The Structural Biology of Septins and Their Filaments: An Update

A septin GTPase scaffold of dynein–dynactin motors triggers retrograde lysosome transport

(2021) Ilona A. Kesisova et al.   JOURNAL OF CELL BIOLOGY

Orientational Ambiguity in Septin Coiled Coils and its Structural Basis

(2021) Diego A. Leonardo et al.   JOURNAL OF MOLECULAR BIOLOGY

A lysine–cysteine redox switch with an NOS bridge regulates enzyme function

(2021) Marie Wensien et al.   NATURE

Membrane binding controls ordered self-assembly of animal septins

(2021) Agata Szuba et al.   eLife

Insights into animal septins using recombinant human septin octamers with distinct SEPT9 isoforms

(2021) Francois Iv et al.   JOURNAL OF CELL SCIENCE

An atomic model for the human septin hexamer by cryo-EM

(2021) Deborah C. Mendonça et al.   JOURNAL OF MOLECULAR BIOLOGY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Proteomic profiling of the oncogenic septin 9 reveals isoform‐specific interactions in breast cancer cells

(2021) Louis Devlin et al.   PROTEOMICS

Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling

(2021) Benjamin L. Woods et al.   MOLECULAR BIOLOGY OF THE CELL

Guanidine hydrochloride reactivates an ancient septin hetero-oligomer assembly pathway in budding yeast

(2020) Courtney R Johnson et al.   eLife

The history of septin biology and bacterial infection

(2020) Stevens Robertin et al.   CELLULAR MICROBIOLOGY

The LKB1-like Kinase Elm1 Controls Septin Hourglass Assembly and Stability by Regulating Filament Pairing

(2020) Joseph Marquardt et al.   CURRENT BIOLOGY

A complete compendium of crystal structures for the human SEPT3 subgroup reveals functional plasticity at a specific septin interface

(2020) Danielle Karoline Silva do Vale Castro et al.   IUCrJ

Synergistic role of nucleotides and lipids for the self-assembly of Shs1 septin oligomers

(2020) Cyntia Taveneau et al.   BIOCHEMICAL JOURNAL

Molecular Recognition at Septin Interfaces: The Switches Hold the Key

(2020) Higor Vinícius Dias Rosa et al.   JOURNAL OF MOLECULAR BIOLOGY

Masters of asymmetry – lessons and perspectives from 50 years of septins

(2020) Elias T. Spiliotis et al.   MOLECULAR BIOLOGY OF THE CELL

The hierarchical assembly of septins revealed by high-speed AFM

(2020) Fang Jiao et al.   Nature Communications

Revised subunit order of mammalian septin complexes explains their in-vitro polymerization properties

(2020) Forooz Soroor et al.   MOLECULAR BIOLOGY OF THE CELL

An amphipathic helix enables septins to sense micrometer-scale membrane curvature

(2019) Kevin S. Cannon et al.   JOURNAL OF CELL BIOLOGY

Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors

(2019) Hongda Li et al.   NEURON

A blueprint of septin expression in human tissues

(2019) Luíza Zuvanov et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Revisiting SEPT7 and the slippage of β-strands in the septin family

(2019) Gabriel Brognara et al.   JOURNAL OF STRUCTURAL BIOLOGY

Correct partner makes the difference: Septin G-interface plays a critical role in amyloid formation

(2019) Patricia S. Kumagai et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Septin functions during neuro-development, a yeast perspective

(2019) Julien Falk et al.   CURRENT OPINION IN NEUROBIOLOGY

A revised order of subunits in mammalian septin complexes

(2019) Deborah C. Mendonça et al.   Cytoskeleton

Septin 2/6/7 complexes tune microtubule plus-end growth and EB1 binding in a concentration- and filament-dependent manner

(2019) Konstantinos Nakos et al.   MOLECULAR BIOLOGY OF THE CELL

Septins - active GTPases or just GTP-binding proteins?

(2018) Megha Abbey et al.   Cytoskeleton

Architecture, remodeling, and functions of the septin cytoskeleton

(2018) Joseph Marquardt et al.   Cytoskeleton

Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin

(2018) Eva P. Karasmanis et al.   DEVELOPMENTAL CELL

Septin-based readout of PI(4,5)P2 incorporation into membranes of giant unilamellar vesicles

(2018) Alexandre Beber et al.   Cytoskeleton

Dissecting the nucleotide binding properties of the Septins from S. cerevisiae

(2018) Julian David Baur et al.   Cytoskeleton

Regulation of microtubule plus end dynamics by septin 9

(2018) Konstantinos Nakos et al.   Cytoskeleton

Septin Mutations and Phenotypes in S. cerevisiae

(2018) Alexander Mela et al.   Cytoskeleton

Crystallographic identification of spontaneous oxidation intermediates and products of protein sulfhydryl groups

