Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

(2020) Aiping Wu et al.   Cell Host & Microbe

Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2

(2020) Zhixin Liu et al.   JOURNAL OF MEDICAL VIROLOGY

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Challenges of coronavirus disease 2019

(2020) The Lancet Infectious Diseases   LANCET INFECTIOUS DISEASES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2

(2020) Yanxiao Han et al.   ACS Nano

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

Structural Proteins in Severe Acute Respiratory Syndrome Coronavirus-2

(2020) Sairaj Satarker et al.   ARCHIVES OF MEDICAL RESEARCH

Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection

(2020) Junwen Luan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

(2020) Shuai Xia et al.   CELL RESEARCH

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

(2020) Wanbo Tai et al.   Cellular & Molecular Immunology

Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?

(2020) Daniel Batlle et al.   CLINICAL SCIENCE

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

(2020) Tao Zhang et al.   CURRENT BIOLOGY

SARS-CoV2: should inhibitors of the renin–angiotensin system be withdrawn in patients with COVID-19?

(2020) Gabriela M Kuster et al.   EUROPEAN HEART JOURNAL

Genotyping coronavirus SARS-CoV-2: methods and implications

(2020) Changchuan Yin   GENOMICS

Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

(2020) Jacques Fantini et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

COVID-19 spike-host cell receptor GRP78 binding site prediction

(2020) Ibrahim M. Ibrahim et al.   JOURNAL OF INFECTION

Distinct Viral Clades of SARS‐CoV‐2: Implications for Modeling of Viral Spread

(2020) Adam Brufsky   JOURNAL OF MEDICAL VIROLOGY

Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop

(2020) Javier A. Jaimes et al.   JOURNAL OF MOLECULAR BIOLOGY

Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity? Insights from All-Atoms Simulations

(2020) Angelo Spinello et al.   Journal of Physical Chemistry Letters

Comparing the Binding Interactions in the Receptor Binding Domains of SARS-CoV-2 and SARS-CoV

(2020) Muhamed Amin et al.   Journal of Physical Chemistry Letters

Genomic Analysis and Comparative Multiple Sequence of SARS-CoV2

(2020) Tai-Jay Chang et al.   Journal of the Chinese Medical Association

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

(2020) Meng Yuan et al.   SCIENCE

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics

(2020) Kuldeep Dhama et al.   Human Vaccines & Immunotherapeutics

Focus on Receptors for Coronaviruses with Special Reference to Angiotensin-converting Enzyme 2 as a Potential Drug Target - A Perspective

(2020) Thea Magrone et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development

(2020) Eun Kim et al.   EBioMedicine

Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19

(2020) Jiansheng Huang et al.   Journal of Clinical Medicine

COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles’ heel conserved region to minimize probability of escape mutations and drug resistance

(2020) B. Robson   COMPUTERS IN BIOLOGY AND MEDICINE

Tackling SARS-CoV-2: proposed targets and repurposed drugs

(2020) Siddhi Joshi et al.   Future Medicinal Chemistry

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

(2020) Hong-Long Ji et al.   PHYSIOLOGICAL REVIEWS

Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions

(2020) Yingjie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary relationships and sequence‐structure determinants in human SARS coronavirus‐2 spike proteins for host receptor recognition

(2020) Lalitha Guruprasad   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

(2020) Muhammad Adnan Shereen et al.   Journal of Advanced Research

Identification and characterization of a human coronavirus 229E nonstructural protein 8-associated RNA 3′-terminal adenylyltransferase activity

(2019) Jana Tvarogová et al.   JOURNAL OF VIROLOGY

The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases

(2019) Gonzalo Izaguirre   Viruses-Basel

X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket

(2018) Sven O. Dahms et al.   BIOCHEMISTRY

How large B-factors can be in protein crystal structures

(2018) Oliviero Carugo   BMC BIOINFORMATICS

Combining Stochastic Deformation/Relaxation and Intermolecular Contacts Analysis for Extracting Pharmacophores from Ligand–Receptor Complexes

(2018) Ma’mon M. Hatmal et al.   Journal of Chemical Information and Modeling

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond

(2015) Guangwen Lu et al.   TRENDS IN MICROBIOLOGY

Continuous and Discontinuous RNA Synthesis in Coronaviruses

(2015) Isabel Sola et al.   Annual Review of Virology

Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer

(2014) Xiongwei Deng et al.   BIOMATERIALS

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

(2014) Jean Kaoru Millet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein

(2014) Shuai Xia et al.   VIRUS RESEARCH

High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome

(2013) Sergey A. Shiryaev et al.   PLoS One

Regulation of Coronaviral Poly(A) Tail Length during Infection

(2013) Hung-Yi Wu et al.   PLoS One

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Computational prediction of furin cleavage sites by a hybrid method and understanding mechanism underlying diseases

(2012) Sun Tian et al.   Scientific Reports

Source of High Pathogenicity of an Avian Influenza Virus H5N1: Why H5 Is Better Cleaved by Furin

(2008) Panita Decha et al.   BIOPHYSICAL JOURNAL