IMMUNITY

Differential requirements for FcγR engagement by protective antibodies against Ebola virus

(2019) Stylianos Bournazos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice

(2019) John D. Ventura et al.   PLoS Pathogens

Automated tilt series alignment and tomographic reconstruction in IMOD

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Affinity of human IgG subclasses to mouse Fc gamma receptors

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Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale

(2016) Manuel F Juette et al.   NATURE METHODS

Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism

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Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

(2014) Stylianos Bournazos et al.   CELL

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

(2014) J. B. Munro et al.   SCIENCE

The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection

(2013) Zhenlong Liu et al.   Cell Host & Microbe

Differential Sensitivity of Bat Cells to Infection by Enveloped RNA Viruses: Coronaviruses, Paramyxoviruses, Filoviruses, and Influenza Viruses

(2013) Markus Hoffmann et al.   PLoS One

Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine

(2012) Mark S. Ladinsky et al.   MOLECULAR BIOLOGY OF THE CELL

Mouse model recapitulating human Fc  receptor structural and functional diversity

(2012) P. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

Topological Layers in the HIV-1 gp120 Inner Domain Regulate gp41 Interaction and CD4-Triggered Conformational Transitions

(2010) Andrés Finzi et al.   MOLECULAR CELL

Correction for non-perpendicularity of beam and tilt axis in tomographic reconstructions with the IMOD package

(2008) D. N. MASTRONARDE   JOURNAL OF MICROSCOPY

FcRn-mediated antibody transport across epithelial cells revealed by electron tomography

(2008) Wanzhong He et al.   NATURE