(2018) Jimin Wang   PROTEIN SCIENCE

Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction

(2018) Davide Tamborrini et al.   Nature Communications

Filaments and fingers: Novel structural aspects of the single septin from Chlamydomonas reinhardtii

(2017) Andressa P. A. Pinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation of human septins is critical for septin filament bundling and cytokinesis

(2017) David Ribet et al.   JOURNAL OF CELL BIOLOGY

Coiled Coils – A Model System for the 21st Century

(2017) Andrei N. Lupas et al.   TRENDS IN BIOCHEMICAL SCIENCES

The step-wise pathway of septin hetero-octamer assembly in budding yeast

(2017) Andrew Weems et al.   eLife

Septin 9_i2 is downregulated in tumors, impairs cancer cell migration and alters subnuclear actin filaments

(2017) P. Verdier-Pinard et al.   Scientific Reports

Biophysical dissection of schistosome septins: Insights into oligomerization and membrane binding

(2016) Ana Eliza Zeraik et al.   BIOCHIMIE

Heterotypic Coiled-Coil Formation is Essential for the Correct Assembly of the Septin Heterofilament

(2016) Fernanda A. Sala et al.   BIOPHYSICAL JOURNAL

Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton

(2016) Andrew A. Bridges et al.   JOURNAL OF CELL BIOLOGY

Detection of protein–protein interactions at the septin collar in Saccharomyces cerevisiae using a tripartite split-GFP system

(2016) Gregory C. Finnigan et al.   MOLECULAR BIOLOGY OF THE CELL

Septins guide microtubule protrusions induced by actin-depolymerizing toxins likeClostridium difficiletransferase (CDT)

(2016) Thilo Nölke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On methylene-bridged cysteine and lysine residues in proteins

(2016) Milosz Ruszkowski et al.   PROTEIN SCIENCE

GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis

(2016) Megha Abbey et al.   Scientific Reports

Comprehensive Genetic Analysis of Paralogous Terminal Septin Subunits Shs1 and Cdc11 in Saccharomyces cerevisiae

(2015) Gregory C. Finnigan et al.   GENETICS

Septin Dynamics Are Essential for Exocytosis

(2015) Elmira Tokhtaeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins

(2015) Y.-C. Kuo et al.   JOURNAL OF CELL SCIENCE

Septin 9 Exhibits Polymorphic Binding to F-Actin and Inhibits Myosin and Cofilin Activity

(2015) Clayton Smith et al.   JOURNAL OF MOLECULAR BIOLOGY

Comprehensive Genetic Analysis of Paralogous Terminal Septin Subunits Shs1 and Cdc11 in Saccharomyces cerevisiae

(2015) Gregory C. Finnigan et al.   GENETICS

Crystal Structure of aSchistosoma mansoniSeptin Reveals the Phenomenon of Strand Slippage in Septins Dependent on the Nature of the Bound Nucleotide

(2014) Ana E. Zeraik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR

(2014) K. Diesenberg et al.   JOURNAL OF CELL SCIENCE

Cell type–specific expression of SEPT3-homology subgroup members controls the subunit number of heteromeric septin complexes

(2014) Mikael E. Sellin et al.   MOLECULAR BIOLOGY OF THE CELL

Septins promote F-actin ring formation by crosslinking actin filaments into curved bundles

(2014) Manos Mavrakis et al.   NATURE CELL BIOLOGY

Distinct Septin Heteropolymers Co-Exist during Multicellular Development in the Filamentous Fungus Aspergillus nidulans

(2014) Yainitza Hernández-Rodríguez et al.   PLoS One

A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks

(2014) Helge Ewers et al.   PLoS One

Septin assemblies form by diffusion-driven annealing on membranes

(2014) Andrew A. Bridges et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Septin 9 amplification and isoform-specific expression in peritumoral and tumor breast tissue

(2013) Diana Connolly et al.   BIOLOGICAL CHEMISTRY

Human septin isoforms and the GDP-GTP cycle

(2013) Eldar Zent et al.   BIOLOGICAL CHEMISTRY

Novel septin 9 repeat motifs altered in neuralgic amyotrophy bind and bundle microtubules

(2013) Xiaobo Bai et al.   JOURNAL OF CELL BIOLOGY

Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation

(2013) Natsumi Ageta-Ishihara et al.   Nature Communications

The structure and properties of septin 3: a possible missing link in septin filament formation

