PI3Kγ kinase activity is required for optimal T-cell activation and differentiation

Selective Regulation of CD8 Effector T Cell Migration by the p110  Isoform of Phosphatidylinositol 3-Kinase

(2014) A. L. Martin et al.   JOURNAL OF IMMUNOLOGY

ICOS Ligation Recruits the p50  PI3K Regulatory Subunit to the Immunological Synapse

(2014) C. Fos et al.   JOURNAL OF IMMUNOLOGY

Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels

(2012) Stephanie J. Harris et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibition of T-cell activation by PIK3IP1

(2012) Marie C. DeFrances et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Blockade of Phosphatidylinositol 3-Kinase (PI3K)δ or PI3Kγ Reduces IL-17 and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis

(2012) Anne Roller et al.   JOURNAL OF IMMUNOLOGY

A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation

(2012) Giovanna Bergamini et al.   Nature Chemical Biology

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

PI3Kγ deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome

(2011) Luciana Berod et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Akt Fine-tunes NF-κB-dependent Gene Expression during T Cell Activation

(2011) Jing Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+human memory T cells

(2011) Qi Wan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PI3K p110  regulates T-cell cytokine production during primary and secondary immune responses in mice and humans

(2010) D. R. Soond et al.   BLOOD

Loss of phosphoinositide 3-kinase γ decreases migration and activation of phagocytes but not T cell activation in antigen-induced arthritis

(2010) Michael Gruen et al.   BMC MUSCULOSKELETAL DISORDERS

The absence of functional PI3Kγ prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice

(2010) Willemijn A. van Dop et al.   IMMUNOLOGY LETTERS

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase γ–deficient mice

(2009) Masahide Takeda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of PI3Kδ and PI3Kγ in inflammatory arthritis and tissue localization of neutrophils

(2008) Tara M. Randis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting phosphoinositide 3-kinase—Moving towards therapy

(2007) Romina Marone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS