Metallic Engineered Nanomaterials and Ocular Toxicity: A Current Perspective

Engineered Nanomaterials: The Challenges and Opportunities for Nanomedicines

(2021) Fahad Albalawi et al.   International Journal of Nanomedicine

Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation

(2021) Yen-Ju Chan et al.   Particle and Fibre Toxicology

Ocular Formulation Based on Palmitoylethanolamide-Loaded Nanostructured Lipid Carriers: Technological and Pharmacological Profile

(2020) Carmelo Puglia et al.   Nanomaterials

Association of the Somatostatin Analog Octreotide With Magnetic Nanoparticles for Intraocular Delivery: A Possible Approach for the Treatment of Diabetic Retinopathy

(2020) Rosario Amato et al.   Frontiers in Bioengineering and Biotechnology

Zinc oxide nanoparticles induce human tenon fibroblast apoptosis through reactive oxygen species and caspase signaling pathway

(2020) Ling Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Silver Nanoparticle-Induced Apoptosis in ARPE-19 Cells Is Inhibited by Toxoplasma gondii Pre-Infection Through Suppression of NOX4-Dependent ROS Generation

(2020) Juan-Hua Quan et al.   International Journal of Nanomedicine

Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective

(2020) Valeria De Matteis et al.   Cells

Nanoparticulate Drug Delivery to the Retina

(2020) Qingqing Li et al.   MOLECULAR PHARMACEUTICS

Nanoscale Drug Delivery Systems for Glaucoma: Experimental and In Silico Advances

(2020) Smriti Sharma et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery: Evaluation of the surface properties and effect on their distribution

(2020) P.S. Apaolaza et al.   EXPERIMENTAL EYE RESEARCH

Exposure and possible risks of engineered nanomaterials in the environment – current knowledge and directions for the future

(2020) Henning Wigger et al.   REVIEWS OF GEOPHYSICS

Emerging Trends in Nanomedicine for Improving Ocular Drug Delivery: Light-Responsive Nanoparticles, Mesoporous Silica Nanoparticles, and Contact Lenses

(2020) Flávia S. C. Rodrigues et al.   ACS Biomaterials-Science & Engineering

Toward understanding the purely geometric effects of silver nanoparticles on potential application as ocular therapeutics via treatment of bacterial keratitis

(2020) Duc Dung Nguyen et al.   Materials Science & Engineering C-Materials for Biological Applications

Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk

(2019) Ajaz A. Bhat et al.   Frontiers in Physiology

Structural dynamics of tight junctions modulate the properties of the epithelial barrier

(2019) Aapo Tervonen et al.   PLoS One

Zinc oxide nanoparticles ameliorate collagen lattice contraction in human tenon fibroblasts

(2019) Xuewei Yin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease

(2019) Xin Cong et al.   CELLULAR SIGNALLING

MiRNA-155-5p Reduces Corneal Epithelial Permeability by Remodeling Epithelial Tight Junctions during Corneal Wound Healing

(2019) Feng Wang et al.   CURRENT EYE RESEARCH

Preparation, Characterization, and Evaluation of Zinc Oxide Nanoparticles Suspension as an Antimicrobial Media for Daily Use Soft Contact Lenses

(2019) Maryam Shayani Rad et al.   CURRENT EYE RESEARCH

Cerium oxide nanoparticles protects against acrylamide induced toxicity in HepG2 cells through modulation of oxidative stress

(2018) Aala Azari et al.   DRUG AND CHEMICAL TOXICOLOGY

Development of copolymeric nanoparticles of hypocrellin B: Enhanced phototoxic effect and ocular distribution

(2018) Venkateshwaran Krishnaswami et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Phenotypic characterization of the SIRC (Statens Seruminstitut Rabbit Cornea) cell line reveals a mixed epithelial and fibroblastic nature

(2018) Melania Olivieri et al.   EXPERIMENTAL EYE RESEARCH

Silver nanoparticles: Electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review

(2018) Lucía Z. Flores-López et al.   JOURNAL OF APPLIED TOXICOLOGY

Development of facile drug delivery platform of ranibizumab fabricated PLGA-PEGylated magnetic nanoparticles for age-related macular degeneration therapy

(2018) Jian Yan et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Gold nanoparticles in ophthalmology

(2018) Florence Masse et al.   MEDICINAL RESEARCH REVIEWS

The inflammatory response to silver and titanium dioxide nanoparticles in the central nervous system