(2012) Joci N. A. Macedo et al.   BIOCHEMICAL JOURNAL

Septin-Driven Coordination of Actin and Microtubule Remodeling Regulates the Collateral Branching of Axons

(2012) Jianli Hu et al.   CURRENT BIOLOGY

Posttranslational modifications and assembly of septin heteropolymers and higher-order structures

(2012) Yainitza Hernández-Rodríguez et al.   CURRENT OPINION IN MICROBIOLOGY

Septin Phosphorylation and Coiled-Coil Domains Function in Cell and Septin Ring Morphology in the Filamentous Fungus Ashbya gossypii

(2012) Rebecca A. Meseroll et al.   EUKARYOTIC CELL

Uncovering Principles That Control Septin-Septin Interactions

(2012) Moshe S. Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome

(2012) Houjiang Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Septins: the fourth component of the cytoskeleton

(2012) Serge Mostowy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB

(2012) P. Van Damme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self assembly of human septin 2 into amyloid filaments

(2011) Julio Cesar Pissuti Damalio et al.   BIOCHIMIE

Septin genomics: a road less travelled

(2011) S.E. Hilary Russell et al.   BIOLOGICAL CHEMISTRY

Structural and biochemical properties of Sept7, a unique septin required for filament formation

(2011) Eldar Zent et al.   BIOLOGICAL CHEMISTRY

Septin9 is involved in septin filament formation and cellular stability

(2011) Annette Füchtbauer et al.   BIOLOGICAL CHEMISTRY

New insights into the phylogenetic distribution and evolutionary origins of the septins

(2011) Ryuichi Nishihama et al.   BIOLOGICAL CHEMISTRY

Characterization of human septin interactions

(2011) Kirstin Sandrock et al.   BIOLOGICAL CHEMISTRY

Septin C-Terminal Domain Interactions: Implications for Filament Stability and Assembly

(2011) Ivo Almeida Marques et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Septin Filament Formation Is Essential in Budding Yeast

(2011) Michael A. McMurray et al.   DEVELOPMENTAL CELL

Promiscuous interactions of human septins: The GTP binding domain of SEPT7 forms filaments within the crystal

(2011) Vitor Hugo Balasco Serrão et al.   FEBS LETTERS

Subunit-dependent modulation of septin assembly: Budding yeast septin Shs1 promotes ring and gauze formation

(2011) Galo Garcia et al.   JOURNAL OF CELL BIOLOGY

SEPT9 occupies the terminal positions in septin octamers and mediates polymerization-dependent functions in abscission

(2011) Moshe S. Kim et al.   JOURNAL OF CELL BIOLOGY

Deciphering the rules governing assembly order of mammalian septin complexes

(2011) Mikael E. Sellin et al.   MOLECULAR BIOLOGY OF THE CELL

Spatial Guidance of Cell Asymmetry: Septin GTPases Show the Way

(2011) Elias T. Spiliotis et al.   TRAFFIC

Entrapment of Intracytosolic Bacteria by Septin Cage-like Structures

(2010) Serge Mostowy et al.   Cell Host & Microbe

Conquering the complex world of human septins: implications for health and disease

(2010) EA Peterson et al.   CLINICAL GENETICS

Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission

(2010) Mathew P. Estey et al.   JOURNAL OF CELL BIOLOGY

Phosphatidylinositol-4,5-bisphosphate Promotes Budding Yeast Septin Filament Assembly and Organization

(2010) Aurélie Bertin et al.   JOURNAL OF MOLECULAR BIOLOGY

A Draft of the Human Septin Interactome

(2010) Marcel Nakahira et al.   PLoS One

A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution

(2010) Q. Hu et al.   SCIENCE

Septin-Mediated Uniform Bracing of Phospholipid Membranes

(2009) Yohko Tanaka-Takiguchi et al.   CURRENT BIOLOGY

It takes two to tango: regulation of G proteins by dimerization

(2009) Raphael Gasper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GTP-induced conformational changes in septins and implications for function

(2009) M. Sirajuddin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulation of SEPT9_v1 stabilizes c-Jun-N-Terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells

(2008) Maria E. Gonzalez et al.   CELLULAR SIGNALLING

Targeting Metastable Coiled-Coil Domains by Computational Design

(2008) Patrick Barth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The septin family of GTPases: architecture and dynamics

(2008) Christine S. Weirich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Saccharomyces cerevisiae septins: Supramolecular organization of heterooligomers and the mechanism of filament assembly

(2008) A. Bertin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The GTPase Cycle of the Chloroplast Import Receptors Toc33/Toc34: Implications from Monomeric and Dimeric Structures

(2008) Patrick Koenig et al.   STRUCTURE