(2018) Tianshu Wu et al.   Nanomedicine

Real-time imaging of VCAM-1 mRNA in TNF- α activated retinal microvascular endothelial cells using antisense hairpin-DNA functionalized gold nanoparticles

(2018) MD Imam Uddin et al.   Nanomedicine-Nanotechnology Biology and Medicine

Surface Modifications of Nanoparticles for Stability in Biological Fluids

(2018) Luca Guerrini et al.   Materials

Zinc oxide nanoparticles induce murine photoreceptor cell death via mitochondria-related signaling pathway

(2018) Ling Wang et al.   Artificial Cells Nanomedicine and Biotechnology

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

(2018) Marion Dubald et al.   Pharmaceutics

Ocular Drug Delivery Barriers—Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases

(2018) Rinda Bachu et al.   Pharmaceutics

Water extract of indoor dust induces tight junction disruption in normal human corneal epithelial cells

(2018) Ping Xiang et al.   ENVIRONMENTAL POLLUTION

Risks, Release and Concentrations of Engineered Nanomaterial in the Environment

(2018) Bernd Giese et al.   Scientific Reports

Improving Stem Cell Delivery to the Trabecular Meshwork Using Magnetic Nanoparticles

(2018) E. J. Snider et al.   Scientific Reports

Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound-on-a-Chip Model

(2018) Sahar Biglari et al.   Advanced Healthcare Materials

Wound-on-a-chip: High-throughput 3D wound healing assay with a novel SU-8 mesh chip

(2018) Yachao Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Potential of CeCl 3 @mSiO 2 nanoparticles in alleviating diabetic cataract development and progression

(2017) Jin Yang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Intraocular application of gold nanodisks optically tuned for optical coherence tomography: inhibitory effect on retinal neovascularization without unbearable toxicity

(2017) Hyun Beom Song et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nano-ophthalmology: Applications and considerations

(2017) Mohammad Amin Kamaleddin   Nanomedicine-Nanotechnology Biology and Medicine

A review of reproductive and developmental toxicity of silver nanoparticles in laboratory animals

(2017) Makoto Ema et al.   REPRODUCTIVE TOXICOLOGY

Silver nanoparticles: Significance of physicochemical properties and assay interference on the interpretation of in vitro cytotoxicity studies

(2017) Kausar B. Riaz Ahmed et al.   TOXICOLOGY IN VITRO

Nanotechnology-based strategies for treatment of ocular disease

(2017) Yuhua Weng et al.   Acta Pharmaceutica Sinica B

Magnetic nanoparticles: a strategy to target the choroidal layer in the posterior segment of the eye

(2017) Martina Giannaccini et al.   Scientific Reports

Nanoparticle cross-linked collagen shields for sustained delivery of pilocarpine hydrochloride

(2016) Yosra Agban et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Magnetic Nanoparticles as a Potential Vehicle for Corneal Endothelium Repair

(2016) Lauren E. Cornell et al.   MILITARY MEDICINE

Prolonged Ocular Retention of Mucoadhesive Nanoparticle Eye Drop Formulation Enables Treatment of Eye Diseases Using Significantly Reduced Dosage

(2016) Shengyan Liu et al.   MOLECULAR PHARMACEUTICS

Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine

(2016) E. I. Alarcon et al.   Nanoscale

Safety and toxicity of nanomaterials for ocular drug delivery applications

(2016) Neelesh K. Mehra et al.   Nanotoxicology

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effect of Titanium Dioxide Nanoparticle Exposure on the Ocular Surface: An Animal Study

(2016) Youngsub Eom et al.   Ocular Surface

Tight junctions in pulmonary epithelia during lung inflammation

(2016) Oliver H. Wittekindt   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Steric stabilization of nanoparticles with grafted low molecular weight ligands in highly concentrated brines including divalent ions

(2016) Andrew J. Worthen et al.   Soft Matter

Biocompatibility of gold nanoparticles in retinal pigment epithelial cell line

(2016) Bedia Begüm Karakoçak et al.   TOXICOLOGY IN VITRO

Establishment of a novel in vitro model of stratified epithelial wound healing with barrier function

(2016) Miguel Gonzalez-Andrades et al.   Scientific Reports

Pure and multi metal oxide nanoparticles: synthesis, antibacterial and cytotoxic properties

(2016) Slavica Stankic et al.   JOURNAL OF NANOBIOTECHNOLOGY

A novel method for measuring zeta potentials of solid–liquid interfaces

(2015) Yongxin Song et al.   ANALYTICA CHIMICA ACTA

Zinc oxide nanoparticles inhibit murine photoreceptor-derived cell proliferation and migrationviareducing TGF-β and MMP-9 expressionin vitro

(2015) Da Dong Guo et al.   CELL PROLIFERATION

Nanoparticle colloidal stability in cell culture media and impact on cellular interactions

(2015) Thomas L. Moore et al.   CHEMICAL SOCIETY REVIEWS

A comprehensive review on synthesis methods for transition-metal oxide nanostructures

(2015) Ting Guo et al.   CRYSTENGCOMM

Characteristics of Reconstituted Tight Junctions After Corneal Epithelial Wounds and Ultrastructure Alterations of Corneas in Type 2 Diabetic Rats

(2015) Chenchen Huang et al.   CURRENT EYE RESEARCH

Toxicity of 11 Metal Oxide Nanoparticles to Three Mammalian Cell Types In V.itro

(2015) Angela Ivask et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Toxicological effects of silver nanoparticles

(2015) Jacob Joe Antony et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Efficacy and vitreous levels of topical NSAIDs

(2015) Francesco Semeraro et al.   Expert Opinion on Drug Delivery

Silver nanoparticles: Their potential toxic effects after oral exposure and underlying mechanisms – A review

(2015) Sylvie Gaillet et al.   FOOD AND CHEMICAL TOXICOLOGY

Cytotoxic effect of ZnS nanoparticles on primary mouse retinal pigment epithelial cells

(2015) Karthikeyan Bose et al.   Artificial Cells Nanomedicine and Biotechnology

Cerium Oxide Nanoparticles Reduce Microglial Activation and Neurodegenerative Events in Light Damaged Retina

(2015) Lavinia Fiorani et al.   PLoS One

Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems

(2014) Qingxin Mu et al.   CHEMICAL REVIEWS

Toxicity of Nanoparticles

(2014) Maria Zoroddu et al.   CURRENT MEDICINAL CHEMISTRY

Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)

(2014) Martina Giannaccini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Engineered Nanomaterials: Knowledge Gaps in Fate, Exposure, Toxicity, and Future Directions

(2014) Arun Kumar et al.   Journal of Nanomaterials

Assessing the impact of engineered nanoparticles on wound healing using a novel in vitro bioassay

(2014) Enhua H Zhou et al.   Nanomedicine

Anti-angiogenic effect of bare titanium dioxide nanoparticles on pathologic neovascularization without unbearable toxicity

(2014) Dong Hyun Jo et al.   Nanomedicine-Nanotechnology Biology and Medicine

Short versus long silver nanowires: a comparison of in vivo pulmonary effects post instillation

(2014) Rona M Silva et al.   Particle and Fibre Toxicology

UVB Irradiation Enhances TiO2Nanoparticle-induced Disruption of Calcium Homeostasis in Human Lens Epithelial Cells

(2014) Qiuxin Wu et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Silver and Gold Nanoparticles Exposure to In Vitro Cultured Retina – Studies on Nanoparticle Internalization, Apoptosis, Oxidative Stress, Glial- and Microglial Activity

(2014) Erika Söderstjerna et al.   PLoS One

Silica-based cerium (III) chloride nanoparticles prevent the fructose-induced glycation of α-crystallin and H2O2-induced oxidative stress in human lens epithelial cells

(2013) Jin Yang et al.   ARCHIVES OF PHARMACAL RESEARCH

Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review

(2013) Olesja Bondarenko et al.   ARCHIVES OF TOXICOLOGY

Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity

(2013) Vijay Krishna Raghunathan et al.   BIOMATERIALS

Nanoceria inhibit expression of genes associated with inflammation and angiogenesis in the retina of Vldlr null mice

(2013) Svetlana V. Kyosseva et al.   EXPERIMENTAL EYE RESEARCH

Dietary exposure to silver nanoparticles in Sprague–Dawley rats: Effects on oxidative stress and inflammation

(2013) R. Ebabe Elle et al.   FOOD AND CHEMICAL TOXICOLOGY

Topical delivery of ocular therapeutics: carrier systems and physical methods

(2013) Joel G. Souza et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Functions of corneal endothelial cells do not change after uptake of superparamagnetic iron oxide nanoparticles

(2013) YAN-LONG BI et al.   Molecular Medicine Reports

Mechanisms of toxic action of Ag, ZnO and CuO nanoparticles to selected ecotoxicological test organisms and mammalian cellsin vitro: A comparative review

(2013) Angela Ivask et al.   Nanotoxicology

BMP7 Gene Transfer via Gold Nanoparticles into Stroma Inhibits Corneal Fibrosis In Vivo

(2013) Ashish Tandon et al.   PLoS One

Oral toxicity of silver ions, silver nanoparticles and colloidal silver – A review

(2013) Niels Hadrup et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The economic burden of visual impairment and blindness: a systematic review

(2013) Juliane Köberlein et al.   BMJ Open

Nanomaterials for Ocular Drug Delivery

(2012) Shengyan Liu et al.   MACROMOLECULAR BIOSCIENCE

Genotoxicity, acute oral and dermal toxicity, eye and dermal irritation and corrosion and skin sensitisation evaluation of silver nanoparticles

(2012) Jin Sik Kim et al.   Nanotoxicology

A contemporary concept of the blood–aqueous barrier

(2012) Thomas F. Freddo   PROGRESS IN RETINAL AND EYE RESEARCH

Aldose Reductase, Oxidative Stress, and Diabetic Mellitus

(2012) Wai Ho Tang et al.   Frontiers in Pharmacology

Breakdown of the Blood-Ocular Barrier as a Strategy for the Systemic Use of Nanosystems

(2012) Marcelo L. Occhiutto et al.   Pharmaceutics

Protein−Nanoparticle Interactions: Opportunities and Challenges

(2011) Morteza Mahmoudi et al.   CHEMICAL REVIEWS

Nanotechnology and Nanotoxicology in Retinopathy

(2011) Dong Hyun Jo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polyethylenimine-conjugated gold nanoparticles: Gene transfer potential and low toxicity in the cornea

(2011) Ajay Sharma et al.   Nanomedicine-Nanotechnology Biology and Medicine

The effect of high concentration and exposure duration of nanoceria on human lens epithelial cells

(2011) Barbara K. Pierscionek et al.   Nanomedicine-Nanotechnology Biology and Medicine

Current sunscreen controversies: a critical review

(2011) Mark E. Burnett et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

Evaluation of Magnetic Micro- and Nanoparticle Toxicity to Ocular Tissues

(2011) Hemalatha B. Raju et al.   PLoS One

Toxicology of engineered nanomaterials: Focus on biocompatibility, biodistribution and biodegradation

(2010) Andrea Kunzmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The inhibition of retinal neovascularization by gold nanoparticles via suppression of VEGFR-2 activation

(2010) Jin Hyoung Kim et al.   BIOMATERIALS

Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies

(2010) Nikolai Khlebtsov et al.   CHEMICAL SOCIETY REVIEWS

Detection of TiO2 nanoparticles in cells by flow cytometry

(2010) R. M. Zucker et al.   CYTOMETRY PART A

Flower-shaped gold nanoparticles: synthesis, characterization and their application as SERS-active tags inside living cells

(2010) Sanda Boca et al.   NANOTECHNOLOGY

Dynamics and functions of tight junctions

(2010) Emily Steed et al.   TRENDS IN CELL BIOLOGY

Stability of metal oxide nanoparticles in aqueous solutions

(2010) Chih-ping Tso et al.   WATER SCIENCE AND TECHNOLOGY

Effects of nanomaterial physicochemical properties on in vivo toxicity

(2009) Kristin L. Aillon et al.   ADVANCED DRUG DELIVERY REVIEWS

Silver nanoparticles inhibit VEGF induced cell proliferation and migration in bovine retinal endothelial cells

(2009) Kalimuthu Kalishwaralal et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Subretinal delivery of immunoglobulin G with gold nanoparticles in the rabbit eye

(2009) Atsushi Hayashi et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Nanoceria have no genotoxic effect on human lens epithelial cells

(2009) Barbara K Pierscionek et al.   NANOTECHNOLOGY

Intravenously administered gold nanoparticles pass through the blood–retinal barrier depending on the particle size, and induce no retinal toxicity

(2009) Jeong Hun Kim et al.   NANOTECHNOLOGY

What does the cell see?

(2009) Iseult Lynch et al.   Nature Nanotechnology

ABSENCE OF HISTOLOGIC RETINAL TOXICITY OF INTRAVITREAL NANOGOLD IN A RABBIT MODEL

(2009) SOPHIE J. BAKRI et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties

(2008) Tian Xia et al.   ACS Nano

Nanotechnology in ocular drug delivery

(2008) S SAHOO et al.   DRUG DISCOVERY TODAY

Size Dependent and Reactive Oxygen Species Related Nanosilver Toxicity to Nitrifying Bacteria

(2008) Okkyoung Choi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells

(2008) Maqusood Ahamed et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY